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"Deutsche Standards": Brands of the Century 2016 In 2016 BRITA was inducted into the rank of Brands of the Century by publisher Deutsche Standards. The brand compendium "Brands of the Century" by Cologne-based publishing house Deutsche Standards has been in print for over 20 years. It presents German brands from all kinds of different product segments that are deemed to be the strongest. The guiding theme of the 2016 edition is "stars". The Deutsche Standards press release reads: "The brands honoured here are above all the stars in the endless brand sky, which shine particularly brightly and convey to the consumer a sense of orientation, quality and also brand history in a unique way." Company of the month The state government of Hessen in Germany chose BRITA as its company of the month for January 2014. As part of its campaign "Committed company – stimulating Hessen", every month the state presents this award to one company whose exemplary commitment has attracted attention in its social environment. On behalf of State Premier Volker Bouffier, the state government praised the large number of activities in which BRITA is engaged for more than 25 years, becoming heavily involved in the areas of social commitment, sport and culture. BRITA works with disabled workshops at both regional and national level, helping to fund schools, kindergartens, music societies, charities and charity events. Additionally, for many years now BRITA has been sponsoring arts and sports – primarily in cooperation with the soccer club SV Wehen Wiesbaden. Throughout the world, the BRITA Group backs social initiatives connected with all aspects of water and nutrition. www.brita.net Page 1 / 10





2011 Grünes Band (Green Ribbon) In February 2011 BRITA received the "Green Ribbon" for the consistent way we have anchored sustainability in its corporate concept. This sustainability prize for the out-of-home market was awarded for the first time in 2011by trade media publishing house Huss-Medien. The jury was particularly impressed by how early our company offered 100% recyclable cartridges (as of 1992), by its consistent switch from hydroelectric power to certified green electricity, and by its manifold social commitments. The "Green Ribbon" prize is awarded by specialist magazines "GV kompakt" and "gastronomie & hotellerie Das Unternehmermagazin", both published by Huss, and is divided into six categories: "Ecology", "Fair Trade", "Climate", "Energy", "Water", and "Corporate Concept". Footprint Awards 2015 – Sustainable Supplier Award – Winner The Footprint Awards recognize innovative ways that businesses and individuals are making a difference to sustainability in the foodservice industry. The entry highlighted activity undertaken in the UK to achieve zero waste to landfill and BRITA's ongoing commitment to carbon reduction through its companywide dedicated CSR programme. Vending Awards 2014 – The Best Environmental Initiative – Winner The Best Environmental Initiative Award recognizes environmental excellence. The award entry highlighted BRITA's ongoing commitment to sustainable practises; including a comprehensive recycling programme scheme which sees over 400 tonnes of plastic recycled each year across BRITA Group and a zero landfill scheme in the UK.



National Recycling Gold Star BRITA UK received the gold "National Recycling Star" at the end of 2013, valid for one year. The prize is awarded at a high-visibility event organized by the E2B Group, a private network committed to lowering carbon emissions. It helps companies to improve their environmental track record and, at the same time, to cut costs. One extremely important aspect is reducing the amount of waste produced. After extensive preparations, BRITA UK has succeeded in fulfilling all criteria for the highest level of the "National Recycling Star" – complete avoidance of non-recyclable waste, the introduction of measures to maximize the recycling of waste material, the creation of greater "waste consciousness" in the company, and the involvement of staff in the improvement of waste management. red dot design award In 2016, international design experts chose the new jug water filter BRITA fill&enjoy Fun as the recipient of the reputed "red dot design award". The "red dot design award" is bestowed by a distinguished jury as part of the world's largest and best-known design competition. In 2015, it was the water filter carafe BRITA fill&serve Mind that already received the red dot seal of approval. In 2014, the filter bottle BRITA fill&go Vital, 2012 the BRITA product BRITA yource, 2010 the enviva drinking furniture series produced by BRITA Ionox Deutschland GmbH won the award. One year earlier the Navelia water filter jug was selected for this high-calibre prize, on the basis of evaluation criteria such as degree of innovativeness, functionality, self-explanatory quality and compatibility with the environment. Pro-K award Following the Red Dot Award in 2015, at the start of 2016 the BRITA fill&serve Mind water filter carafe scooped yet another prize: the pro-K award for quality in plastic. Some 200 products were entered for the pro-K award 2016. There are eleven categories ranging from office supplies, toys, and garden articles to home fittings, coating, storage, and transport systems. The BRITA fill&serve Mind was submitted in the "Indoor" category, which incorporates living area, kitchen, and bathroom. A jury made up of 13 experts from industry and retail, research and quality inspection, design and the press, and DHB-Netzwerk Haushalt (the German Association of Homemakers) was responsible for appraising the entries. In the jury's reasoning functionality accounted for 40 percent of the overall score, and design and innovation for 30 percent each. And this is how the jury's judgement declaring the BRITA fill&serve Mind to be the winner read: "A clear formal idiom with ingenious elements. The classic carafe skilfully crafted in plastic". Good Design Award In October 2008, the BRITA water filter jug "Navelia" was the recipient of the Japanese "Good Design award" in the category "Eating, kitchens, cooking, household products and appliances". This sought-after design prize, for which that year there were 3,023 entries, is awarded by the Japan Industrial Promotion Organization (JIDPO). The accolade stands for the sort of design that "stimulates the sector" and "is life-enriching". Another award followed in 2011, this time for the "On Line Active" built-in filter in the category "Miscellaneous and household products and appliances". iF design award In February 2014 Industrieforum Design honoured the BRITA Fill&Go water bottle with the "iF design award" in the product category Product Design. Industrieforum Design, an independent industrial forum, has a very good reputation on the German design scene, its declared objective being to promote good design and to anchor design as a success factor in the consciousness of both business and the public. Accordingly, the association regularly recognizes outstanding design achievements in the disciplines Products, Communication, and Packaging. With more than 20,000 entries from over 50 countries submitted every year, the iF awards are amongst the largest and most important international design prizes. The BRITA Fill&Go was entered in the section "Leisure and Lifestyle" and assessed using various criteria such as design quality, finish, choice of materials, environmental impact, ergonomics, degree of innovation, and brand value.


Kitchen Innovation of the Year 2013 In February 2013, the BRITA Tap was chosen as the "Kitchen Innovation of the Year 2013" at the "Ambiente" consumer goods fair in Frankfurt/Main. The prize is awarded by "LifeCare", an independent initiative whose objective is to enhance people's quality of life with regard to cooking and nutrition, lifestyle and living environment. After a specialist jury has selected outstanding products in various categories using a standardized procedure, a market research institute polls consumers who ultimately decide how the prizes are awarded. The prize was awarded for functionality, innovation, design and ecology. Trusted Brand Award In 2013 consumers in Taiwan chose BRITA as the brand they trusted for the sixth time. In the "Trusted Brand" consumer survey conducted by "Reader's Digest" magazine since 1999, every year readers' favourite brands are determined in eight Asian countries – China, Hong Kong, India, Malaysia, Singapore, Taiwan, Thailand and the Philippines. BRITA impressed the consumers in the product category "Water purifiers". The prize was awarded on the basis of a questionnaire using the criteria "trustworthiness and credibility", "innovation", "quality", "value", "social responsibility" and "understanding of consumer needs". If, as was the case with BRITA, a company's results are considerably better than those of their competitors, the brand receives the "Gold Trusted Brand Award". The poll, which is conducted by market researchers Ipsos, enjoys a very good reputation. It provides companies with information about how much customers trust their brand and offers consumers a reliable basis for purchasing decisions. Superbrands BRITA took its place on the coveted list of the 500 superbrands in Great Britain in 2006 and 2008. The list is published annually in recognition of outstanding consumer brands. After a preliminary selection by a forum of experts, the "superbrands" committee, BRITA was initially elected to the circle of brands that could qualify for inclusion in the top 500. The list of the TOP 500 finalists is ultimately compiled in cooperation with a British market research agency, YouGov. YouGov asks British consumers which brand they would consider "superbrands". The definition of superbrands is brands that "enjoy the highest reputation in their particular market segments, that offer consumers both emotional and concrete advantages over other brands, and that are sought out and appreciated by consumers (be this consciously or unconsciously)". Best Non-Coffee Supplier Europe 2012 At the "Allegra European Coffee Award" ceremony in Amsterdam in November 2012 BRITA Professional was awarded first prize in the "Best Non-Coffee Supplier Europe", ahead of Solo Cup Europe and Coca-Cola. The "Allegra European Coffee Awards" recognize those companies and individuals who make an outstanding contribution to the market segments "coffee" and "food to go". The organizer of the prize, Allegra Events Ltd. in London, asked more than 10,000 executives in the industrial sector to supply their suggestions for various categories. Prizes are awarded at both national and European level. Deutscher Project Excellence Award 2011 On 25 October 2011, BRITA received the sought-after "Deutscher Project Excellence Award 2011" presented by project management association GPM at a prize-giving ceremony at the 2011 PM Forum in Nuremberg, Germany. The accolade was in recognition of a team of BRITA staff members' successful project work in developing a new kind of product for the company. The objective of the "Countertop" project was, within only 24 months, to develop an electrical household appliance that produces soft drinks "similar to water" on the basis of a capsule system and BRITA-optimised water. In addition to developing the appliance and the capsules in a total of nine different flavours, the project involved filling the capsules and the strategy for marketing, selling and communicating the product. Award-winning customer management In this specialist field, BRITA has already received high accolades for its integrated customer relationship management and e-commerce system on two occasions: in June 2011 the system was presented with the "Best Practice Award Business Intelligence und Data Warehousing", followed in November of the same year by the "CRM Best Practice Award", which confirmed that BRITA offered the "best customer management in 2011". Every year, the "CRM Best Practice Award" honours exemplary solutions in customer relationship management. The award focuses not only on the software used but also on the way the company as a whole and its processes are geared to customers. BRITA won in the category "Introduction of CRM". The prize was awarded by a 6-man jury presided over by the editor-in-chief of acquisa, Christof Pause. Innovative sales concept At the 35th German Sales and Sales Manager Congress (DVVK), from 29 to 30 March 2012 in Munich, a prize for innovative sales concepts was awarded for the first time: the "acquisa Award". Here again, with its exemplary combination of e-shop and consumer loyalty system BRITA was one of the front runners, and came in second. This new accolade was established by the trade journal, acquisa, which is published by the Haufe Group, and is intended to honour companies that have developed modern sales concepts and thus successfully restructured their sales. HEALTHY Company 2013 In October 2013 the Wiesbaden Chamber of Commerce and Industry awarded BRITA GmbH a "Healthy Company" certificate. The certificate is aimed at companies of all sizes from Wiesbaden and the surrounding region for which their employees' health is or is scheduled to be of prime importance. The certificate is awarded in three stages: basic, premium and premium plus. The committee of experts honoured BRITA with the premium certificate, which is valid for two years. Until recertification BRITA intends to continue to devote a great deal of attention to implementing and improving its health management system. Investors in People In 2015, BRITA UK was assessed for the first time as one company in which it successfully retained the "Gold Standard IiP" (IiP = Investors in People). Having been awarded it for the first time in 2001, the company was able to successfully defend its status in 2006, 2009 and 2012 (previous awards were for BRITA Water Filter Systems Ltd., BWFS, and BRITA Manufacturing (UK) Ltd., BMC) in an evaluation procedure lasting several days. IiP is a recognized standard, assessing how a company's business success can be enhanced by means of the "people" factor, i.e., by motivating its staff. Our British subsidiary needed to prove its worth in ten assessment criteria, or "indicators", including in the following categories: Development of Managers, Development of Teams and Communications Efficiency within the Company. As few as 3% of the companies that use the "Investors in People" system (a total of 35,000 organizations in 50 countries) achieve "Gold Standard" status. In 2004, 2005, 2006 and 2008, BRITA Water Filter Systems Ltd., BRITA's sales company in the UK was included in the prestigious list of the "Sunday Times 100 Best Small Companies to Work For". This accolade is based on an assessment in eight categories: Leadership, My Manager, My Company, My Team, Personal Growth, Giving Something Back, Wellbeing and Fair Deal. In 2006, Best Companies Ltd. (the assessment and consultancy company that compiles the list) established an award that evaluates employees' commitment to their company. BRITA has been given a "two-star" rating here, thus being deemed "outstanding". TOP JOB In 2009 BRITA GmbH was awarded the TOP JOB seal of approval for the second time, (the first time was in 2005) for its impressive performance in the field of personnel management. The company was thus chosen as one of the top 100 employers amongst German small to medium-sized enterprises. Participating companies competed with comparable operations in terms of size and abilities in five disciplines: Management & Vision, Motivation & Dynamism, Culture & Communication, Staff Growth & Perspectives, Family & Social Orientation and Internal Entrepreneurship. Here, the main focus of interest is on "soft factors" such as independent responsibility, motivation, ability of staff members to work in teams, living out the company's corporate culture, and family-friendly policies. The comparisons between companies were largely based on an anonymous staff survey conducted by the University of St. Gallen. Entrepreneur of the Year – Finalist 2006 In 2006, Ernst & Young, one of the world's leading auditing and consultancy companies, honoured particular entrepreneurial achievements for the 10th time. Around 350 candidates entered the competition for the coveted title of "Entrepreneur of the Year". Alongside BRITA, just under 100 companies reached the final. What most impressed the jury about BRITA was its sustainable growth and its innovations. intermedia-globe Silver Award At the 2007 WorldMediaFestival in Hamburg, BRITA's corporate film "Waterology" received an "intermedia-globe Silver Award" in the category "Public Relations: Company Philosophy and Portrait". Independent specialist juries from Europe, Asia and North America had a total of 487 entries from 22 countries to evaluate. The festival presented awards to outstanding solutions using modern communication media. As well as assessing artistic and technical implementation, it primarily honoured those entries that were capable of using their message to successfully appeal to their target groups. "Waterology" succeeded in presenting all facets of the global company BRITA. And in doing this the film did not content itself with mere factual presentation, but derived its excitement and its entertainment value from the fascination with the element water. Robert Dyas BRITA UK was awarded 2nd most valuable supplier to UK national high street retailer Robert Dyas in 2015. BFA – Best Factory Awards In 2014, BRITA UK entered the Best Factory Awards and were successful in receiving the Judges Special Award as company to watch. Organized by Works Management in partnership with Cranfield School of Management, the Best Factory Awards (BFA) and Conference bring together the best manufacturers in the country to share best practice and to celebrate their achievements. The Cranfield School of Management is a top international business school whose reputation is founded on its ability to create, integrate and disseminate new management thinking. Its MBA, EMBA, Executive Education and Doctoral programmes are all ranked in the major league tablets.

Source: http://www.brita.be/medias/sys_brita/8454143471654096.pdf

Draft guidance for industry drug interaction studies — study design, data analysis, and implications for dosing and labeling

Guidance for Industry Drug Interaction Studies — Study Design, Data Analysis, and Implications for Dosing and Labeling DRAFT GUIDANCE This guidance document is being distributed for comment purposes only. Comments and suggestions regarding this draft document should be submitted within 60 days of publication in the Federal Register of the notice announcing the availability of the draft guidance. Submit comments to the Division of Dockets Management (HFA-305), Food and Drug Administration, 5630 Fishers Lane, rm. 1061, Rockville, MD 20852. All comments should be identified with the docket number listed in the notice of availability that publishes in the Federal Register. For questions regarding this draft document contact (CDER) Shiew-Mei Huang, 301-796-1541, or (CBER) Toni Stifano, 301-827-6190.

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3(1), April, 2012. ISSN: 2141- Printed in Nigeria. All rights reserved. © Global Research Publishing, 2012. Caffeine Content of Cocoa and Coffee Beverages in Lagos, Nigeria (pp. 404-411.) C. O. Ogah and O. T.obebe Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, Nigeria Correspondence Email