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THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS J Pharmacol Exp Ther 351:1–7, November 2014 Copyright ª 2014 by The American Society for Pharmacology and Experimental Therapeutics Attenuated Aortic Vasodilation and Sympathetic Prejunctional Facilitation in Epinephrine-Deficient Mice: Q:1 Selective Impairment of b2-Adrenoceptor Responses Mónica Moreira-Rodrigues, Ana L. Graça, Marlene Ferreira, Joana Afonso, Paula Serrão,Manuela Morato, Fátima Ferreirinha, Paulo Correia-de-Sá, Steven N. Ebert,and Daniel MouraLaboratory of General Physiology (M.M.-R.) and Laboratory of Pharmacology and Neurobiology (F.F., P.C.), Unit forMultidisciplinary Investigation in Biomedicine, Institute of Biomedical Sciences Abel Salazar, University of Porto; Department ofPharmacology and Therapeutics, Faculty of Medicine, University of Porto (A.L.G., M.F., J.A., P.S., D.M.); Neuropharmacology,Institute of Molecular and Cellular Biology, University of Porto (M.M., D.M.); Center for Drug Discovery and Innovative Medicines,University of Porto, Porto, Portugal (M.M.-R., A.L.G., M.F., J.A., P.S., M.M., F.F., P.C., D.M.); Laboratory of Pharmacology,Department of Drug Sciences, Faculty of Pharmacy, University of Porto and Rede de Quimic e Tecnologia (REQUIMTE), Porto,Portugal (M.M.); and Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida (S.N.E.).Received June 4, 2014; accepted August 25, 2014
Treatment of Bacterial Overgrowth in Patients With Irritable Bowel Syndrome Background: Rifaximin is an effective treatment of irritable bowel syndrome (IBS) with small intestinal bacterial overgrowth (SIBO), yet long-term management has not been well studied. Patients with functional bowel symptoms were characterized by lactulose breath test (LBT), and a comprehensive approach to long-term SIBO therapy was employed. Methods: On day 0, eligible patients completed a baseline symptom questionnaire and were offered rifaximin 1200 mg/d for 10 days followed by tegaserod 3 mg nightly (long-term) plus 1 month of zinc 220 mg/d and a bifidobacteria-based probiotic once daily. Two months later, patients were administered a follow-up questionnaire regarding symptoms at the time of completion of rifaximin therapy and their current symptoms. Results: 161 of 212 patients with an abnormal LBT met Rome II criteria for IBS. High-methane producers were more likely to have constipation. After completion of rifaximin treatment, ≥50% improvement from baseline was reported by 72% of patients for abdominal pain, 67% for flatulence, 62% for bloating, 58% for constipation, 56% for diarrhea, and 53% for fullness. Similar results were reported at 2 months. Global IBS symptoms at 2 months were reported by 60% of patients to be moderately or greatly improved. Moderately or greatly improved symptoms were more frequent among high-methane producers (83%) than high-hydrogen producers (56%) or high producers of both methane and hydrogen (44%). Conclusions: Rifaximin treatment followed by adjunctive therapy was associated with sustained improvement in patients with IBS and SIBO. High-methane producers experienced more frequent constipation and reported greater clinical response compared with high-hydrogen producers.
Berliner und Münchener Tierärztliche Wochenschrift 128, Heft 11/12 (2015), Seiten 43–50 Institut für Parasitologie der Tierärztlichen Hochschule Hannover1 Open Access Institut für Parasitologie der Veterinärmedizinischen Fakultät der Universität Leipzig2 Berl Münch Tierärztl Wochenschr 128, 43–50 (2015)DOI 10.2436/0005-9466-128-43
Current Learning in Palliative care Helping patients with symptoms other than pain 1: Constipation Introductory level Aim of this worksheet Produced by St. Oswald's Hospice To learn how to assess and manage constipation How to use this worksheet You can work through this worksheet by yourself, or with a tutor.
Sample Information • Raw commingled cow milk must be used. The sample spot is darker than or equal to the control spot. • Samples must be refrigerated and tested within three days of collection. • Thoroughly mix the sample before testing.• DO NOT use abnormal-looking milk. The sample spot is lighter than the control spot.
Impaired muscle metaboreflex-induced increases inventricular function in heart failure Donal S. O'Leary, Javier A. Sala-Mercado, Robert A. Augustyniak, Robert L.Hammond, Noreen F. Rossi and Eric J. AnsorgeAm J Physiol Heart Circ Physiol 287:H2612-H2618, 2004. First published 15 July 2004;doi:10.1152/ajpheart.00604.2004
A&A 460, 597–604 (2006) Transition region counterpart of a moving magnetic feature C.-H. Lin1,2,3, D. Banerjee4, E. O'Shea1, and J. G. Doyle1 1 Armagh Observatory, College Hill, Armagh BT61 9DG, North Ireland, UK e-mail: firstname.lastname@example.org 2 National Center for Theoretical Sciences, Physics division, National Tsing-Hua University, Hsinchu, Taiwan3 Astronomy Department, Yale University, New Haven, CT06511, USA4 Indian Institute of Astrophysics, Koramangala, Bangalore 560034, India
Multidisciplinary inquiry-based investigation learning using an ex ovo chicken culture platform: role of vitamin a on embryonic morphogenesis
I n q u I r y & Multidisciplinary Inquiry-Based Learning Using an Ex Ovo Chicken Culture Platform: Role of Vitamin A on Embryonic Morphogenesis PhiliP R. Buskohl, Russell A. Gould, susAn CuRRAn, shivAun d. ARCheR, JonAthAn t. ButCheR has been correlated with increased risk of congenital defects of
Newsletter 2008-12 der AG Medizinrecht im Deutschen AnwaltVerein Liebe Kolleginnen, liebe Kollegen, die Mitglieder Ihrer Arbeitsgemeinschaft wünschen Ihnen eine besinnliche Vorweihnachtszeit und ein ruhiges Fest im Kreise Ihrer Familie und Freunden. Ihre Rita Schulz-Hillenbrand Rechtsanwältin Fachanwältin für Medizinrecht Arzneimittel-, Medizinprodukte- und Apothekenrecht
W H AT W E K N O W Managing Medication for Adults with AD/HDAD/HD is recognized as a neurobiological disorder that often persists from childhood into adulthood, resulting in about 4-5% of adults having AD/HD.1-5 Medication, which is an integral part of the multimodal treatment of AD/HD in children, is the cornerstone of treatment for adults.6-8 Although there is a significant amount of research in children, there is much less controlled research data on medication therapy in adults.4,9 Regarding the use of medication in the treatment of AD/HD, it has been said that "pills do not substitute for skills."45 This means that medication alone is not sufficient to help a person improve his or her problems in areas such as organization, time management, prioritizing, and using cognitive aids. However, medication levels the neurobiologic playing field, and allows adults with AD/HD to learn and develop the skills they need to succeed.
About division of pharmaceuticals in course of blistering and it´s EVALUATION ACCORDING TO THE ORDINANCE ON THE OPERATION OF PHARMACIES DR. RER. NAT. THOMAS WELLENHOFER AND RA VEITH RÖSSGER TRANSLATED BY SEBASTIAN BECK IfpiV Zwieselstr. 15, 83395 Freilassing Are divided pharmaceuticals in nursing homes replaceable? Is it necessary to proof drugs durability in case of division?
Reference interval changes 2 Significance of ANCA 4 Type 1 diabetes 6 INSIDe Clinical Utility of Bone Turnover Markers 8 Ulysses Syndrome – is it the liver? 10 Test ordering standardisation 11 Order of Draw Quick Guide 12 HbA1cFor our patients and our population transport improvement, will enable us to Complement method change From the Executive Director meet future challenges and maintain
Hier finden Sie Fragen und Antworten aus dem Expertenforum "Haarausfall" zum Nachlesen. Ich leide an Alopecia areata und habe meine Kopfhaare und Teile von Augenbrauen und Wimpern verloren. Welche Chancen habe ich, wieder Haare zu bekommen? Gibt es noch andere Heilmethoden außer DCP? Bei einer geringen Ausprägung des kreisrunden Haarausfalls und noch kurzer Erkrankungsdauer kann die Einnahme von Zink hilfreich sein. An die Akutphase kann sich eine Reiztherapie mit Dithranol bzw. Cignolin anschließen, einem äußerlich anzuwendenden Arzneimittel, das sonst in der Behandlung der Schuppenflechte eingesetzt wird. Bei Ihnen handelt es sich jedoch um einen schweren Verlauf mit völligem Haarverlust. Die Wahrscheinlichkeit, ein Nachwachsen der Haare zu erreichen, sinkt mit dem Schweregrad (Ausbreitung und zeitlicher Verlauf) der Alopezie. Auch die Therapie mit der Chemikalie DCP führt nur in weniger als der Hälfte der Fälle zu einem Nachwachsen. Daher ist es bei schweren Formen der Alopecia areata meistens empfehlenswert, sich frühzeitig um eine optimale Zweithaarversorgung zu kümmern.
rofessor Sir Simon Wessely – R ight or Wrong? Margaret Williams 28th October 2013 [Plus UPDATE 21st April 2014 follows below] When a professional person – especially a doctor – has repeatedly been shown to be wrong in their professional judgment and, as a direct consequence, people have been harmed, that doctor should surely be held personally responsible and accountable: in such circumstances legitimate criticism should not be dismissed as an ad hominem (personal) attack.Following the award of the inaugural John Maddox Prize to psychiatrist Professor Sir Simon Wessely for his alleged "courage" in "standing up for science" and for promoting "sound science" about ME/CFS in the face of "hostility" in doing so, a letter published on 13th January 2013 by the Countess of Mar, Professor Malcolm Hooper and Dr William Weir in The Independent on Sunday was explicit that criticism of Wessely's hypothesis about ME/CFS is scientifically legitimate:"Scientific understanding always depends upon sound evidence….For scientific understanding to prevail, the extensive biomedical evidence-base of ME/CFS must now be recognised by all researchers in the field. The idea that ME/CFS is due to a dysfunctional psyche is a hypothesis without an evidence-base. The Maddox Prize was therefore awarded to the defender of an hypothesis with no evidence-base rather than to someone who was upholding true scientific inquiry. Personal attacks against Professor Sir Simon Wessely do not advance the cause, but it is scientifically legitimate to direct criticism at the hypothesis both he and Professor White (chief Principal Investigator of the MRC's PACE trial on ME/CFS) continue to espouse". It has been shown time and again that Professor Sir Simon's published assertions about disorders such as ME/CFS, fibromyalgia, Gulf War Syndrome, the Camelford drinking water poisoning, and interstitial cystitis are simply wrong. Merely stating so is likely to result in yet more claims by him of "harassment" and "attack" upon him but, in the words of Professor Martin Bland, one of the UK's leading medical statisticians, it is important that false information should not remain on the record to be quoted uncritically by others: "Potentially incorrect conclusions, based on faulty analysis, should not be allowed to remain in the literature to be cited uncritically by others" (Fatigue and psychological distress. BMJ: 19th February 2000:320:515-516). Wessely's "incorrect conclusions", however, remain in the literature to be cited uncritically by others and therefore may result in iatrogenic harm.ME/CFSFor over 25 years Wessely's dismissal and rejection of the biomedical evidence on ME has continued unabated, even though there is substantial evidence of on-going inflammation throughout the body; systems prominently affected are the central and autonomic nervous systems, the immune system and the cardiovascular, endocrine, gastro-intestinal and musculoskeletal systems.
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Vicaría de Evangelización © Arquidiócesis de Bogotá, 2013 PLAN DE EVANGELIZACIÓN Portada: Panorámica del Centro Internacional y los cerros en Bogotá Vicaría de Evangelización Arquidiócesis de Bogotá Archivo de la Arquidiócesis de Bogotá Juan Carlos Ramos Hendez Diseño, diagramación: Juan Carlos Ramos Hendez ISPA. Instituto San Pablo Apóstol © Todos los derechos reservados