Marys Medicine


Effect of built environment on tsunami related injuries

Dinamithra NP et al AMJ 2013, 7 (1)
Open Access

Case Report
Clinical presentation and outcome of Sri-Lankan Ornamental
Tarantula Poecilotheria fasciata
spider bite: a case report
Dinamithra NP1*, Sivansuthan S1, Johnson P1,Nishshanka JGP1 1 Teaching Hospital Jaffna, Jaffna, Sri Lanka Abstract
We report on a 19-year-old boy with visible muscle spasms admitted to the hospitals 24 hours after spider bite. He was treated effectively with intravenous calcium gluconate followed by oral calcium supplements and made a full recovery 48 hours after the incident. Although no specific treatment exists in Srilanka, it has been suggested that calcium supplements may be beneficial to relieve the muscle spasms. Our patient made a full recovery with calcium supplements suggesting the treatment with calcium is beneficial in relieving the pain and muscle spasms caused by Sri-Lankan Ornamental Tarantula Poecilotheria fasciata. Key words: Sri Lankan Ornamental Tarantula; Poecilotheria fasciata; Venom
Copyright: 2013 Dinamithra NP et al. This is an open access article distributed under the
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. [email protected]
How to cite: Dinamithra N.P, Sivansuthan S, Johnson P,Nishshanka J.G.P. Clinical presentation and outcome of Sri-
Lankan Ornamental Tarantula Poecilotheria fasciata spider bite: a case report. Anuradhapura Medical Journal
Anuradhapura Medical Journal 2013 Volume 07 Issue 01 Page 10

Dinamithra NP et al AMJ 2013, 7 (1)
Open Access
Throughout history, envenoming by animal toxins has
fascinated humans. Animal toxins have made a vast
contribution to enhancing knowledge in human
physiology and pharmacology. Information on the nature
and mechanism of action of these toxins has enabled a
more scientific approach to the treatment of their
intoxications. Early and specific treatment is frequently
required after envenoming and often includes life support
and maintenance of vital functions by mechanical
ventilation, intra venous fluid and drug therapy. Spider
Figure 1 A. Visible muscle spasms (indicated by arrow),
bites are associated with a mortality of 1-17% in Chile, B. Disappearance of muscle spasms one hour after
Brazil(1), the Mediterranean region, Israel, North Africa intravenous calcium gluconate therapy
and some regions in the former Soviet Union. Most spiders have neuroactive substances in their venom(2), other systemic symptoms. He had taken 2 tablets (1 gram) which are characterized by different affinities by a series of paracetamol orally to relieve the pain. of different receptors and ionic neuronal channels(3). Twenty four hours after the incident he developed painful During the predation, spiders inject neurotoxins which are muscle spasms over right upper arm which made him to able to cause paralysis of their prey due to the blocking get admitted to the hospital. On admission he was in pain actions at the neuromuscular junctions and/or at the with visible muscle spasms over right tricep region, his central nervous system (CNS); generally the voltage- pulse rate was 40 beats / minute, respiratory rate 18 cycles gated sodium (Nav) and voltage-gated calcium (Cav) / minute, and blood pressure was 120/80 mmHg. He was channels constitute the most common targets of these treated with 1 gram of paracetamol and 4 miligram of toxins(3,4). Spider bites are mostly accidental and usually Chlopheniramine oraly . His symptoms were subsided they do not attack animals larger than themselves, some after 4hours of the onset (28 hours the bite). have aggressive behavior and will attack when After 4 hours (28 hours the bite) he again complained of approached by larger animals. Most spider bites on severe abdominal pain mainly over epigastric region humans are unintentional and happen when they press up where visible muscle spasms was obvious. (Figure 2 against spiders and receive a defensive bite. We report on A).Then he was treated with slow bolus of intravenous a 19-year-old boy with visible muscle spasms admitted to 10% calcium gluconate 10 milliliter over 10 minutes. He the hospitals 24 hours after spider bite. made a good recovery after 1hour followed by a few short lasting episodes of right triceps, right calf and rectus abdominis muscle spasms which were not as severe as the previous. On physical examination all the systems were normal except bradycardia of 40/minute revealed as a sinus bradycardia on 12 lead ECG. Blood investigations Alanine Transaminase(ALT)- 20, Asparate Transaminase (AST)- 29,WhiteBlood Count (WBC)-7000,Haemoblobin (Hb)-13gram/deciliter, (MCV) -86 Femto liter, Platelets -328,000/micro liter, Blood Urea 22milligram/deciliter, Serum Na-144, K-4.7, 9.10milligram/deciliter (8.10-10.40) with normal Urine Figure 2 Offending spider Sri-Lankan
Ornamental Tarantula Poecilotheria fasciata
After treatment (at 28 hours after the bite ) with single dose of intravenous Calcium gluconate and oral calcium Case presentation
lactate 300 milligram thrice daily , the patient improved A 19-year old boy from Karainagar (9° 44' 53.07"N 79° rapidly (Figure 2 B)and was discharged from hospital 52' 58.38"E) in Jaffna District admitted with right upper after 24 hours of admission (48 hours of the bite ) with arm pain and spasms of tricep muscle after 24 hours of a calcium lactate 300mg thrice daily for three days. spider bite to right foot. He was bitten by the spider at about 4 home garden while he was trying to take a Discussion
photograph of the spider. Offending spider was identified The clinical presentation and treatment modalities of by the experts with the help of the photographs brought Poecilotheria fasciata bite is not well documented in by the patient (Figure 1)(5,6). Just after the bite he noticed medical literature and there is no specific treatment for a severe pain at the site with local swelling without any Anuradhapura Medical Journal 2013 Volume 07 Issue 01 Page 11
Dinamithra NP et al AMJ 2013, 7 (1)
Open Access
that. Antivenoms are available for Latrodectus, Atrax and Signs and symptoms occurring within hours to 36 hours Loxosceles bites in many countries. These species are not post envenomation are typically abdominal pain, nausea, reported in Srilanka. Exact mechanisms of muscle spasms vomiting, fever, often > 39 to 40°C, myalgia and after Poecilotheria fasciata spider bite is yet to be artheralgias, headaches, fatigue, and weakness.Most identified. Pain and muscle spasms caused by spider bites spider bites are harmless, and require no specific are refractory to standard treatments but are relieved by treatment. Treatment of bites may depend on the type of intra venous calcium(7). Effectiveness of calcium spider; thus, capture of the spider—either alive, or in a gluconate is challenged in some studies[8]. Although well-preserved condition, is useful. calcium gluconate has been considered the first-line Treatment for non-poisonous spider bites include washing treatment of spider bite it is ineffective for pain relief the bite with soap and water and ice to reduce compared with a combination of intravenous opiods and inflammation (10). Analgesics and antihistamines may be benzodiazepines(8). Tarantula toxins inhibit activation of used, however antibiotics are not recommended unless voltage-activated potassium (Kv) channels by interacting there is also a bacterial infection present (10) There have with their voltage-sensing domains.They might cause the been reports of significant bites by Poecilotheria species, disturbance of skeletal muscle excitability responsible for occasionally resulting in hospitalization. Symptoms the tonic muscle spasms that have been described. include localized pain and swelling, exhaustion, moderate Possibly most relevant to our case of Poecilotheria to severe muscle cramping, labored breathing and fever, fasciata bite. It is postulated that the tonic spasms were sometimes delayed days after the initial bite. the result of a direct effect of venom neurotoxins acting on voltage-gated sodium and/or calcium channels in the Conclusion
victim's muscles(9). Our patient had a total plasma Ca2+ Although no specific treatment exists in Srilanka, it has concentration of 9.10milligram/deciliter (8.10-10.40) been suggested that calcium supplements may be after intravenous Calcium Gluconate which was towards beneficial to relieve the muscle spasms. Our patient made the lower end of the normal range, hinting that Ca2+ a full recovery with calcium supplements suggesting the might have entered the muscle fibres under the influence treatment with calcium is beneficial in relieving the pain of the putative spasm-producing toxin.Our patient had a and muscle spasms caused by Sri-Lankan Ornamental heart rate of around 40 beats per minute all throughout his Tarantula (Poecilotheria fasciata). hospital stay as well as two weeks review which we However, there is little documented clinical evidence of attributed to his normal heart rate. the effects of this (Poecilotheria fasciata ) spider bite in The clinical presentation depends on many variables, humans, so firm conclusions about the level of danger including the amount of venom injected. There is usually posed by this spider cannot be drawn. only one bite, which may cause cutaneous or systemic manifestation or both. Other organs may be involved, including the gastrointestinal system. The pancreas, renal, pulmonary, and cardiovascular systems are less commonly affected (10, 11). Competing Interests
Lucas S. Spider in Brazil. Toxicon 1988; 26: 759-72.
Hagiwara K, Sakai T, Miwa A, Kawai N, Nakajima T, Agelenin. A new neurotoxin from the venom of the spider.
Symposium on Peptide Chemistry 1991; 1: 351–56.
Glenn F, King GG. Modulation of insect CaV channels by peptidic spider toxins. Toxicon 2007; 49: 513–30.
King GF, Escoubas P, Nicholson GM. Peptide toxins that selectively target insect NaV and CaV channels. Channels
2008; 2: 100–16.
Ratnatilaka A. Medically Important Ants, Bees, Wasps and Spiders. Author Publication 2011; 1: 112-15.
Samarawickrama VAMPK, Janananda MDBG, Ranawana KB, Smith A. Study of the distribution of the genus
Poecilotheria of the family Theraposidae in Sri Lanka. Ceylon Journal of Science 2005; 34: 75–86.
Key GF. A comparison of calcium gluconate and methocarbamol in the treatment of Latrodectism. The American
journal of tropical medicine and hygiene
1981; 30: 273-77.
Clark RF, Wethern-Kestner S, Vance MV, Gerkin R. Clinical presentation and treatment of black widow spider
envenomation: a review of 163 cases. Annals of emergency medicine 1992; 21: 782-87.
Swartz KJ. Tarantula toxins interacting with voltage sensors in potassium channels. Toxicon 2007; 49: 213-30.
10. Hematology Basic Principles and Practice. 4th ed. Philadelphia: Churchill Livingtone 2005; 712–716. Anuradhapura Medical Journal 2013 Volume 07 Issue 01 Page 12

Dinamithra NP et al AMJ 2013, 7 (1)
Open Access
Submit your next Manuscript to
Medical Journal

Submit your manuscript at

Anuradhapura Medical Journal 2013 Volume 07 Issue 01 Page 12


Ch02_p 45.78

Modern Organocopper Chemistry. Edited by Norbert Krause Copyright > 2002 Wiley-VCH Verlag GmbH ISBNs: 3-527-29773-1 (Hardcover); 3-527-60008-6 (Electronic) 2Transmetalation Reactions Producing Organocopper Reagents Paul Knochel and Bodo Betzemeier Organocopper reagents constitute a key class of organometallic reagents, with nu-merous applications in organic synthesis [1]. Their high reactivities and chemo-selectivities have made them unique intermediates. Most reports use organocopperreagents of type 1 or 2, which are prepared from organolithiums. This trans-metalation procedure confers optimal reactivity, but in many cases it permitsonly the preparation of relatively unfunctionalized organocopper reagents. Morerecently, substantial developments have been taking place in transmetalations toorganocopper reagents starting from organometallic species that tolerate the pres-ence of functional groups [2], while synthetic methods permitting the preparationof functionalized organolithiums and organomagnesium compounds have alsobeen developed. All organometallics in which the metal M is less electronegativethan copper, and all organometallic species of similar electronegativity but withweaker carbon-metal bonds, are potential candidates for transmetalation reac-tions [3]. Thus, reaction conditions allowing the transmetalation of organo-boron,-aluminium, -zinc, -tin, -lead, -tellurium, -titanium, -manganese, -zirconium and-samarium compounds have all been found, resulting in a variety of new organo-copper reagents of type 3. Their reactivity is dependent on the nature of the origi-nal metal M, which in many cases is still intimately associated with the resultingorganocopper reagent (Scheme 2.1) [3–5].

Metabolic or drug induced: Haloperidol ORAL THRUSH: 500micrograms to 5mg oral nocte, ( ), OR: Good oral hygiene, and: Miconazole oral gel 24mg/ml Levomepromazine, oral or sc, from 6.25 mg od. qds treatment should be continued for 48hours after lesions have healed. Fluconazole 50mg daily Intestinal obstruction - contact Specialist Palliative