Marys Medicine


Microsoft word - jill depledge pelvic joint pain during pregnancy.docx

This review formed part of Jill Depledge's MHSc thesis at AUT

Pelvic joint pain in pregnancy
The literature pertaining to pain in the symphysis pubis and sacroiliac joints during pregnancy is reviewed here. The signs and symptoms associated with symphysis pubis dysfunction are also discussed. Pelvic joint pain is a common complaint for pregnant women and as its name suggests encompasses pain in any or all of the pelvic joints. There is very little work focusing on symphysis pubis pain during pregnancy, given that it is a significant problem for many women. Most of the literature addresses "peripartum pain" (pain antenatally, during childbirth or postnatally) and considers the primary problem to be posterior pelvic joint pain with or without anterior (symphysis pubis) pain. A large number of different names have been used to describe joint pain in the pelvic region during the peripartum period, including symphysiolysis (Schwartz, Katz, & Lancet, 1985), symphysis pubis separation (Taylor & Sonson, 1986), symptomatic symphyseal separation (Kubitz & Goodlin, 1986), pelvic joint instability (Saugstad, 1991), posterior pelvic pain (Ostgaard et al., 1994), diastasis symphysis pubis (Scriven, Jones, & McKnight, 1995), peripartum pelvic pain (Mens, Vleeming, Stoeckart, Stam, & Snijders, 1996; Vleeming et al., 1997), and symphysis pubis dysfunction (Fry, 1999). Some of these acknowledge the involvement of all pelvic joints and others focus on the one which is most affected. The large variety in names probably suggests the diversity in symptoms experienced. It is difficult to determine the prevalence of pelvic joint pain during pregnancy, as there are so many variations in names and definitions and such a small volume of literature available on antenatal women. The reported prevalence rate of pelvic pain (all types) during pregnancy ranges between 48% and 56% (Mantle et al., 1981; Mens et al., 1997; Bjorklund et al., 1999), with the rate of severe dysfunction ranging from 15% to 22%. In terms of symphysis pubis dysfunction during pregnancy, the only reported rate was 1:300 (from one hospital) by Kubitz & Goodlin (1986). More recently MacLennan & MacLennan (1997) found that 31.7% of respondents in their retrospective survey of women with symptom-giving pelvic girdle relaxation of pregnancy had antenatal symphysis pubis pain. The majority of literature pertaining to problems with the symphysis pubis is in the form of case reports of symphysis pubis diastasis (from 1cm to 5.8cm) during childbirth. This is a rare event and does not appear to be related to antenatal symphysis pubis dysfunction (Schwartz et al., 1985; Taylor & Sonson, 1986; Lindsey, Leggon, Wright, & Nolasco, 1988; Dhar & Anderton, 1992; Musumeci & Villa, 1994; Kowalk, Perdue, Bourgeois, & Whitehill, 1996; Kharrazi, Rodgers, Kennedy, & Lhowe, 1997; Snow & Neubert, 1997). Another rare condition is symphysis pubis rupture following a traumatic event during pregnancy (Luger, Arbel, & Dekel, 1995). Fry (1999) defined the term symphysis pubis dysfunction as the inability of the symphysis pubis to effectively perform its role in pelvic stabilisation, thus altering pelvic biomechanics and impairing efficient weightbearing. The location of the symptoms may suggest that this is a problem of the symphysis pubis only, but as stated previously none of the pelvic joints can be considered in isolation. One theory for symptoms being felt only at this joint, despite the fact that there must be simultaneous involvement of the sacroiliac joints, has been suggested by Vleeming et al. (1992a) to be the result of an unbalanced relaxation (due to relaxin being at different levels) of the sacroiliac joints and the symphysis pubis. Fry (1999) and Sheppard (1997) have suggested that symphysis pubis dysfunction is generally underdiagnosed despite being a significant obstetric problem with consequences for the sufferer being underrated. Conversely Renckens (2000) believed that pelvic instability is greatly over-diagnosed and that symphysis pubis pain is transient and resolves spontaneously after delivery, and Ostgaard (1997) wrote that anterior pelvic problems are caused by posterior pelvic malfunction, and that a thorough examination of the pelvis will detect that symphysis pubis pain is always combined with posterior The lack of scientific studies investigating symphysis pubis dysfunction makes it difficult to define the type and area of pain experienced. In the National Clinical Guideline for the Care of Women with Symphysis Pubis Dysfunction, Fry et al., (1997) described the types of symptoms women experience as being mild to severe pain in the pubic region, groin and medial aspect of thighs (unilateral or bilateral); frequently accompanied by sacroiliac, low back and supra-pubic pain. The pain is worst on weightbearing activities (particularly those which involve lifting one leg). Women may also hear or feel a clicking or grinding sensation in the joint, and there is often difficulty walking so a "waddling style" gait is adopted. Mens et al. (1996) conducted a patient survey of 394 patients with pelvic joint pain including pain in the symphysis pubis region, the groin, the greater trochanter, the region of the sacroiliac joints or the lateral parts of the buttocks. Data were obtained by a questionnaire from members of the Dutch Association for Patients with Pelvic Complaints in Relation to Symphysiolysis, and from responses to an advertisement in a magazine. The findings showed that standing for more than 30 minutes was painful for 90% of respondents, and of 15 listed daily activities (including rolling over in bed, getting in and out of bed, carrying shopping, climbing stairs and walking for more than 30 minutes), 14 were painful in more than 45% of the women. Mens et al's results showed that pelvic joint pain seriously interfered with many activities of daily living such as standing, walking and sitting. During a subsequent pregnancy, 85% of the women experienced a relapse of the same pain, and 72% experienced a relapse at the time of menstruation. MacLennan & MacLennan (1997) completed a postal survey of 1115 women (79% response rate) with symptom-giving pelvic joint syndrome of pregnancy and/or postnatal pelvic joint syndrome. The women were all members of the Norwegian Association of Women Suffering from Pelvic Girdle Pain. The commonest sites of pain were the sacroiliac joints and the symphysis pubis but peripheral joints were also often affected. They found that the respondents considered this problem to be severely debilitating and that the problem often continued for many years (mean 6.25 years). The activities that were worst affected were found to be housework, exercise, activities with children, employment, leisure/hobbies and personal relationships or married life. Frequently these effects on the lives of women with symphysis pubis dysfunction were seen as major. Shepherd & Fry (1996) also described women being affected by adverse effects on relationships, decreased ability to care for their baby and family, stress and depression. The length of time women suffer from this condition is variable, resolution may occur in weeks, months or years (MacLennan & MacLennan, 1997; Scriven et al., 1995). Causes of pelvic joint pain
The primary cause of pelvic joint pain during pregnancy is thought to be instability of the pelvic ring due to hormone induced ligamentous laxity and continuous strain on the ligaments of the pelvis. This continuous strain is as a result of the biomechanical changes associated with the increased anterior weight of the growing foetus. These concepts are reviewed in the following paragraphs. The magnitude of symphyseal change
Relaxation of the pelvic joints is an essential and normal part of pregnancy in order to allow the passage of the baby through the pelvis. X-ray studies in the 1930's showed that there is normal symphyseal widening associated with pregnancy. Heyman & Lundqvist (1932) used x-ray techniques to show that the average width of the symphysis pubis in 144 asymptomatic pregnant women was 7-8mm. Roberts (1934) reported the average width of the symphysis pubis (from x-ray measurements) to be 2.6mm in both primiparous women (who had never had children, n=59) and multiparous women (who had previously had children, n=71). In pregnant women, the gap was found to be 4.2mm in primiparous women (n=77) and 5.0mm in multiparous women (n=75). Bjorklund, Bergstrom, Lindgren, & Ulmsten (1996) compared ultrasound and x-ray to measure symphysis pubis width in 15 non-pregnant women of fertile age and found measurements ranging from 1.2 to 4.6mm. Farbrot (1952) measured the vertical gap between the upper medial margins of the pubic bones using x-ray in standing on one leg and found that in 97.2% of 211 women who had given birth (often many years earlier) there was vertical stretching. The average distance was 3.1mm. Of the 37 women studied who had not had children there were only three women who showed any vertical displacement at all. Bjorklund et al. (1999) used ultrasound on 49 pregnant women in a prospective cohort study to determine whether there is a relationship between pregnancy-related pelvic joint pain and degrees of symphyseal laxity. Measurements were taken at 12 and 35 weeks of pregnancy and five months post partum. They also assessed these women for pain in the pelvic joints. The mean width of the symphysis pubis during pregnancy was found to be 3.4mm (SD: 0.8mm) at 12 weeks and 4.8mm (SD: 1.6mm) at 35 weeks. At five months postpartum, the average width had returned to 2.8mm (SD: 1.2mm). There was no evidence that the 49% of women in the study who suffered from pelvic joint pain had wider symphyseal gaps, although the one woman who had a gap of more than ten mm did have pronounced pain. Bjorklund et al concluded that there is a pregnancy induced physiological increase in the laxity of the symphyseal soft tissue, however that there was no evidence that the degree of symphyseal distension determined the severity of pelvic joint pain during pregnancy or after childbirth. Severe dysfunction and pain commonly occur irrespective of clinical evidence of joint dysfunction, and conversely there may be radiological evidence of widening at the top end of the scale that is not associated with clinically severe symptoms (Bjorklund et al., 1999; Ostgaard, 1997). Hormonal effect on ligament laxity
Goldsmith, Weiss, & Steinetz (1995) reported that the involvement of the hormones relaxin, progesterone and oestrogen is frequently cited as being responsible for ligamentous laxity in order to facilitate the opening of the pelvic ring while giving birth. Kristiansson, Svardsudd, & von Schoultz (1996) described relaxin as a peptide hormone of the insulin-like growth factor family, and stated that whilst knowledge of its precise role in humans was still unknown, it has been suggested to have a role in the development of pelvic joint pain in pregnant women by increasing laxity, leading to instability and therefore pain. Like Vleeming et al. (1992a), Wilson (1978) proposed that relaxin has its most marked effect on collagen tissues, and the fact that the dense ligaments of the pelvis are closely packed with collagen cells may explain the presence of relaxin having such a significant effect in this area. However Samuel, Coghlan, & Bateman (1998) showed in rats that the effects of relaxin on the symphysis pubis were independent of the tissue or species type. These authors noted an increase in water content and a decrease in the overall tissue collagen content, thus allowing the tissue to expand and lose its rigidity. Kristiansson et al. (1996) showed that serum relaxin levels were highest in early pregnancy, peaking at approximately 12 weeks, then declining until the 17th week and thereafter remaining stable at about 50% of the peak for the rest of the pregnancy. The same authors found that six months post delivery, serum relaxin was not detectable. Goldsmith et al. (1995) found that relaxin is detectable in human milk six weeks postpartum. Several authors have attempted to correlate relaxin levels with the presence of laxity or pelvic joint pain during pregnancy. Calguneri, Bird, & Wright (1982) showed that ligamentous laxity was increased generally during pregnancy in a study based on finger extension. This was found to be maximal in second and subsequent pregnancies. Schauberger et al. (1996) measured peripheral joint laxity during pregnancy. The measurements taken were knee hyperextension and anterior cruciate ligament excursion, elbow hyperextension, metacarpophalangeal joint hyperextension, index finger distal interphalangeal joint extension and thumb to forearm stretch. The findings showed that anterior cruciate ligament excursion, knee hyperextension, elbow hyperextension and metacarpophalangeal joint hyperextension had either significantly increased laxity or range of motion throughout the pregnancy with levels of 102 to 215 percent of baseline (which was measured prior to pregnancy) being recorded. These levels continued to rise until two weeks post partum, and had decreased (but not to normal, especially in the knee), by six weeks post partum. They were unable to relate these changes to serum relaxin levels. Hansen, Jensen, Larsen, Wilken-Jensen, & Petersen (1996) showed no increase in serum relaxin concentrations at 30 and 36 weeks gestation and two and six months postnatally in patients with symphysis pubis pain versus controls. Conversely, in a study involving 35 women, MacLennan, Nicolson, Green, & Bath (1986) suggested that there is a positive relationship between high mean serum relaxin levels, joint instability and pelvic pain. Similar results were obtained by Kristiansson et al. (1996) who undertook a prospective cohort study with serial measurements of back symptoms, clinical back status and hormone levels in pregnant women sampled from the general population of pregnant women. They found a positive correlation between relaxin levels and pain in the pelvic area, and found similar results from a further study (Kristiansson, Svardsudd, & von Schoultz, 1999). Hence there is currently no agreement on the significance of relaxin in the development of pelvic pain. The onset of symptoms (which varies but is often in the second or third trimester) does not match the levels of hormone present, so it would seem that there are additional factors involved in the aetiology of pelvic joint problems, including symphysis pubis dysfunction, during pregnancy. Biomechanical changes
In advancing pregnancy, the anterior growth of the foetus results in the centre of gravity of the mother moving anteriorly. Vleeming et al. (1995b) described the change in posture as follows: the pregnant woman tries to compensate for anterior weight increase by leaning backwards to regain equilibrium, thus there is anterior iliac rotation which results in relative counternutation of the sacrum and hence instability. Due to the dorsal position of the trunk relative to the pelvic girdle, the function of the gluteal muscles is decreased and therefore the woman walks with a waddling gait (Abitbol, 1997). The growing weight of the uterus and foetus combined with the effect of gravity can result in increased downward force on the pelvic ring. However, this also does not appear to be the primary cause of ligamentous laxity, as pain may begin in the first trimester and does not increase in incidence significantly towards the end of pregnancy as would be expected if the increasing weight of the foetus was the cause of the pain (Mens et al., 1996). Related to the possibility of increased weight of the foetus being a factor, Ostgaard (1997) reported from a review of postnatal literature that peripartum pelvic pain may be associated with the weight of the newborn, that is, heavier babies may lead to more pain. Vleeming et al. (1995b) stated that nutation of the sacrum is painful when the symphysis pubis is painful because it involves compression superiorly and stretching inferiorly. These authors suggested therefore that when there is symphysis pubis pain, the woman may try to adopt a counternutated position in order to avoid nutation because of this inferior ligamentous stretching. This position is unstable and will thus result in further pain by increasing the instability. This is another reason put forward for the waddling style of gait being adopted. That is, it tends to further anteriorly rotate the ilia, thus enhancing counternutation of the sacrum (Vleeming et al., 1997). Changes in muscle during pregnancy
It is commonly suggested in clinical settings (Gleeson & Pauls, 1988) that relaxin has an effect on muscle as well as ligamentous tissue, however a search of the literature has failed to find any evidence to support this conjecture. Very little research describes any muscular changes during pregnancy. The most obvious influence of pregnancy on muscle is the lengthening of the abdominal wall. Due to the location of this muscle group it is affected by the increasing size of the growing uterus, which, as it expands, is accommodated by gross changes in the abdominal wall anatomy (Bullock-Saxton, 1998). The postural changes discussed previously that are associated with pregnancy may also have an affect on the function of muscles. Gilleard & Brown (1996) investigated the structure and function of the abdominal muscles during pregnancy. These authors carried out a study of the abdominal muscles, using rectus abdominis as a representative abdominal muscle (assuming that the adaptation of one muscle does not occur in isolation from other muscles). In order to investigate structural changes, the variables measured were the separation width (diastasis), muscle length and angle of insertion at superior and inferior attachments. Three dimensional photography of abdominal skin markers was used to perform this procedure. Secondly, the functional abilities of the muscles were examined by the ability to perform a curl-up and a posterior pelvic tilt against resistance, and the relationship over time between abdominal muscle function and musculoskeletal adaptations to pregnancy determined. Six primigravid subjects volunteered to be involved in the study. The results showed increases in rectus abdominis muscle separation width, length and angles of insertion as the pregnancy progressed. Abdominal muscle function decreased with time as the muscle lengthened. The maximum mean normalised length of rectus abdominis was 115% at 38 weeks gesatation. These authors assumed that this was a reflection of muscle fibre length increase. In terms of functional ability, by 26 weeks gestation the ability to perform a curl-up exercise had diminished for all subjects and was impossible for all subjects by 38 weeks gestation. These authors also found a decreased ability to perform a posterior pelvic tilt against resistance as pregnancy progresses. Women in this study were fit and exercising throughout pregnancy, therefore results may not be able to be transferred to women who were not fit initially. The effect of pregnancy on other skeletal muscle connective tissue in humans is unclear. Gilleard & Brown (1996) showed that during pregnancy the abdominal muscle lengthening occurs over a period of approximately 22 weeks and therefore the stretch is applied over time. Williams & Goldspink (1971) showed in mice that skeletal muscle fibres add sarcomeres to their length when stretched over time. Conversely shortened muscles show a decrease in sarcomere numbers. These authors also showed that the maximum active tension increased in lengthened muscle and was generated at the new muscle length as the muscle grew. Herring, Grimm, & Grimm (1984) also reported that normal linear growth of vertebrate skeletal muscle fibres proceeds by the serial addition of sarcomeres, and that sarcomere number is highly adjustable (can either increase or decrease). Regulation of sarcomere number is generally considered an adaptation to functional conditions, particularly changes in muscle length. In light of this insight, Gilleard & Brown (1996) suggested that the long term stretch in rectus abdominis during pregnancy may increase muscle length but at the same time maintain maximum active tension. They concluded that the increase in rectus abdominis muscle length was unlikely to greatly reduce the ability to produce tension within the muscle. Hence any functional deficits of the abdominal muscles during pregnancy may result from other factors such as altered line of action rather than from overstretching and thinning. Fast, Weiss, Ducommun, Medina, & Butler (1990) investigated the effect of abdominal muscles and sit-up performance on low back pain during pregnancy. Three hundred and twenty-eight pregnant women were subjects in this study and all had their rectus abdominis length measured using the direct linear transformation method for three dimensional photography to establish the position in space of a series of nine measurement points over rectus abdominis. All subjects were asked to perform one of three types of sit-up. They reported that abdominal muscles during the third trimester of pregnancy were weakened relative to the abdominal muscles of non-pregnant subjects. These authors found no statistically significant correlation between sit-up performance and back-ache. Hence, there is some evidence, albeit limited, to suggest that muscles lengthen but that this lengthening is not necessarily responsible for a change in muscle function. There is a gap in the literature regarding the effect of pregnancy on skeletal muscles Other factors causing pelvic joint pain
Whilst it is generally agreed that the reasons for the temporary dysfunction of the ligamentous system during pregnancy are largely hormonal and related to the increased weight and altered centre of gravity, other contributing factors have been suggested. Mens et al. (1996) used a questionnaire to collect data from 394 members of the Dutch Association for Patients with Pelvic Complaints in Relation to Symphysiolysis. Of the women surveyed 69.9% had their pain labelled as symphysiolysis. They found that women with twin pregnancies were significantly more likely to have peripartum pelvic pain (3.3% of this group compared with 1.4% frequency of twins in the general population). Height and weight of women within the study were similar to that of other pregnant women, suggesting no effect of these factors on pain. The average age of all women with peripartum pelvic pain was 28.6 +/- 3.7 years, and of primiparous women with pain was 27.9 +/- 3.6 years, both of these being 0.5 years older than the values for the Dutch pregnant population. In a survey of 153 members of the Norwegian Association for Women suffering from Pelvic Pain and Pelvic Joint Instability, Saugstad (1991) found that onset of pain was significantly earlier (16.3 weeks) in users of oral contraceptives than non-users (20.5 weeks). MacLennan & MacLennan (1997) surveyed 1609 women from the same association and suggested a strong family history of pelvic joint syndrome was also apparent. These authors raised the possibility of genetic inheritance since the prevalence varied widely in different populations (although this may be related to diagnostic criteria). Heiberg & Aarseth (1997) surveyed 5438 women in Norway between one and four days postpartum (87.2% of women who gave birth during the study period). They reported that women with one child had higher rates of peripartum pelvic pain than those with no previous children (47.7% compared with 32.9% for primiparous women). This increased to 54.4% for women with two previous children. They also suggested that the severity was worse in the women with more children. Fifteen percent of women with two previous children, and 11.1% with one child reported great difficulty with housework compared with 5.3% for women with no children. Furthermore, in women with no children, the onset of peripartum pelvic pain occurred later in the pregnancy. REFERENCES
Abitbol, M. (1997). Quadrupedalism, bipedalism, and human pregnancy. In A. Vleeming, V. Mooney, T. Dorman, C. Snijders, & R. Stoeckart (Eds.), Movement, Stability and Low Back Pain (1st ed., pp. 395-404). Edinburgh: Churchill Livingstone. Abram, S. (2000). Pain pathways and mechanisms. In S. Abram & J. Haddox (Eds.), The Pain Clinic Manual (2nd ed., pp. 13-20). Philadelphia: Lippincott Williams & Wilkins. Berg, G., Hammar, M., Moller-Nielson, J., Linden, U., & Thorbold, J. (1988). Low back pain during pregnancy. Obstetrics and Gynecology, 71(1), 71-76. Bergmark, A. (1989). Stability of the lumbar spine. A study in mechanical engineering. Acta Orthopaedica Scandinavia, 230(60(Suppl)), 20-24. Beurskens, A., de Vet, H., & Koke, A. (1996). Responsiveness of functional status in low back pain: a comparison of different instruments. Pain, 65, 71-76. Beurskens, A., de Vet, H., Koke, A., van der Heijden, G., & Knipschild, P. (1995). Measuring the functional status of patients with low back pain: assessment of quality of four disease-specific questionnaires. Spine, 20(9), 1017-1028. Bjorklund, K., Bergstrom, S., Lindgren, P., & Ulmsten, U. (1996). Ultrasonographic measurement of the symphysis pubis: a potential method of studying symphyseolysis in pregnancy. Gynecological and Obstetric Investigations, 42, 151-153. Bjorklund, K., Nordstrom, M., & Bergstrom, S. (1999). Sonographic assessment of symphyseal joint distension during pregnancy and post partum with special reference to pelvic pain. Acta Obstetricia et Gynecologica Scandinavica, 78, 125-30. Bowsher, D. (1994). Nociceptors and peripheral nerve fibres. In P. Wells, V. Frampton, & D. Bowsher (Eds.), Pain Management by Physiotherapy (2nd ed., pp. 44-46). Oxford: Butterworth Heinemann. Bullock-Saxton, J. (1998). Musculoskeletal changes associated with the perinatal period. In R. Sapsford, J. Bullock-Saxton, & S. Markwell (Eds.), Women's Health - A Textbook for Physiotherapists (pp. 134-61). London: WB Saunders Company Ltd. Burke, D., Gandevia, S., & Macefield, G. (1988). Responses to passive movement of receptors in joint , skin and muscle of the human hand. Journal of Physiology, 402, 347-361. Calguneri, M., Bird, H., & Wright, V. (1982). Changes in joint laxity occurring during pregnancy. Annals of the Rheumatic Diseases, 41, 126-128. Carroll, T., Riek, S., & Carson, R. (2001). Neural adaptations to resistance training - implications for movement control. Sports Medicine, 31(12), 829-840. Cavanaugh, J. (1995). Neural mechanisms of lumbar pain. Spine, 20(16), 1804-1809. Cholewicki, J., & McGill, S. (1996). Mechanical stability of the in vivo lumbar spine: implications for injury and chronic low back pain. Clinical Biomechanics, 11(1), 1-15. Clark, F., Horch, K., & Bach, S. (1979). Contributions of cutaneous and joint receptors to static position sense in man. Journal of Neurophysiology, 42, 877-888. Deyo, R. (1993). Practice variations, treatment fads, rising disability: do we need a new clinical research paradigm. Spine, 18(15), 2153-2162. Deyo, R., Battie, M., Beurskens, A., & al, e. (1998). Outcome measures for low back pain research: a proposal for standardised use. Spine, 23, 2003-13. Dhar, S., & Anderton, J. (1992). Symphysis pubis rupture during labor. Clinical Orthopedics and Related Research, 283, 252-257. DonTigny, R. (1995). Mechanics and treatment of the sacroiliac joint. Paper presented at the Second Interdisciplinary World Congress on Low Back Pain: The Integrated Function of the Lumbar Spine and Sacroiliac Joint., San Diego, CA. Dumas, G., Reid, J., Wolfe, L., Griffen, M., & McGrath, M. (1995). Exercise, posture, and back pain during pregnancy: part 2. exercise and back pain. Clinical Biomechanics, 10, 104-109. Dvorak, J., Panjabi, M., Novotny, J., Chang, D., & Grob, D. (1991). Clinical validation of functional flexion-extension roentgenograms of the lumbar spine. Spine, 16(8), 943-950. Edin, B., & Abis, J. (1991). Finger movement responses of cutaneous mechanoreceptors in the dorsal skin of the human hand. Journal of Neurophysiology, 65(3), 657-666. Edin, B. (1992). Quantitative analysis of static strain sensitivity in human mechanoreceptors from hairy skin. Journal of Neurophysiology, 67(5), 1105-13. Farbrot, E. (1952). The relationship of the effect and pain of pregnancy to the anatomy of the pelvis. Acta Radiologica, 38, 403-17. Fast, A., Weiss, L., Ducommun, E., Medina, E., & Butler, J. (1990). Low back pain in pregnancy - abdominal muscles, sit-up performance, and back pain. Spine, 15(1), 28-30. Ferrell, W., & Craske, B. (1992). Contribution of joint and muscle afferents to position sense at the human proximal interphalangeal joint. Experimental Physiology, 77, 331-342. Fleiss, J. (1981). Statistical methods for rates and proportions. (2nd ed.). New York: Friberg, O. (1987). Lumbar instability: a dynamic approach by traction-compression radiography. Spine, 12(2), 119-129. Fritz, J., Erhard, R., & Hagen, B. (1998). Segmental instability of the lumbar spine. Physical Therapy, 78(8), 889-896. Fry, D., Hay-Smith, J., Hough, J., McIntosh, J., Polden, M., Shepherd, J., & Watkins, Y. (1997). National clinical guideline for the care of women with symphysis pubis dysfunction. Midwives, 110(1314), 172-3. Fry, D. (1999). Perinatal symphysis pubis dysfunction: a review of the literature. Journal of the Association of Chartered Physiotherapists in Women's Health, 85, 11-18. Gamble, J., Simmons, S., & Freedman, M. (1986). The symphysis pubis. Clinical Orthopedics and Related Research, 203, 261-272. Gilleard, W., & Brown, J. (1996). Structure and function of the abdominal muscles in primigravid subjects during pregnancy and the immediate postbirth period. Physical Therapy, 76(7), 750-762. Gleeson, P., & Pauls, J. (1988). Obstetrical Physical Therapy: review of the literature. Physical Therapy, 68, 1699-1702. Goldsmith, L., Weiss, G., & Steinetz, B. (1995). Relaxin and its role in pregnancy. Endocrinology and Metabolism Clinics of North America, 24(1), 171-183. Grob, K., Neuhuber, W., & Kissling, R. (1995). Innervation of the sacroiliac joint of the human. Zeitschrift fur Rheumatologie, 54(2), 117-22. Hall, M., Ferrell, W., Sturrock, R., Hamblen, D., & Baxendale, R. (1995). The effect of the hypermobility syndrome on knee joint proprioception. British Journal of Rheumatology, 34(2), 121-5. Hansen, A., Jensen, D., Larsen, E., Wilken-Jensen, C., & Petersen, L. (1996). Relaxin is not related to symptom-giving pelvic girdle relaxation in pregnant women. Acta Obstetricia et Gynecologica Scandinavica, 75, 245-249. Heiberg, E., & Aarseth, S. (1997). Epidemiology of pelvic pain and low back pain in pregnant women. In A. Vleeming, V. Mooney, T. Dorman, C. Snijders, & R. Stoeckart (Eds.), Movement, Stability and low back pain (1st ed., pp. 405-410). Edinburgh: Churchill Livingstone. Herring, S., Grimm, A., & Grimm, B. (1984). Regulation of sarcomere number in skeletal muscle: a comparison of hypotheses. Muscle and Nerve, 7, 161-173. Heyman, J., & Lundqvist, A. (1932). The symphysis pubis in pregnancy and parturition. Acta Obstetricia et Gynecelogica Scandinavica, 12, 191-226. Hodges, P. (1999). Is there a role for transversus abdominis in lumbo-pelvic stability? Manual Therapy, 4(2), 74-86. Hodges, P., & Richardson, A. (1996). Inefficient muscular stabilisation of the lumbar spine associated with low back pain. Spine, 21, 2640-2650. Hodges, P., & Richardson, C. (1997). Contraction of the abdominal muscles associated with movement of the upper limb. Physical Therapy, 77, 132-142. Jensen, M., Karoly, P., & Braver, S. (1986). The measurement of clinical pain intensity: a comparison of six methods. Pain, 27, 117-126. Jessell, T., & Kelly, D. (1991). Pain and analgesia. In E. Kandel, J. Schwartz, & T. Jessel (Eds.), Principles of neural science (3rd ed., pp. 385-399). Connecticut: Appleton & Lange. Johansson, H., & Sjolander, P. (1993). Neurophysiology of joints. In V. Wright & E. Radin (Eds.), Mechanics of Human Joints . New York: Marcel Dekker Inc. Kharrazi, F., Rodgers, W., Kennedy, J., & Lhowe, D. (1997). Parturition-induced dislocation: a report of four cases. Journal of Orthopaedic Trauma, 11(4), 277-282. Kopec, J., & Esdaile, J. (1995). Functional disability scales for back pain. Spine, 20(17), 1943-49. Kopec, J., Esdaile, J., Abrahamowicz, M., Abenhaim, L., Wood-Dauphinee, S., Lamping, D., & Williams, I. (1995). The Quebec Back Pain Disability Scale: measurement properties. Spine, 20(3), 341-52. Kopec, J. (2000). Measuring functional outcomes in persons with back pain. Spine, 25(24), 3110-4. Kowalk, D., Perdue, P., Bourgeois, F., & Whitehill, R. (1996). Disruption of the symphysis pubis during vaginal delivery - a case report. Journal of Bone and Joint Surgery, 78A(11), 1746-8. Kristiansson, P., Svardsudd, K., & von Schoultz, B. (1996). Serum relaxin, symphyseal pain, and back pain during pregnancy. American Journal of Obstetrics and Gynecology, 175(5), 1342-1347. Kristiansson, P., Svardsudd, K., & von Schoultz, B. (1999). Reproductive hormones and aminoterminal propeptide of type III procollagen in serum as early markers of pelvic pain during pregnancy. American Journal of Obstetrics and Gynecology, 180(1), 128-134. Kubitz, R., & Goodlin, R. (1986). Symptomatic separation of the pubic symphysis. Southern Medical Journal, 79(5), 578-580. Lantz, S., & Schultz, A. (1986). Lumbar spine orthosis wearing: restriction of gross body motion. Spine, 11, 834-7. Laskowski, E., Newcomer-Aney, K., & Smith, J. (2000). Proprioception. Physical Medicine and Rehabilitation Clinics of North America, 11(2), 323-40. Laslett, M., & Williams, M. (1994). The reliability of selected pain provocation tests for sacroiliac joint pathology. Spine, 19(11), 1243-1249. Leclaire, R., Blier, F., Fortin, L., & Proulx, R. (1997). A cross-sectional study comparing the Oswestry and Roland-Morris functional disability scales in two populations of patients with low back pain of different levels of severity. Spine, 22(1), 68-71. Lee, D. (1996). Instability of the sacroiliac joint and the consequences to gait. The Journal of Manual and Manipulative Therapy, 4(1), 22-29. Lee, Y.-H., & Chen, C.-Y. (2000). Belt effects on lumbar sagittal angles. Clinical Biomechanics, 15, 79-82. Lindsey, R., Leggon, R., Wright, D., & Nolasco, D. (1988). Separation of the symphysis pubis in association with childbearing. Journal of Bone and Joint Surgery, 70a(2), 289-292. Luger, E., Arbel, R., & Dekel, S. (1995). Traumatic separation of the symphysis pubis during pregnancy: a case report. The Journal of Trauma: Injury, Infection and Critical Care, 38(2), 255-6. MacLennan, A., Nicolson, R., Green, R., & Bath, M. (1986). Serum relaxin and pelvic pain of pregnancy. The Lancet, ii, 243-45. MacLennan, A., & MacLennan, S. (1997). Symptom-giving pelvic girdle relaxation of pregnancy, postnatal pelvic joint syndrome and developmental dysplasia of the hip. Acta Obstetricia et Gynecologica Scandinavica, 76, 760-764. Magee, D. (1992). Orthopedic Physical Assessment. (2nd ed., p 327). Philadelphia: WB Saunders Company. Mallik, A., Ferrell, W., McDonald, A., & Sturrock, R. (1994). Impaired proprioceptive acuity at the proximal interphalangeal joint in patients with the hypermobility syndrome. British Journal of Rheumatology, 33(7), 631-7. Mantle, M., Holmes, J., & Currey, H. (1981). Backache in pregnancy II: prophylactic influence of back care classes. Rheumatology and Rehabilitation, 20, 227-232. McLain, R., & Pickar, J. (1998). Mechanoreceptor endings in human thoracic and lumbar facet joints. Spine, 23(2), 168-73. McNair, P., Stanley, S., & Strauss, G. (1996). Knee bracing: effects on proprioception. Archives of Physical Medicine and Rehabilitation, 77, 287-289. McNair, P., & Heine, P. (1999). Trunk proprioception: enhancement through lumbar bracing. Archives of Physical Medicine and Rehabilitation, 80, 96-99. McNair, P. (2000). Bracing the athletes back: efficacy and indications. International Journal of Sports Medicine, 1(4). Mens, J., Snijders, C., & Stam, H. (2000). Diagonal trunk muscle exercises in peripartum pelvic pain: a randomised clinical trial. Physical Therapy, 80(12), 1164-1172. Mens, J., Vleeming, A., Stoeckart, R., Stam, H., & Snijders, C. (1996). Understanding peripartum pelvic pain - implications of a patient survey. Spine, 21(11), 1363-1370. Mens, J., Vleeming, A., Snijders, C., & Stam, H. (1997). Active straight leg raising test: a clinical approach to the load transfer function of the pelvic girdle. In A. Vleeming, V. Mooney, T. Dorman, C. Snijders, & R. Stoeckart (Eds.), Movement, Stability and Low Back Pain (1st ed., pp. 425-432). Edinburgh: Churchill Livingstone. Meyer, R., Campbell, J., & Raja, S. (1994). Peripheral neural mechanisms of nociception. In P. Wall & R. Melzack (Eds.), Textbook of Pain (3rd ed., pp. 13-44). Edinburgh: Churchill Livingstone. Mooney, V. (1997). Sacroiliac joint dysfunction. In A. Vleeming, V. Mooney, T. Dorman, C. Snijders, & R. Stoeckart (Eds.), Movement, Stability and Low Back Pain (pp. 37-52). Edinburgh: Churchill Livingstone. Mooney, V., Pozos, R., Vleeming, A., Gulick, J., & Swenski, D. (2001). Exercise treatment for sacroiliac pain. Orthopedics, 24(1), 29-32. Moritani, T. (1993). Neuromuscular adaptations during the acquisition of muscle strentgh, power and motor tasks. Journal of Biomechanics, 26(Suppl 1), 95-107. Musumeci, R., & Villa, E. (1994). Symphysis pubis separation during vaginal delivery with epidural anesthesia: case report. Regional Anesthesia, 19(4), 289-91. Newcomer, K., Laskowski, E., Yu, B., Johnson, J., & An, K. (2001). The effects of a lumbar support on repositioning error in subjects with low back pain. Archives of Physical Medicine and Rehabilitation, 82(7), 906-10. Nilsson-Wikmar, L., Holm, K., Oijerstedt, R., & Harms-Ringdahl, K. (1998). Effects of different treatments on pain and on functional activities in pregnant women with pelvic pain. Paper presented at the Third Interdisciplinary World Congress on Low Back and Pelvic Pain, Vienna. Noren, L., Ostgaard, S., Nielsen, T., & Ostgaard, H. (1997). Reduction of sick leave for lumbar back and posterior pelvic pain in pregnancy. Spine, 22(18), 2157-2160. Ostgaard, H., Zetherstrom, G., Roos-Hansson, E., & Svanberg, B. (1994). Reduction of back and posterior pelvic pain in pregnancy. Spine, 19(8), 894-900. Ostgaard, H. (1997). Lumbar back and posterior pelvic pain in pregnancy. In A. Vleeming, V. Mooney, T. Dorman, C. Snijders, & R. Stoeckart (Eds.), Movement, Stability and Low Back Pain (1st ed., pp. 411-420). Edinburgh: Churchill Livingstone. O'Sullivan, P. (2000). Lumbar segmental "instability": clinical presentation and specific stabilising exercise management. Manual Therapy, 5(1), 2-12. Panjabi, M. (1992). The stabilising system of the spine, part 1: function, dysfunction, adaptation and enhancement. Journal of Spinal Disorders, 5, 383-389. Patrick, D., Deyo, R., Atlas, S., Singer, D., Chapin, A., & Keller, R. (1995). Assessing health-related quality of life in patients with sciatica. Spine, 20(17), 1899-1909. Pool-Goudzwaard, A., Vleeming, A., Stoeckart, R., Snijders, C., & Mens, J. (1998). Insufficient lumbopelvic stability: a clinical, anatomical and biomechanical approach to 'a-specific' low back pain. Manual Therapy, 3(1), 12-20. Ravin, T. (1997). Visualisation of pelvic biomechanical dysfunction. In A. Vleeming, V. Mooney, T. Dorman, C. Snijders, & R. Stoeckart (Eds.), Movement, Stability and Low Back Pain (1st ed., pp. 369-384). Edinburgh: Churchill Livingstone. Renckens, C. (2000). Between hysteria and quackery: some reflections on the Dutch epidemic of obstetric 'pelvic instability'. Journal of Psychosomatic Obstetrics and Gynecology, 21, 235-239. Roberts, R. (1934). Discussion on the physiology and pathology of the pelvic joints in relation to child-bearing. A radiological investigation. Proceedings of the Royal Society of Medicine, 27, 1217-1225. Roberts, S., Eisenstein, S., Menage, J., Evans, E., & Ashton, I. (1995). Mechanoreceptors in intervertebral discs. Morphology, distribution and neuropeptides. Spine, 20(24), 2645-51. Roland, M., & Morris, R. (1982). A study of the natural history of back pain. Part 1: development of a reliable and sensitive measure of disability in low-back pain. Spine, 8(2), 141-44. Roland, M., & Fairbank, J. (2000). The Roland-Morris Disability Questionnaire and the Oswestry Disability Questionnaire. Spine, 25(24), 3115-24. Saal, J. (1995). The role of inflammation in lumbar pain. Spine, 20(16), 1821-1827. Sakamoto, N., Yamashita, T., Takebayashi, T., Sekine, M., & Ishii, S. (2001). An electrophysiologic study of mechanoreceptors in the sacroiliac joint. Spine, 26, E468-471. Sale, D. (1986). Neural adaptation in strength and power training. In N. Jones, N. McCartney, & A. McComas (Eds.), Human muscle power (pp. 289-304). Champaign: Human Kinetics Publishers, Inc. Sale, D. (1988). Neural adaptation to resistance training. Medicine and Science in Sports and Exercise, 20(5 Suppl), 135-45. Samuel, C., Coghlan, J., & Bateman, J. (1998). Effects of relaxin, pregnancy and parturition on collagen metabolism in the rat pubic symphysis. Journal of Endocrinology, 159, 117-125. Sapsford, R., Hodges, P., & Richardson, C. (1997a). Activation of the abdominal muscles is a normal response to contraction of the pelvic floor muscles. Paper presented at the International Continence Society Conference, Japan. Sapsford, R., Hodges, P., Richardson, C., Cooper, D., Jull, G., & Markwell, S. (1997b). Activation of pubococcygeus during a variety of isometric abdominal exercises. Paper presented at the International Continence Society Conference, Japan. Sapsford, R. (2001). The pelvic floor: a clinical model for function and rehabilitation. Physiotherapy, 87(12), 620-630. Saugstad, L. (1991). Persistent pelvic pain and pelvic joint instability. European Journal of Obstetrics & Gynecology and Reproductive Biology, 41, 197-201. Schaible, H., & Schmidt, R. (1985). Effects of an experimental arthritis on the sensory properties of fine articular afferent units. Journal of Neurophysiology, 54, 1109-22. Schauberger, C., Rooney, B., Goldsmith, L., Shenton, D., Silva, P., & Schaper, A. (1996). Peripheral joint laxity increases in pregnancy but does not correlate with serum relaxin levels. American Journal of Obstetrics and Gynecology, 174, 667-671. Schwartz, Z., Katz, Z., & Lancet, M. (1985). Management of puerperal separation of the symphysis pubis. International Journal of Gynaecology and Obstetrics, 23, 125-128. Scriven, M., Jones, D., & McKnight, L. (1995). The importance of pubic pain following childbirth: a clinical and ultrasonographic study of diastasis of the pubic symphysis. Journal of the Royal Society of Medicine, 88, 28-30. Sekine, M., Mamashita, T., Takebayashi, T., Sakamoto, N., Minaki, Y., & Ishii, S. (2001). Mechanosensitive afferent units in the lumbar posterior longitudinal ligament. Spine, 26(14), 1516-1521. Shepherd, J., & Fry, D. (1996). Symphysis pubis pain. Midwives, 109(1302), 199-201. Sheppard, S. (1997). Symphysis pubis dysfunction: launch of clinical guidelines. Journal of the Association of Chartered Physiotherapists in Women's Health, 81, 29-33. Siddall, P., & Cousins, M. (1995). Pain mechanisms and management: an update. Clinical and Experimental Pharmacology and Physiology, 22, 679-688. Snijders, C., Vleeming, A., & Stoeckart, R. (1993). Transfer of lumbosacral load to iliac bones and legs. Part 1: Biomechanics of self-bracing of the sacroiliac joints and its significance for treatment and exercise. Clinical Biomechanics, 8, 285-294. Snijders, C., Slagter, A., van Strik, R., Vleeming, A., Stoeckart, R., & Stam, H. (1995). Why leg crossing? The influence of common postures on abdominal muscle activity. Spine, 20(18), 1989-1993. Snijders, C., Vleeming, A., Stoeckart, R., Mens, J., & Kleinrensink, G. (1997). Biomechanics of the interface between spine and pelvis in different postures. In A. Vleeming, V. Mooney, T. Dorman, C. Snijders, & R. Stoeckart (Eds.), Movement, Stability and Low Back Pain (1st ed., pp. 103-114). Edinburgh: Churchill Livingstone. Snow, R., & Neubert, A. (1997). Peripartum pubic symphysis separation: a case series and review of the literature. Obstetrical and Gynecological Survey, 52(7), 438-443. Stratford, P., & Binkley, J. (1997). Measurement properties of the RM-18 A modified version of the Roland-Morris disability scale. Spine, 22(20), 2416-2421. Stratford, P., Binkley, J., Riddle, D., & Guyatt, G. (1998). Sensitivity to change of the Roland-Morris back pain questionnaire: part 1. Physical Therapy, 78(11), 1186-1196. Taylor, R., & Sonson, R. (1986). Separation of the symphysis pubis - an underrecognised peripartum complication. Journal of Reproductive Medicine, 31(3), 203-206. Tesh, K. (1987). The abdominal muscles and vertebral stability. Spine, 12, 501-508. Vleeming, A., Wingerden, J. v., Snijders, C., Stoeckart, R., & Stijnen, T. (1989). Load application to the sacrotuberous ligament: influences on sacroiliac joint mechanics. Journal of Clinical Biomechanics, 4, 204-209. Vleeming, A., Stoeckart, R., Volkers, A., & Snijders, C. (1990). Relation between form and function in the sacroiliac joint. Part 1: clinical anatomical aspects. Spine, 15(2), 130-132. Vleeming, A., Buyruk, H., Stoeckart, R., Karamursel, S., & Snijders, C. (1992a). An integrated therapy for peripartum pelvic instability: a study of the biomechanical effects of pelvic belts. American Journal of Obstetrics and Gynecology, 166(4), 1243-1247. Vleeming, A., Van Wingerden, J., Dijkstra, P., Stoeckart, R., Snijders, C., & Stijnen, T. (1992b). Mobility in the sacroiliac joints in the elderly; a kinematic and radiological study. Clinical Biomechanics, 7, 170-176. Vleeming, A., Pool-Goudzwaard, A., Stoeckart, R., van Wingerden, J., & Snijders, C. (1995a). The posterior layer of the thoracolumbar fascia. Spine, 20(7), 753-758. Vleeming, A., Snijders, C., Stoeckart, R., & Mens, J. (1995b). A new light on low back pain. Paper presented at the 2nd Interdisciplinary World Congress on Low Back Pain, Rotterdam, ECO. Vleeming, A., Pool-Goudzwaard, A., Hammudoghlu, D., Stoeckart, R., Snijders, C., & Mens, J. (1996). The function of the long dorsal sacroiliac ligament - its implication for understanding low back pain. Spine, 21(5), 556-562. Vleeming, A., Snijders, C., Stoeckart, R., & Mens, J. (1997). The role of the sacroiliac joints in coupling between spine, pelvis, legs and arms. In A. Vleeming, V. Mooney, T. Dorman, C. Snijders, & R. Stoeckart (Eds.), Movement, Stability and low back pain (1st ed., pp. 53-72). Edinburgh: Churchill Livingstone. Wedenberg, K., Moen, B., & Norling, A. (2000). A prospective randomized study comparing acupuncture with physiotherapy for low back and pelvic pain during pregnancy. Acta Obstetricia et Gynecologica Scandinavica, 79, 331-335. Westaway, M., Stratford, P., & Binkley, J. (1998). The patient-specific functional scale; validation of its use in persons with neck dysfunction. Journal of Orthopedic and Sports Physical Therapy, 27(5), 331-8. Willard, F. (1997). The muscular, ligamentous and neural structure of the low back and its relation to back pain. In A. Vleeming, V. Mooney, T. Dorman, C. Snijders, & R. Stoeckart (Eds.), Movement, Stability and Low Back Pain (1st ed., pp. 3-36). Edinburgh: Churchill livingstone. Williams, P., & Goldspink, G. (1971). Longitudinal growth of striated muscle fibres. Journal of Cellular Science, 9, 751-767. Wilson, G. (1978). Diastasis of the pubic symphysis with special consideration of pregnancy and parturition. South African Journal of Physiotherapy, 34(4), 13-14. Yamashita, T., Cavanaugh, J., El-Bohy, A., Getchell, T., & King, A. (1990). Mechanosensitive afferent units in the lumbar facet joint. Journal of Bone and Joint Surgery, 72A(6), 865-870. Yamashita, T., Minaki, Y., Oota, I., Yokogushi, K., & Ishii, S. (1993). Mechanosensitive afferent units in the lumbar intervertebral disc and adjacent muscle. Spine, 18(15), 2252-2256.



WASTE CONTAMINATION FROM SALMON FARMS Tens of thousands of farmed salmon confined to net pens produce a huge amount of waste: chemical, biological, organic, and inorganic. For more than 25 years, researchers around the world have recognized the harm from salmon farm waste and its long-term impacts on water quality, fisheries resources, and sea-bed ecology.1 THE WASTE PROBLEMSalmon net pens discharge untreated sewage, including contaminated feed laced with chemi-cals, toxic residues, nitrogen, phosphorus, and copper and zinc—not to mention diseases and parasites—directly into coastal waters throughout the world. In addition, tons of contaminated salmon, together with processing wastes—bones, entrails, and even the carcasses of seals, sea lions, and other predators—are dumped in landfills or processed for fertilizer or animal feed.

Microsoft word - 4[1]_7__91_109 _rostami _2_

Iranian Journal of Mathematical Chemistry, Vol. 4, No. 1, March 2013, pp. 91 − 109 QSAR Modeling of Antimicrobial Activity with Some Novel 1,2,4- Triazole Derivatives, Comparison with Experimental Study AHRA ROSTAMI , ABBAS AMINI MANESH AND LEILA SAMIE Department of Chemistry, Payame Noor University, I. R. of Iran