2014xx-3program-daily schedule.indd
RSA/ISBRA 2014 DAILY SCHEDULEFRIDAY, JUNE 20
FRIDAY, JUNE 20
5:00pm - 10:00pm RSA BOARD OF DIRECTORS MEETING - Closed
SATURDAY, JUNE 21
SATURDAY, JUNE 21
FETAL ALCOHOL SPECTRUM DISORDER - STUDY GROUP
Integrative Neurosciences Initiative on Alcoholism (INIA) - STRESS – closed
Integrative Neurosciences Initiative on Alcoholism (INIA) - WEST – closed
Interventional and Feeding Studies of Alcohol: Issues in Designing a Clinical Trial – open 6th Annual Dr. Charles S. Lieber Satellite: Alcohol and Organ Damage – open Effective Preparation of Slide Presentations and Manuscripts: Things You Need to Know - open 6th Meeting of the Alcohol Hangover Research Group - open Liver and Alcohol Genomic - open Metabolic Reprogramming and Cell Fate Regulation in Alcohol-Associated Diseases - open GRAND C 10th Annual Mechanisms of Behavior Change - The New Scientifi c Agenda: The Continuum of Mechanism Development - open RSA BOARD OF DIRECTORS MEETING - Closed
RSA/ISBRA REGISTRATION DESK - Open
2014 RSA/ISBRA OPENING RECEPTION - LITE FARE
SUNDAY, JUNE 22
SUNDAY, JUNE 22
CONTINENTAL BREAKFAST - Nametag Required
RSA/ISBRA REGISTRATION DESK - Open
OFFICIAL
Dr. Laura Nagy - RSA President's Remarks Dr. Edward Riley - ISBRA President's Remarks Dr. George Koob - NIAAA Director PLENARY SESSION I - DR. TING-KAI LI LECTURESHIP
WHAT WORKS FOR TED MAY NOT WORK FOR ED – ABOUT BIOLOGY AND TREATMENT RESPONSE IN ALCOHOLISM
Karl Mann, M.D., Ph.D., Chair of the Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany Karl Mann received his MD from Mainz University and his PhD from Tuebingen University. He is a board certifi ed neurologist and psychiatrist, psy-chotherapist. During his studies he trained at Dartmouth Medical School and at St. Anne Hospital in Paris. He was appointed chair in addiction research at the Central Institute of Mental Health in Mannheim, University of Heidelberg in 1999. He is interested in the biological basis of addictive behavior in order to improve treatment approaches in alcoholism, smoking and gambling. He received several prizes and currently serves on the WHO board for the diagnosis of addictions in ICD 11. Effect sizes from alcohol treatment trials are modest. The heterogeneity of patients may be one reason. In our Predict study (Mann et al 2009; 2013) we used biological measures such as genotyping and brain imaging (fMRI, receptor PET) to phenotype patients. We hypothesized that patients, for whom alcohol acts as positive reinforcer could be separated from those for whom it is a negative reinforcer. The former were expected to be naltrexone responders, the latter to respond better to acamprosate. Results in 426 patients will be presented. Genetics, fMRI and some psycho-metric tests are supportive of our basic predictions. Another approach to broaden treatment options concerns the choice of treatment goals. The European Medicines Agency (EMA 2010) has opened the door for testing a reduction of alcohol consumption. Three trials with the opioid modulator nalmefene were performed (i.e. Mann et al 2013). They offer an additional option for some of the Teds and Eds, who do perceive the need to cut down on their drinking, but are not ready to abstain from alcohol. ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
SUNDAY, JUNE 22
SUNDAY, JUNE 22
9:45am - 10:15am COFFEE BREAK
10:15am - 12:15pm SYMPOSIUM
CHILDHOOD ADVERSITY AND RISKY DRINKING FROM MIDDLE SCHOOL TO MIDDLE AGE
Organizers/Chairs: Mary Waldron Dept. of Counseling & Education Psychology, Indiana Univ., Bloomington, IN
and Carolyn Sartor, Dept. of Psychiatry, Yale Univ. School of Medicine, New Haven, CT
10:15 INTRODUCTION Andrew Heath, Dept. of Psychiatry, Washington Univ. School of Medicine, St. Louis, MO UNDERSTANDING THE ASSOCIATION BETWEEN EARLY LIFE EVENTS AND PERCEIVED STRESS IN PREDICTING INITIATION OF ALCOHOL USE IN A MIDDLE-SCHOOL SAMPLE Kristina Jackson, Dept. of Behavioral and Social Sciences, Brown School of Public Health, Providence, RI EARLY ALCOHOL INVOLVEMENT AND RISKS FROM PARENTAL ALCOHOLISM AND PARENTAL SEPARATION Mary Waldron Dept. of Counseling & Education Psychology, Indiana Univ., Bloomington, IN MODERATION OF ADH1B GENETIC VARIANTS BY CHILDHOOD ADVERSITY ON RISK FOR PROBLEM DRINKING Carolyn Sartor, Dept. of Psychiatry, Yale Univ. School of Medicine, New Haven, CT POLYGENIC SCORES PREDICT ALCOHOL PROBLEMS IN AN INDEPENDENT SAMPLE AND SHOW MODERATION BY PARENTAL MONITORING Jessica Salvatore, Virginia Inst. For Psychiatric and Behavioral Genetics, Virginia Commonwealth Univ., Richmond, VA Andrea Hussong, Dept. of Psychology, Univ. of North Carolina-Chapel Hill, Chapel Hill, NC 10:15am - 12:15pm SYMPOSIUM
ACTIVE TREATMENT INGREDIENTS AND CLIENT MECHANISMS OF CHANGE IN BEHAVIORAL
TREATMENTS FOR ALCOHOL USE DISORDERS: PROGRESS TEN YEARS LATER
Organizers/Chairs: Richard Longabaugh, Brown Univ., Center for Alcohol and Addiction Studies, Providence, RI
and Molly Magill, Brown Univ., Center for Alcohol and Addiction Studies, Providence, RI
10:15 INTRODUCTION Molly Magill, Brown Univ., Center for Alcohol and Addiction Studies, Providence, RI EXAMINING THE PRIMARY MODEL OF CAUSAL PROCESS IN MOTIVATIONAL INTERVIEWING WITH ALCOHOL USE AND OTHER ADDICTIVE BEHAVIORS Molly Magill, Brown Univ., Center for Alcohol and Addiction Studies, Providence, RI CBT INGREDIENTS AND MECHANISMS IN AUD/SUD: WHAT WE'VE LEARNED IN THE PAST 10 YEARS AND WHAT'S STILL MISSING Brian Kiluk, Dept. of Psychiatry, Yale Univ., New Haven, CT ALCOHOL BEHAVIORAL COUPLE THERAPY: ACTIVE INGREDIENTS AND MECHANISMS OF BEHAVIOR CHANGE Barbara McCrady, Center on Alcoholism, Substance Abuse and Addiction, Univ. of New Mexico, Albuquerque, NM IMPROVING 12-STEP TREATMENT BY UNDERSTANDING AA BETTER J. Scott Tonigan, Center on Alcoholism, Substance Abuse and Addiction, Univ. of New Mexico, Albuquerque, NM Richard Longabaugh, Brown Univ., Center for Alcohol and Addiction Studies, Providence, RI ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
SUNDAY, JUNE 22
SUNDAY, JUNE 22
10:15am - 12:15pm SYMPOSIUM
FROM CELLULAR TO GENOMIC AND EPIGENOMICS TO IDENTIFY THERAPEUTIC TARGETS FOR ALCOHOLISM
Organizers/Chairs: Subhash C. Pandey, Dept. of Psychiatry, Univ. of Illinois and Jesse Brown VAMC, Chicago, IL
and Feng C. Zhou, Dept. of Anatomy and Cell Biology, Indiana Univ. Sch. Med, Indianapolis, IN
10:15 INTRODUCTION Antonio Noronha, Div. of Neuroscience and Behavior, NIAAA/NIH, Bethesda, MD ROLE OF EPIGENETIC CHANGES PRODUCED BY ETHANOL EXPOSURE IN ANXIETY AND ALCOHOLISM Subhash C. Pandey, Dept. of Psychiatry, Univ. of Illinois and Jesse Brown VAMC, Chicago, IL REDUCTION OF EXCESSIVE ALCOHOL INTAKE AND RELAPSE BY SELECTIVE INHIBITION OF HDAC1 Mickael Naassila, Research Group on Alcohol & Pharmacodependence, Univ. of Picardie Jules Verne, Amiens, France ALCOHOL ALTERS THE EPIGENETIC PROGRAM AND DYNAMICS OF DEVELOPING BRAIN Feng C. Zhou, Dept. of Anatomy and Cell Biology, Indiana Univ. Sch. Med., Indianapolis, IN TRANSGENERATIONAL EPIGENETIC EFFECTS OF FETAL ALCOHOL EXPOSURE ON THE NEUROENDOCRINE-IMMUNE AXIS Dipak Sarkar, Endocrinology Program, Dept. of Animal Sciences, Rutgers Univ., New Brunswick, NJ Fulton Crews, Bowels Center for Alcohol Studies, Univ. of North Carolina, Chapel Hill, NC 10:15am - 12:15pm SYMPOSIUM
NEW TRICKS FROM AN OLD PEPTIDE: NOVEL ROLES FOR NPY IN ALCOHOL USE DISORDERS AND ANXIETY
Organizer/Chair: Kristen Pleil, Bowles Center for Alcohol Studies and Dept. of Pharmacology,
UNC School of Medicine, Chapel Hill, NC
10:15 INTRODUCTION Kristen Pleil, Bowles Center for Alcohol Studies and Dept. of Pharmacology, UNC School of Medicine, Chapel Hill, NC GENETIC AND EPIGENETIC MECHANISMS ON NPY, STRESS RESPONSE AND ALCOHOL USE DISORDER Ke Xu, Dept. of Psychiatry, Yale School of Medicine, West Haven, CT EPIGENETIC REGULATION OF NEUROPEPTIDE Y GENE EXPRESSION CONTRIBUTES TO ANXIETY-LIKE AND ALCOHOL- Amul Sakharkar, Dept. of Psychiatry, Univ. of Illinois and Jesse Brown VAMC, Chicago, IL NPY SIGNALING INHIBITS EXTENDED AMYGDALA CRF NEURONS TO SUPPRESS BINGE ALCOHOL DRINKING Kristen Pleil, Bowles Center for Alcohol Studies and Dept. of Pharmacology, UNC School of Medicine, Chapel Hill, NC A NOVEL, BRAIN PENETRANT NPY-Y2R ANTAGONIST IN ANIMAL MODELS OF ALCOHOL-INTAKE AND ANXIETY Annika Thorsell, Dept. of Clinical and Experimental Medicine, Linkoping Univ., Linkoping, Ostergotland, Sweden Markus Heilig, LCTS, NIAAA/NIH, Bethesda, MD ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
SUNDAY, JUNE 22
SUNDAY, JUNE 22
10:15am - 12:15pm SYMPOSIUM
***ALCOHOL AND THE ADOLESCENT BRAIN: INTEGRATING HUMAN AND ANIMAL RESEARCH
Organizers/Chairs: Joanna Jacobus, Dept. of Psychiatry, Univ. of California-San Diego, San Diego, CA
and Lindsay Squeglia, Dept. of Psychiatry, Univ. of California-San Diego, San Diego, CA
10:15 INTRODUCTION Susan Tapert, Dept. of Psychiatry, VA San Diego Healthcare System, Univ. of California-San Diego, San Diego, CA EFFECT OF ADOLESCENT BINGE-LIKE ALCOHOL EXPOSURE ON THE COGNITIVE FUNCTION OF THE ADULT PFC: FINDINGS FROM THE NADIA CONSORTIUM L. Judson Chandler, Dept. of Neurosciences and Psychiatry, Medical Univ. of South Carolina, Charleston, SC RSA MEMORIAL AWARDEE - ADOLESCENT BINGE ETHANOL EXPOSURE ALTERS ADULT CORTICAL NEUROBIOLOGY: CONTRIBUTIONS TO COGNITIVE FLEXIBILITY IN ADULTHOOD Ryan Vetreno, Bowles Center for Alcohol Studies, Univ. of North Carolina School of Medicine, Chapel Hill, NC NEURAL VULNERABILITIES IN FAMILY HISTORY POSITIVE YOUTH Lindsay Squeglia, Dept. of Psychiatry, Univ. of California-San Diego, San Diego, CA RSA MEMORIAL AWARDEE - CORTICAL THICKNESS AND NEUROCOGNITION IN ADOLESCENT ALCOHOL AND MARIJUANA USERS FOLLOWING 28 DAYS OF MONITORED ABSTINENCE Joanna Jacobus, Dept. of Psychiatry, Univ. of California-San Diego, San Diego, CA Edith Sullivan, Dept. of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford, CA 10:15am - 12:15pm SYMPOSIUM
***ALCOHOL AND TRAUMA: IMMUNOLOGIC CONSEQUENCES
Organizers/Chairs: Elizabeth J. Kovacs, Dept. of Surgery, Loyola Univ. Chicago, Stritch School of Medicine, Maywood, IL
and Patricia E. Molina, Dept. of Physiology, Louisiana State Univ. HSC, New Orleans, LA
10:15 INTRODUCTION Elizabeth Kovacs, Dept. of Surgery, Loyola Univ. Chicago, Stritch School of Medicine, Maywood, IL THE EVALUATION AND ASSOCIATION OF BLOOD ALCOHOL CONTENT AND INJURY SEVERITY WITH IN-HOSPITAL DEATH AT A STATEWIDE REFERRAL TRAUMA CENTER Majid Afshar, Div. of Pulmonary and Critical Care Medicine, Univ. of Maryland School of Medicine, Baltimore, MD MODULATION OF INFLAMMATION AFTER HEMORRHAGE/RESUSCITATION - EFFECTS OF ETHANOL AND ETHYL PYRUVATE IN VIVO AND IN VITRO Mark Lehnert, Trauma-, Hand- and Reconstructive Surgery, Univ. Hospital Frankfurt, Goethe Univ., Frankfurt, Germany ALCOHOL ABUSE AND TRAUMATIC BRAIN INJURY: NEUROIMMUNOMODULATORY SYNERGY Patricia Molina, Dept. of Physiology, Louisiana State Univ. HSC, New Orleans, LA ETHANOL EXACERBATION OF CARDIAC INJURY Jason Gardner, Dept. of Physiology, Louisiana State Univ. HSC, New Orleans, LA Mashkoor Choudhry, Dept. of Surgery, Loyola Univ. Chicago, Stritch School of Medicine, Maywood, IL ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
SUNDAY, JUNE 22
SUNDAY, JUNE 22
10:15am - 12:15pm SYMPOSIUM
ALCOHOL AND THE CONNECTOME: FUNCTIONAL CONNECTIVITY APPROACHES TO
UNDERSTANDING THE DEVELOPMENT AND PROGRESSION OF ALCOHOLISM
Organizer/Chair: Joseph Schacht, Dept. of Psychiatry & Behavioral Sciences,
Medical Univ. of South Carolina, Charleston, SC
10:15 INTRODUCTION Joseph Schacht, Dept. of Psychiatry & Behavioral Sciences, Medical Univ. of South Carolina, Charleston, SC IS BRAIN CONNECTIVITY A PREDICTOR OF DRUG USE? INSIGHTS FROM A LONGITUDINAL STUDY OF ADOLESCENCE Hugh Garavan, Dept. of Psychiatry, Univ. of Vermont, Burlington, VT FUNCTIONAL CONNECTIVITY DURING RESPONSE INHIBITION AND ALCOHOL CUES PROCESSING IN ALCOHOLISM Lara Ray, Dept. of Psychology, Univ. of California, Los Angeles, CA PREDICTION AND VALIDATION OF ALCOHOL DEPENDENCE SEVERITY FROM NEURAL FUNCTIONAL CONNECTIVITY DURING ALCOHOL CUE EXPOSURE Joseph Schacht, Dept. of Psychiatry & Behavioral Sciences, Medical Univ. of South Carolina, Charleston, SC STRUCTURAL AND FUNCTIONAL BRAIN CONNECTIVITY IN RECENTLY DETOXIFIED ALCOHOL-DEPENDENT PATIENTS Sabine Vollstädt-Klein, Central Inst. of Mental Health, Heidelberg Univ., Mannheim, Germany Bonnie Nagel, Depts. Of Psychiatry and Behavioral Neuroscience, Oregon Health & Science Univ., Portland, OR 10:15am - 12:15pm SYMPOSIUM
ISBRA (International Society for Biomedical Research on Alcoholism)/
APSAAR (Asia-Pacifi c Society for Alcohol and Addiction Research) JOINT SYMPOSIUM:
PHARMACOTHERAPY OF ALCOHOL USE DISORDERS: INTERNATIONAL PERSPECTIVES
Organizers/Chairs: Susumu Higuchi, National Hospital, Kurihama Medical and Addiction Center, Kanagawa, Japan
and Robert Swift, Providence VAMC and Brown Univ. Alpert Medical School, Providence, RI
10:15 INTRODUCTION Susumu Higuchi, National Hospital, Kurihama Medical and Addiction Center, Kanagawa, Japan ASSESSMENT REACTIVITY IN PHARMACOTHERAPY CLINICAL TRIALS: ACAMPROSATE TREATMENT EFFECT SIZE IS NEGATIVELY RELATED TO AMOUNT OF ASSESSMENT Robert Swift, Providence VAMC and Brown Univ. Alpert Medical School, Providence, RI EFFICACY OF ACAMPROSATE FOR THE TREATMENT OF ALCOHOL DEPENDENCE LONG AFTER RECOVERY FROM WITHDRAWAL SYNDROME: AN RCT CONDECTED IN JAPAN Susumu Higuchi, National Hospital, Kurihama Medical and Addiction Center, Kanagawa, Japan EFFICACY OF DISULFIRAM FOR THE TREATMENT OF ALCOHOL DEPENDENCE ASSESSED WITH A MULTI-CENTER RANDOMIZED CONTROLLED TRIAL Atsushi Yoshimura, National Hospital, Kurihama Medical and Addiction Center, Kanagawa, Japan A PHARMACOGENETIC STUDY OF NALTREXONE IN KOREAN ALCOHOLICS Sung-Gon Kim, Pusan National Univ. School of Medicine, Yangsan-si Gyeongnam, Republic of Korea Karl Mann, Central Institute of Mental Health, Univ. of Heidelberg, Mannheim, Germany ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
SUNDAY, JUNE 22
SUNDAY, JUNE 22
12:20pm - 1:50pm Fetal Alcohol Canadian Expertise (FACE): Update on Canadian Research in Fetal Alcohol Spectrum Disorder 12:20pm - 1:50pm SOCIAL WORKERS LUNCH - Closed Organized by Michie Hesselbrock 12:20pm - 1:50pm RSA SPONSORED STUDENT LUNCH
Organized by the RSA Education Committee Chairs: Sandra Mooney and Lisa Popp 12:20pm - 1:50pm ISBRA BOARD OF DIRECTORS MEETING
OPEN TO 2010-2014 BOARD MEMBERS International Society for Biomedical Research on Alcoholism Board Meeting and Lunch SYMPOSIUM
PARENTAL INFLUENCE ON ADOLESCENT USE BEHAVIOR:
CROSS NATIONAL FINDINGS & IMPLICATIONS FOR INTERVENTION
Organizers/Chairs: Kristen G. Anderson, Dept. of Psychology, Reed College, Portland, OR
and Sarah Feldstein Ewing, Center on Alcoholism, Substance Abuse and Addictions,
Univ. of New Mexico, Albuquerque, NM
2:00 INTRODUCTION Kristen Anderson, Dept. of Psychology, Reed College, Portland, OR INFLUENCE OF PARENTAL BEHAVIOR AND ATTITUDES ON ADOLESCENT DRINKING MOTIVES AND ALCOHOL USE: A Benjamin Ladd, Adolescent Health Research Program, Reed College, Portland, OR EVERYBODY ELSE IS DOING IT? NORM PERCEPTIONS ABOUT THE SUPPLY OF ALCOHOL AMONG PARENTS OF ADOLESCENTS Conor Gilligan, School of Medicine and Public Health, Univ. of Newcastle, Callaghan, NSW, Australia WHY PARENTS MAY BE PARTICULARLY IMPORTANT: EVALUATING TREATMENT OUTCOMES BY CULTURE WITH HISPANIC YOUTH Sarah Feldstein Ewing, Center on Alcoholism, Substance Abuse and Addictions, Univ. of New Mexico, Albuquerque, NM EFFECTS OF AN ALCOHOL PREVENTION PROGRAM TARGETING STUDENTS AND/OR PARENTS: TESTING THE GATEWAY Ina Koning, Utrecht Univ., Utrecht, The Netherlands Seth Schwartz, Dept. of Epidemiology and Public Health, Univ. of Miami, Miami, FL ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
SUNDAY, JUNE 22
SUNDAY, JUNE 22
SYMPOSIUM
NOVEL APPROACHES TO STUDYING ALCOHOL USE AND DEPENDENCE
Organizer/Chair: Kasey Creswell, Carnegie Mellon Univ., Pittsburgh, PA
Organizer: John Curtin, Dept. of Psychology, Univ. of Wisconsin, Madison, WI
2:00 INTRODUCTION Kasey Creswell, Carnegie Mellon Univ., Pittsburgh, PA A DYNAMIC MULTIMODAL EXAMINATION OF THE EFFECTS OF ALCOHOL ON EMOTION AND SOCIAL BONDING Michael Sayette, Dept. of Psychology and Psychiatry, Univ. of Pittsburgh, Pittsburgh, PA INDIVIDUAL DIFFERENCES IN SENSITIVITY TO THE REWARDING SOCIAL EFFECTS OF ALCOHOL Kasey Creswell, Carnegie Mellon Univ., Pittsburgh, PA STRESS NEUROADAPTATION IN ADDICTION: INSIGHTS FROM LABORATORY DRUG ADMINISTRATION AND DEPRIVATION John Curtin, Dept. of Psychology, Univ. of Wisconsin, Madison, WI EMERGING PARADIGMS IN ALCOHOL BIOBEHAVIORAL SCIENCE Mark Goldman, Dept. of Psychology and Psychiatry, Univ. of South Florida, Tampa, FL Kenneth Sher, Dept. of Psychology, Univ. of Missouri, Columbia, MO SYMPOSIUM
THE ACETALDEHYDE PARADOX: AVERSIVE IN THE PERIPHERY BUT REINFORCING IN THE BRAIN
Organizer/Chair: Yedy Israel, Univ. of Chile, ICBM Pharmacology Program, Santiago, Chile
2:00 INTRODUCTION Yedy Israel, Univ. of Chile, ICBM Pharmacology Program, Santiago, Chile THE REINFORCING EFFECTS OF THE ACTIVE METABOLITES OF ALCOHOL: THE ROLE OF THE MESOLIMBIC Gerard Deehan, Jr., Univ. of Indiana School of Medicine, Inst. for Psychiatric Research, Indianapolis, IN ACETALDEHYDE INDUCES ANXIOLYSIS OR ANXIOGENESIS DEPENDING ON THE ROUTE OF ADMINISTRATION Merce Correa, Univ. Juame I, Dept. de Psicobiologia, Castello, Spain A CLEAR PARADOX: AVERSIVE EFFECTS OF LIVER-GENERATED ACETALDEHYDE BUT REWARDING/REINFORCING EFFECTS OF ACETALDEHYDE GENERATED IN THE BRAIN. Yedy Israel, Univ. of Chile, ICBM Pharmacology Program, Santiago, Chile ACETALDEHYDE AND THE NON METABOLIZED-FRACTION OF ETHANOL: SIMULTANEOUS AND OPPOSITE ACTIONS IN THE VENTRAL TEGMENTAL AREA DOPAMINE NEURONS Ana Polache, Dept. de Farmacia I Technologia Farmaceutica, Univ. of Valencia, Burjassot, Valencia, Spain Merce Correa, Univ. Juame I, Dept. de Psicobiologia, Castello, Spain ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
SUNDAY, JUNE 22
SUNDAY, JUNE 22
SYMPOSIUM
PUBERTY, GONADAL HORMONES, AND SEX DIFFERENCES IN ALCOHOL ABUSE AND DEPENDENCE
Organizer/Chair: Ellen Witt, Div. of Neuroscience and Behavior, NIAAA/NIH, Bethesda, MD
Chair: Linda Spear, Dept. of Psychology, Binghamton Univ., Binghamton, NY
2:00 INTRODUCTION Ellen Witt, Div. of Neuroscience and Behavior, NIAAA/NIH, Bethesda, MD IMPACT OF GONADAL HORMONES ON ETHANOL INTAKE AND SENSITIVITIES Linda Spear, Dept. of Psychology, Binghamton Univ., Binghamton, NY PUBERTY AND ETHANOL CONSUMPTION AND DEPENDENCE IN RODENTS Cynthia Kuhn, Dept. of Pharmacology and Cancer Biology, Duke Univ. School of Medicine, Durham, NC ETHANOL AND STEROID HORMONES INDUCE CONDITIONED SOCIAL PREFERENCE IN MICE Ruth Wood, Keck School of Medicine, Univ. of Southern California, Los Angeles, CA SEXUALLY DIMORPHIC CONSEQUENCES OF ADOLESCENT BINGE ALCOHOL EXPOSURE Magdalena Przybycien-Szymanska, Neurological Surgery, Loyola Univ. Medical Center, Maywood, IL Joanne Weinberg, Dept. of Cellular and Physiological Sciences, Univ. of British Columbia, Vancouver, BC, Canada SYMPOSIUM
***BIDIRECTIONAL INTERACTIONS BETWEEN ALCOHOL, DRUGS AND SOCIAL ENVIRONMENT
IN HUMANS AND VOLES: SOCIALLY MONOGAMOUS SPECIES COMPARED
Organizer/Chair: Andrey Ryabinin, Dept. of Behavioral Neuroscience, Oregon Health & Science Univ., Portland, OR
Chair: Kenneth Leonard, Research Inst. On Addictions and Univ. of Buffalo, Buffalo, NY
2:00 INTRODUCTION Andrey Ryabinin, Dept. of Behavioral Neuroscience, Oregon Health & Science Univ., Portland, OR THE EFFECT OF SOCIAL INFLUENCE ON DECISION-MAKING IN YOUNG ADULTS USING ALCOHOL AND MARIJUANA: Jodi Gilman, Center for Addiction Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA MODELING SOCIAL INFLUENCES ON ALCOHOL DRINKING, RELAPSE, AND NALTREXONE TREATMENT OUTCOMES IN THE PRAIRIE VOLE Caroline Hostetler, Dept. of Behavioral Neuroscience, Oregon Health & Science Univ., Portland, OR ALCOHOL USE AND INTIMATE PARTNER VIOLENCE DURING THE TRANSITION TO PARENTHOOD Erica Woodin, Dept. of Psychology, Univ. of Victoria, Victoria, BC, Canada THE BIOLOGY OF "THE MORNING AFTER": ALCOHOL AFFECTS SOCIAL BONDING DIFFERENTLY IN MALE AND FEMALE PRAIRIE VOLES Allison Anacker, Smith College, Clark Science Center, Northampton, MA Kenneth Leonard, Research Inst. On Addictions and Univ. of Buffalo, Buffalo, NY ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
SUNDAY, JUNE 22
SUNDAY, JUNE 22
SYMPOSIUM
***STABILIZATION OF THE DOPAMINE SYSTEM AS A POTENTIAL TREATMENT
STRATEGY FOR ALCOHOL USE DISORDERS - ANIMAL AND HUMAN STUDIES
Organizer/Chair: Pia Steensland, Dept. of Clinical Neuroscience, Karolinska Inst., Stockholm, Sweden
Chair: Anna Goudriaan, Dept. of Psychiatry, Univ. of Amsterdam, Amsterdam, The Netherlands
2:00 INTRODUCTION Pia Steensland, Dept. of Clinical Neuroscience, Karolinska Inst., Stockholm, Sweden MODAFINIL: EFFECTS ON ALCOHOL DEPENDENCE IN A CLINICAL TRIAL AND RELATION WITH IMPULSIVITY AND OTHER Anna Goudriaan, Dept. of Psychiatry, Univ. of Amsterdam, Amsterdam, The Netherlands THE DOPAMINE D2 RECEPTOR PARTIAL AGONIST ARIPIPRAZOLE REDUCES ESCALATED ALCOHOL SELF-ADMINISTRATION IN DEPENDENT MICE Howard Becker, Charleston Alcohol Research Center, Medical Univ. of South Carolina, Charleston, SC CLINICAL STUDIES WITH ARIPIPRAZOLE FOR ALCOHOL DEPENDENCE: POSSIBLE ROLE OF IMPULSIVITY? Raymond Anton, Charleston Alcohol Research Center, Medical Univ. of South Carolina, Charleston, SC EVALUATION OF THE MONOAMINE STABILIZER (-)-OSU6162 AS A POTENTIAL NOVEL TREATMENT OF ALCOHOL USE DISORDERS - FROM BENCH TO CLINIC Nitya Jayaram-Lindstrom, Dept. of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Jorgen Engel, Dept. of Pharmacology, Univ. of Gothenburg, Gothenburg, Sweden SYMPOSIUM
SOCIALLY BASED BRIEF INTERVENTIONS FOR ADOLESCENTS AND
EMERGING ADULTS: OUTCOMES AND MECHANISMS OF CHANGE
Organizer/Chair: Christianne Esposito-Smythers, Dept. of Psychology, George Mason Univ., Fairfax, VA
2:00 INTRODUCTION Christianne Esposito-Smythers, Dept. of Psychology, George Mason Univ., Fairfax, VA EXAMINING THE EFFICACY OF A BRIEF PARENT-BASED INTERVENTION FOR ADOLESCENT DRINKERS AND THEIR SIBLINGS Lynn Hernandez, Dept. of Behavioral & Social Sciences, Brown Univ. Ctr. for Alcohol & Addiction Studies, Providence, RI ALCOHOL, SUICIDE, HIV PREVENTION FOR TEENS IN MENTAL HEALTH TREATMENT: PRELIMINARY RESULTS OF A CLINICAL TRIAL Christianne Esposito-Smythers, Dept. of Psychology, George Mason Univ., Fairfax, VA SOCIAL COMPARISON AS AN ALTERNATIVE MECHANISM OF PNF EFFICACY Clayton Neighbors, Dept. of Psychology, Univ. of Houston, Houston, TX INFLUENCES OF PEER DESCRIPTIVE NORMS ON BEHAVIOR CHANGE IN COLLEGE DRINKING INTERVENTIONS: PROXIMAL AND DISTAL MEDIATIONAL EFFECTS Allecia Reid, Dept. of Psychology, Colby College, Waterville, ME James Murphy, Dept. of Psychology, Univ. of Memphis, Memphis, TN ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
SUNDAY, JUNE 22
SUNDAY, JUNE 22
SYMPOSIUM
ALCOHOL AND INTERACTION WITH DRUGS, XENOBIOTICS AND CARCINOGENS (ESBRA/ISBRA JOINT SESSION)
Organizer: Helmut Seitz, Alcohol Research Dept., Univ. of Heidelberg, Heidelberg, Germany
Chair: Edward Riley, Center for Behavioral Teratology, San Diego State Univ., San Diego, CA
2:00 INTRODUCTION Samir Zakhari, Distilled Spirits Council of the United States, Washington, DC ALCOHOL AND DRUG INTERACTION: ROLE OF CYTOCHROME P4502E1 Tomas Zima, Dept. of Biochemistry, First Medical Faculty Charles Univ., Prague, Czech Republic DRUGS AND ALCOHOLIC LIVER DISEASE: IS LIVER STIFFNESS A NOVEL TOOL TO ESTIMATE PHARMACOKINETICS? Sebastian Mueller, Dept. of Medicine and Ctr. for Alcohol Research, Univ. of Heidelberg, Heidelberg, Germany ALCOHOL INTERACTIONS WITH DRUG OF USE A THERAPEUTIC MISADVENTURE Manuela Neuman, In Vitro Drug Safety and Biotechnology, Univ. of Toronto, Toronto, Ontario, Canada THE INTERACTIONS BETWEEN ALCOHOL AND CAROTENOIDS/VITAMIN A METABOLISM: IMPLICATIONS FOR ALCOHOLIC LIVER DISEASE PREVENTION Xiang-Dong Wang, Nutrition and Cancer Biology Lab., Tufts Univ., Boston, MA Samuel French, Harbor UCLA Medical Ctr., Torrance, CA POSTER SESSION I
POSTER NUMBERS: 1-292 / ABSTRACT NUMBERS: 1-292
two 1-hour manning periods - Number 1 fi rst hour; number 2 second hour, fi nal 30 minutes unmanned period (light refreshments) PAPER SESSION
ENOCH GORDIS AWARD FINALISTS - STUDENTS
MODERATOR: Graeme Mason
Mason INTRODUCTION THE SPECIFICITY OF AN ALCOHOL HABIT: NEURONAL ENCODING IN DORSAL STRIATUM DURING HABITUAL DRINKING AND ITS DEPENDENCE ON DOPAMINE TRANSMISSION INTEGRATING EXTERNALIZING AND INTERNALIZING PATHWAYS TO PROBLEM DRINKING ACROSS ASSOCIATION OF ALCOHOL DRINKING WITH SERUM BILIRUBIN, AN ENDOGENOUS ANTIOXIDANT: DIETARY NUTRIENT INTAKE IS ASSOCIATED WITH HYPERACTIVITY AMONG CHILDREN WITH PRENATAL HEPATIC GLYCOGEN METABOLISM IS IMPAIRED BY ALCOHOL CONSUMPTION: POSSIBLE ROLE OF THE LIVER MOLECULAR CLOCK THE EFFECT OF CHRONIC INTRACEREBROVENTRICULAR (ICV) MONOCYTE CHEMOTACTIC PROTEIN -1 (MCP-1) ON ETHANOL SELF-ADMINISTRATION ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
SUNDAY, JUNE 22
SUNDAY, JUNE 22
***ARE THERE NEW APPROACHES TO THE GENETICS OF ALCOHOLISM - OR WHY BOTHER
Organizer/Chair: Michael Miles, Dept. of Pharmacology & Toxicology, Virginia Commonwealth Univ., Richmond, VA
6:30 INTRODUCTION Michael Miles, Dept. of Pharmacology & Toxicology, Virginia Commonwealth Univ., Richmond, VA PHENOME-WIDE ASSOCIATION: NEW OPPORTUNITIES AND NEW PROBLEMS Robert Williams, Dept. of Anatomy and Neurobiology, Univ. of Tennessee HSC, Memphis, TN HOW BEST MIGHT WE EMPLOY LABORATORY ANIMALS? John Crabbe, Portland Alcohol Research Center, VA Medical Center and Oregon Health & Science Univ., Portland, OR USING CROSS-SPECIES VALIDATED GENE NETWORKS IN ANIMAL MODELS TO DEFINE NEUROBIOLOGICAL MECHANISMS AND TREATMENT STRATEGIES FOR ALCOHOLISM Michael Miles, Dept. of Pharmacology & Toxicology, Virginia Commonwealth Univ., Richmond, VA GENOMEWIDE ASSOCIATION STUDY OF ALCOHOL QUANTITATIVE TRAITS IN AN IRISH SAMPLE SUPPORTS THE USE OF PHENOTYPES BEYOND ALCOHOL DEPENDENCE DIAGNOSIS Brien Riley, Dept. of Psychiatry, Virginia Commonwealth Univ., Richmond, VA Danielle Dick, Dept. of Psychiatry, Virginia Commonwealth Univ., Richmond, VA ***THE POTENTIAL FOR NUTRACEUTICALS AS TREATMENTS FOR ALCOHOL USE DISORDER
AND ALCOHOLIC LIVER DISEASE: PRECLINICAL AND CLINICAL RESEARCH
Organizer/Chair: George Kenna, Dept. of Psychiatry, Brown Univ., Providence, RI
Chairs: Giancarlo Colombo, Neuroscience Inst., National Research Council of Italy, Monserrato, Italy
and Lorenzo Leggio, CPN Section, NIAAA LCTS and NIDA IRP, NIH, Bethesda, MD
6:30 INTRODUCTION George Kenna, Dept. of Psychiatry, Brown Univ., Providence, RI EXTRACTS OF Salvia miltiorrhiza SELECTIVELY REDUCE SEVERAL ALCOHOL-MOTIVATED BEHAVIORS IN RATS Giancarlo Colombo, Neuroscience Inst., National Research Council of Italy, Monserrato, Italy THE USE OF CITICOLINE IN ALCOHOL DEPENDENCE AND OTHER ADDICTIVE DISEASES E. Sherwood Brown, Dept. of Psychiatry, Univ. of Texas Southwestern Medical Center, Dallas, TX CLINICAL OUTCOMES ASSOCIATED WITH BENFOTIAMINE TREATMENT IN CHRONIC, SEVERE ALCOHOL DEPENDENCE Ann Manzardo, Dept. of Psychiatry and Behavioral Sciences, Univ. of Kansas, Kansas City, KS METADOXINE FOR ACUTE ALCOHOL TOXICITY, ALCOHOLISM AND ALCOHOLIC LIVER DISEASE: PRECLINICAL AND CLINICAL FINDINGS George Kenna, Dept. of Psychiatry, Brown Univ., Providence, RI Lorenzo Leggio, CPN Section, NIAAA LCTS and NIDA IRP, NIH, Bethesda, MD ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
SUNDAY, JUNE 22
SUNDAY, JUNE 22
MOLECULAR ETIOLOGY OF FASD: NEW INSIGHTS FROM ANIMAL MODELS
Organizer/Chair: Abraham Fainsod, Dept. of Develop. Biology & Cancer Res., Hebrew Univ., Jerusalem, Israel
Organizer: Geoffrey Hicks, Regenerative Medicine Program, Univ. of Manitoba, Winnipeg, Manitoba, Canada
6:30 INTRODUCTION Geoffrey Hicks, Regenerative Medicine Program, Univ. of Manitoba, Winnipeg, Manitoba, Canada METHYL METABOLISM, EPIGENETIC MECHANISMS, AND PRENATAL ALCOHOL EXPOSURE Angela Devlin, Dept. of Pediatrics, Univ. of British Columbia, Vancouver, BC, Canada BIOCHEMICAL BASIS AND GENETIC PREDISPOSITION TO FETAL ALCOHOL SYNDROME Abraham Fainsod, Dept. of Developmental Biology & Cancer Research, Hebrew Univ., Jerusalem, Israel GENETICALLY MODELING FASD IN MICE Geoffrey Hicks, Regenerative Medicine Program, Univ. of Manitoba, Winnipeg, Manitoba, Canada ZEBRAFISH GENETIC SCREENS IDENTIFY ETHANOL SUSCEPTIBILITY LOCI Charles "Ben" Lovely, Molecular Biosciences and Waggoner Ctr. for Alcohol and Addiction Res., Univ. of Texas, Austin, TX Johann Eberhart, Molecular Biosciences and Waggoner Ctr. for Alcohol and Addiction Res., Univ. of Texas, Austin, TX RSA SPONSORED POST-DOC DINNER
Organized by the RSA Education Committee Chair: Sarah Pedersen If you have not already RSVPd - deadline Sunday at 12noon, if room is still available - Ticket Required.
MONDAY, JUNE 23
MONDAY, JUNE 23
CONTINENTAL BREAKFAST - Nametag Required.
RSA/ISBRA REGISTRATION DESK - Open
PLENARY SESSION II
NEUROCIRCUITRY OF APPETITE
Richard Palmiter, Ph.D., Professor of Biochemistry, School of Medicine, University of Washington, Seattle, WA Dr. Richard Palmiter received a BA in Zoology from Duke University in 1964 and PhD in Biological Sciences from Stanford in 1968. He was ap-pointed as Assistant at the University of Washington in 1974 and as Investigatory of the Howard Hughes Medical Institute in 1976. His research interests have ranged from studying the role of steroid hormones in regulation of egg white gene expression in chickens to studying regulation of zinc and cadmium biology in mice. During the 1980's he and Dr. Ralph Brinster (University of Pennsylvania) developed transgenic technol-ogy in mice and applied it to studying growth, models of human disease, and a wide range of other biological phenomena. More recently, his laboratory has been using mouse genetic techniques to study the way neurons communicate with each other, with special emphasis of neurons that make norepinephrine and dopamine. Analysis of the neurocircuitry of appetite has recently blossomed into major area of investigation. Appetite for consumption of food can be selectively activated or inhibited in mice by optogenetic or pharmacogenetic means. Activation of neurons in the arcuate hypothalamus that express agouti-related protein (AgRP) stimulates feeding, whereas inhibiting AgRP neurons blocks feeding and ablating those neurons leads to starvation. Activation of neurons in the external lateral parabrachial nucleus that express calcitonin gene-related protein (CGRP) inhibits feeding. Identifying the relevant downstream targets of the AgRP and CGRP neurons that mediate appetite and determin-ing how these orexigenic and anorexigenic circuits interactare areas of active investigation. Similar strategies may help defi nethe circuitry that controls appetite for alcohol. ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
MONDAY, JUNE 23
MONDAY, JUNE 23
COFFEE BREAK
9:30am - 11:30am SYMPOSIUM
HEAVY DRINKING AND ALCOHOL-RELATED PROBLEMS AMONG SEXUAL MINORITIES:
INVESTIGATING THE MECHANISMS UNDERLYING DISPARITIES
Organizer/Chair: Paul Gilbert, Alcohol Research Group, Emeryville, CA
9:30 INTRODUCTION Paul Gilbert, Alcohol Research Group, Emeryville, CA THE APPLICATION OF MINORITY STRESS THEORY TO BINGE DRINKING IN LESBIAN AND GAY ADOLESCENTS Jeremy Goldbach, School of Social Work, Univ. of Southern California, Los Angeles, CA LONGITUDINAL IMPACT OF PERCEIVED DISCRIMINATION ON DRINKING BEHAVIOR AMONG EMERGING ADULT LESBIAN AND BISEXUAL WOMEN Debra Kaysen, Dept. of Psychiatry & Behavioral Sciences, Univ. of Washington, Seattle, WA HEAVY DRINKING TRAJECTORIES AMONG MEN WHO HAVE SEX WITH MEN IN PROJECT EXPLORE Brandon Marshall, School of Public Health, Brown University, Providence, RI EXAMINING GAY MALE COUPLES' USE OF ALCOHOL AND DRUGS WITH SEX: DIFFERENCES BY PARTNER TYPE, ENGAGEMENT OF RISKY SEX, AND HIV STATUS Jason Mitchell, School of Nursing, Univ. of Michigan, Ann Arbor, MI Amelia Talley, Texas Tech Univ., Lubbock, TX 9:30am - 11:30am SYMPOSIUM
WHAT REALLY HAPPENS WHEN YOUNG PEOPLE DRINK ON WEEKEND NIGHTS?
NEW EVIDENCE FROM EVENT-LEVEL STUDIES
Organizer/Chair: Emmanuel Kuntsche, Addiction Switzerland, Research Institute, Lausanne Switzerland
9:30 INTRODUCTION Emmanuel Kuntsche, Addiction Switzerland, Research Institute, Lausanne, Switzerland PREDRINKING AND ITS ASSOCIATION WITH ALCOHOL USE, BAC AND ALCOHOL-RELATED HARM: A STUDY OF YOUNG ADULT BAR-GOERS Samantha Wells, Centre for Addiction and Mental Health, London, Ontario, Canada THE BIG NIGHT OUT: WHAT HAPPENS ON THE LAST HEAVY DRINKING OCCASION AMONGTS A GROUP OF YOUNG VICTORIAN RISKY DRINKERS Paul Dietze, Burnet Institute for Medical and Public Health Research, Melbourne, Australia WHEN YESTERDAY'S CONSUMPTION STRIKES BACK: DEVIATION FROM USUAL CONSUMPTION INVERSELY PREDICTS AMOUNTS CONSUMED THE NEXT WEEKEND EVENING Florian Labhart, Addiction Switzerland, Research Institute, Lausanne, Switzerland ALCOHOL CONSUMPTION AND OTHER FACTORS ASSOCIATED WITH WHETHER YOUNG FEMALE BAR-GOERS EXPERIENCE Kathryn Graham, Centre for Addiction and Mental Health, London, Ontario, Canada Clayton Neighbors, Dept. of Psychology, Univ. of Houston, Houston, TX ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
MONDAY, JUNE 23
MONDAY, JUNE 23
9:30am - 11:30am SYMPOSIUM
FROM CHILDHOOD TO ADULTHOOD? PSYCHIATRIC DISORDERS, SYMPTOMS, AND BIOLOGICAL FACTORS
INFLUENCING THE DEVELOPMENT AND COURSE OF ALCOHOL USE DISORDERS
Organizer: Kirk Brower, Univ. of Michigan, Ann Arbor, MI
Chairs: Marcin Wojnar, Medical Univ. of Warsaw, Warsaw, Poland
and Jerzy Samachowiec, Dept. of Psychiatry, Pomeranian Medical Univ., Szczecin, Poland
9:30 INTRODUCTION Marcin Wojnar, Medical Univ. of Warsaw, Warsaw, Poland PREVALENCE AND CORRELATES OF SLEEP PROBLEMS AMONG TEENAGE DRINKERS PRESENTED TO THE EMERGENCY Olena Zhabenko, Ukrainian Research Institute of Social and Forensic Psychiatry and Drug Abuse, Kiev, Ukraine RELATIONSHIPS BETWEEN A SEROTONIN TRANSPORTER GENE POLYMORPHISM (5-HTTPR), YOUTH DRINKING, AND ATTENTION DEFICIT DISORDER Jerzy Samachowiec, Dept. of Psychiatry, Pomeranian Medical Univ., Szczecin, Poland DEPRESSION AND ALCOHOL DEPENDENCE IN ADOLESCENCE: COURSE OVER 5 YEARS IN THE COGA SAMPLE Ulrich Preuss, Depts. Of Psychiatry, Psychotherapy and Psychosomatics, Halle, Germany SLEEP PROBLEMS, SELF-REGULATION AND RESILIENCE: A PROSPECTIVE STUDY Maria Wong, Idaho State Univ., Pocatello, ID Robert Zucker, Univ. of Michigan, Ann Arbor, MI 9:30am - 11:30am SYMPOSIUM
CALCIUM ACTIVATED POTASSIUM CHANNELS: INTEGRATORS AND TARGETS OF ALCOHOL SIGNALING
Organizer/Chair: Thomas Weiger, Dept. of Cell Biology, Univ. of Salzburg, Salzburg, Austria
Chair: Alejandro Dopico, Dept. of Pharmacology, Univ. of Tennessee, Memphis, TN
9:30 INTRODUCTION Thomas Weiger, Dept. of Cell Biology, Univ. of Salzburg, Salzburg, Austria A DISCRETE ETHANOL-SENSITIVE SITE IN THE CALCIUM- AND VOLTAGE-GATED POTASSIUM CHANNEL OF LARGE Anna Bukiya, Dept. of Pharmacology, College of Medicine, Univ. of Tennessee, Memphis, TN ISBRA PRESIDENT'S JUNIOR INVESTIGATOR AWARD FINALIST: MUTUAL IMPACT OF ACETALDEHYDE AND ETHANOL ON CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS IN PITUITARY (GH) CELLS Astrid Handlechner, Dept. of Cell Biology, Univ. of Salzburg, Salzburg, Austria FROM BK CHANNELS TO THE GENOME-USING HISTONE MARKS TO IDENTIFY BEHAVIORALLY-RELEVANT ALCOHOL RESPONSE GENES Nigel Atkinson, Neurobiology, Univ. of Texas, Austin, TX GENETIC CONTRIBUTION OF NUCLEUS ACCUMBENS KCNN3 LEVELS TO ALCOHOL CONSUMPTION PREDICTS DEPENDENCE-INDUCED ESCALATION OF DRINKING AND NEUROADAPTATIONS Audrey Padula, Dept. of Neurosciences, Medical Univ. of South Carolina, Charleston, SC Mark Brodie, Dept. of Physiology and Biophysics, Univ. of Illinois, Chicago, IL ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
MONDAY, JUNE 23
MONDAY, JUNE 23
9:30am - 11:30am SYMPOSIUM
***TRANSLATIONAL PERSPECTIVES ON THE ADAPTATIONS OF SYNAPTIC AND EXTRA SYNAPTIC
GABA -RECEPTORS FOR ALCOHOL INTOXICATION, DEPENDENCE AND WITHDRAWAL
Organizer/Chair: Kelly Cosgrove, School of Medicine, Yale Univ., New Haven, CT
9:30 INTRODUCTION John Krystal, Dept. of Psychiatry, Yale Univ., New Haven, CT ALCOHOL: STRUCTURAL AND BEHAVIORAL INSIGHTS FROM BACTERIAL AND RETINAL RECEPTORS Adron Harris, Waggoner Center for Alcohol and Addiction Research, Univ. of Texas, Austin, TX PROTEIN KINASE C PHOSPHORYLATION OF GABAA RECEPTORS IN RESPONSES TO ETHANOL Robert Messing, College of Pharmacy, Univ. of Texas, Austin, TX DYNAMIC ALTERATIONS IN BRAIN GABAA RECEPTORS DURING ALCOHOL WITHDRAWAL: IMAGING THE EFFECTS OF NICOTINE AND SMOKING IN MONKEYS AND HUMANS Kelly Cosgrove, School of Medicine, Yale Univ., New Haven, CT IMAGING GABA-BENZODIAZEPINE RECEPTORS WITH 11C-R015 4513 PET. Anne Lingford-Hughes, Centre for Neuropsychopharmacology, Imperial College, London, UK John Krystal, Dept. of Psychiatry, Yale Univ., New Haven, CT 9:30am - 11:30am SYMPOSIUM
***ALCOHOL USE DISORDERS IN THE INTERNATIONAL DIAGNOSTIC SYSTEMS
Organizers/Chairs: John Saunders, Univ. of Sydney, Sydney, Australia
and Karl Mann, Univ. of Heidelberg, Mannheim, Germany
9:30 INTRODUCTION John Saunders, Univ. of Sydney, Sydney, Australia THE CONTRIBUTION OF EPIDEMIOLOGY AND TAXONOMIC ANALYSIS TO UNDERSTANDING ALCOHOL USE Hans-Jurgen Rumpf, Clinic for Psychiatry and Psychotherapy, Univ. Lubeck, Lubeck, Germany WHAT CAN SCIENCE CONTRIBUTE TO A DIAGNOSTIC SYSTEM? George Koob, The Scripps Research Institute, La Jolla, CA WHAT DO CLINICIANS AND CLINICAL RESEARCHERS NEED FROM A DIAGNOSTIC SYSTEM? Colin Drummond, Institute of Psychiatry, National Addiction Centre, London, England, UK ALCOHOL USE DISORDERS: THEIR STATUS IN THE DRAFT ICD-11 Vladimir Poznyak, World Health Organization, Geneva, Switzerland Wei Hao, WHO Collaborating Centre for Drug Abuse and Health, Institute of Mental Health, Changsha Hunan, China ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
MONDAY, JUNE 23
MONDAY, JUNE 23
9:30am - 11:30am SYMPOSIUM
ETHNICITY, RISK, AND MECHANISMS FOR THE LOW RESPONSE TO ALCOHOL
AS A RISK FACTOR FOR HEAVY DRINKING AND ALCOHOL PROBLEMS
Organizer: Cindy Ehlers, The Scripps Research Institute, La Jolla, CA
Chair: Marc Schuckit, Dept. of Psychiatry, Univ. of California, La Jolla, CA
9:30 INTRODUCTION Marc Schuckit, Univ. of California, La Jolla, CA SRE-BASED LEVEL OF RESPONSE TO ALCOHOL AND ALCOHOL RELATED OUTCOMES IN >6000 SWISS ARMY RECRUITS Jean-Bernard Daeppen, Alcohol Treatment Center, Lausanne Univ. Hospital, Lausanne, Switzerland LEVEL OF RESPONSE TO ALCOHOL IN INDIVIDUALS OF EUROPEAN, ASIAN, HISPANIC AFRICAN, AND EAST INDIAN HERITAGE: RELATION TO ALDH AND ADH ENZYME VARIANTS Cindy Ehlers, The Scripps Research Institute, La Jolla, CA GENETIC INFLUENCES ON THE LEVEL OF RESPONSE TO ALCOHOL: IMPLICATIONS FOR NEW TREATMENT APPROACHES FOR ALCOHOL USE DISORDERS Mary-Anne Enoch, Human Neurogenetics, NIH/NIAAA/DICBR/LNG, Bethesda, MD DOES A "COGNITIVE INEFFICIENCY" RELATED TO THE LOW LEVEL OF RESPONSE TO ALCOHOL PREDICT LATER HEAVY DRINKING? Marc Schuckit, Dept. of Psychiatry, Univ. of California, La Jolla, CA Andrea King, Univ. of Chicago, Chicago, IL 9:30am - 11:30am SYMPOSIUM
INTERNATIONAL STUDIES ON BRAIN STRUCTURE AND FUNCTION FROM
UNCOMPLICATED ALCOHOLISM TO KORSAKOFF'S SYNDROME
Organizer/Chair: Tilman, Neuroscience Program, SRI International, Menlo Park CA
Chair: Edith Sullivan, Psychiatry & Behavioral Sciences, Stanford Univ., Stanford, CA
9:30 INTRODUCTION Tilman Schulte, Neuroscience Program, SRI International, Menlo Park, CA RSA MEMORIAL AWARDEE - HETEROGENEITY OF ALCOHOL EFFECTS ON NODES OF FRONTOCEREBELLAR AND LIMBIC CIRCUITRY: EVIDENCE FROM THE U.S.-FRANCE COLLABORATIVE STUDY Anne-Pascale Le Berre, Psychiatry & Behavioral Sciences, Stanford Univ., Stanford, CA THE USE OF MULTIMODAL IMAGING TO ENHANCE THE PATHOPHYSIOLOGY OF ALCOHOLIC BRAIN DAMAGE Anne-Lise Pitel, Univ. de Caen/Basse-Normandie, Normandie, France ASSESSMENT OF BRAIN NETWORKS IN ALCOHOLISM USING FUNCTIONAL MAGNETIC RESONANCE IMAGING Patrick Bach, Central Institute for Mental Health, Mannheim, Germany BRAIN NETWORK CONNECTIVITY CHANGES OVER TIME IN CHRONIC ALCOHOLICS Eva Muller-Oehring, Psychiatry & Behavior Sciences, Stanford, Univ., Stanford, CA Adolf Pfefferbaum, Neuroscience Program, SRI International, Menlo Park, CA 11:45am - 1:45pm RSA ANNUAL LEGISLATIVE ADVOCACY WORKSHOP - OPEN
Organized by the RSA Government Affairs and Advocacy Committee Chairs: Susan Barron, Victor Hesselbrock and Sara Jo Nixon Everyone Welcome - Light Lunch available for those who RSVP'd in advance - ticket required ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
MONDAY, JUNE 23
MONDAY, JUNE 23
11:45am - 1:45pm ISBRA BOARD OF DIRECTORS MEETING
OPEN TO 2014-2018 BOARD MEMBERS International Society for Biomedical Research on Alcoholism Board Meeting and Lunch SYMPOSIUM
CONTEXTS MATTER: HOW DO DRINKING CONTEXTS ALTER
RELATIONSHIPS BETWEEN ALCOHOL AND RELATED PROBLEMS?
Organizer: Christina Mair, Dept. of Behavioral and Community Health Sciences, Univ. of Pittsburgh, Pittsburgh, PA
Organizer/Chair: Sharon Lipperman-Kreda, Prevention Research Center, Oakland, CA
2:00 INTRODUCTION Christina Mair, Dept. of Behavioral and Community Health Sciences, Univ. of Pittsburgh, Pittsburgh, PA ALCOHOL AND FATAL INJURY IN ADOLESCENTS, THEIR FAMILIES, AND THEIR NEIGHBORHOODS Shari Wiley, Dept. of Biostatistics and Epidemiology, Univ. of Pennsylvania, Philadelphia, PA WHO DRINKS WHERE: THE DISTRIBUTION OF DRINKING IN PARTICULAR CONTEXTS AMONG YOUTHS Sharon Lipperman-Kreda, Prevention Research Center, Oakland, CA DRINKING CONTEXT-SPECIFIC ASSOCIATIONS BETWEEN FREQUENCY AND VOLUME OF YOUTH ALCOHOL USE AND ALCOHOL-RELATED Christina Mair, Dept. of Behavioral and Community Health Sciences, Univ. of Pittsburgh, PA UNDERSTANDING THE ROLE OF CONTEXT-SPECIFIC DRINKING IN NEGLECTFUL PARENTING BEHAVIORS Bridget Freisthler, Dept. of Social Welfare, Univ. of California, Los Angeles, CA Paul Gruenewald, Prevention Research Center, Oakland, CA SYMPOSIUM
MULTIDISCIPLINARY PERSPECTIVES ON THE PATHWAYS OF INFLUENCE
BETWEEN IN-THE-MOMENT ALCOHOL USE AND HIV RISK-TAKING BEHAVIORS
Organizer/Chair: Stephanie Staras, Dept. of Health Outcomes and Policy, Univ. of Florida, Gainesville, FL
2:00 INTRODUCTION Stephanie Staras, Dept. of Health Outcomes and Policy, Univ. of Florida, Gainesville, FL DOES DRINKING IMPROVE THE QUALITY OF ONE'S SEXUAL EXPERIENCE? Lynne Cooper, Dept. of Psychological Science, Univ. of Missouri, Columbia, MO EFFECTS OF ALCOHOL CONSUMPTION AND EXPECTANCIES ON YOUNG MEN'S RISKY SEX JUDGMENTS DURING Tina Zawacki, Univ. of Texas, San Antonio, TX ADOLESCENT IN-THE-MOMENT ALCOHOL USE IS ASSOCIATED WITH HAVING A RISKIER SEXUAL PARTNER Stephanie Staras, Dept. of Health Outcomes and Policy, Univ. of Florida, Gainesville, FL EVENT-LEVEL APPLICATION OF THE COGNITIVE MEDIATION MODEL: INFLUENCE OF ALCOHOL AND PARTNER TYPE Jeannette Norris, Univ. of Washington, Seattle, WA William George, Dept. of Psychology, Univ. of Washington, Seattle, WA ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
MONDAY, JUNE 23
MONDAY, JUNE 23
SYMPOSIUM
MONOCYTES/MACROPHAGES: CENTRAL REGULATORS OF ALCOHOLIC
LIVER INJURY AND DISEASE PROGRESSION
Organizers/Chairs: Pranoti Mandrekar, Univ. of Massachusetts Medical School, Worcester, MA
and Laura Nagy, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
2:00 INTRODUCTION Pranoti Mandrekar, Univ. of Massachusetts Medical School, Worcester, MA COMPLEMENT RECEPTOR C5AR IS INVOLVED IN MACROPHAGE-INDUCED CYTOKINE PRODUCTION AND HEPATOCYTE DAMAGE IN ALCOHOLIC LIVER DISEASE R.L. Smathers-McCullough, Lerner Research Institute, Cleveland Clinic, Cleveland, OH LINKING ER STRESS AND INFLAMMATORY CELL ACTIVATION IN ALCOHOLIC LIVER INJURY: ROLE FOR GP96 Pranoti Mandrekar, Univ. of Massachusetts Medical School, Worcester, MA NOTCH LINKS MITOCHONDRIAL METABOLISM TO M1 MACROPHAGE ACTIVTAION Jun Xu, Dept. of Pathology, Univ. of Southern California, Los Angeles, CA TOLL-LIKE RECEPTOR 3 IS A NOVEL THERAPEUTIC TARGET FOR ALCOHOLIC LIVER INJURY Won-Il Jeong, Laboratory of Liver Research, Daejeon, Korea Laura Nagy, Lerner Research Institute, Cleveland Clinic, Cleveland, OH SYMPOSIUM
***THE ROLE OF SOCIAL NETWORKS IN RECOVERY FROM ALCOHOL
USE DISORDERS: BRAIN IMAGING, CLINICAL, AND NEW ANIMAL MODELS
Organizer/Chair: Vivia McCutcheon, Washington Univ. School of Medicine, Saint Louis, MO
2:00 INTRODUCTION Vivia McCutcheon, Washington Univ. School of Medicine, Saint Louis, MO SENSITIVITY OF ALCOHOL-DEPENDENT SUBJECTS TO SELF-THREATENING SITUATIONS INCLUDING SOCIAL EXCLUSION: NEURAL CORRELATES AND DRINKING TENDENCY Philippe de Timary, Dept. of Adult Psychiatry, Catholic Univ. of Louvain, Brussels, Belgium SOCIAL SUPPORT AS AN ALTERNATIVE PROCESS FOR INITIATING AND MAINTAINING POSITIVE BEHAVIORAL CHANGE Jennifer Buckman, Center of Alcohol Studies, Rutgers Univ., Piscataway, NJ YOUNG ADULTS, SOCIAL NETWORKS, AND ADDICTION RECOVERY John Kelly, Harvard Medical School, Boston, MA RECENT ADVANCES IN MODELING THE SOCIAL INFLUENCES ON ALCOHOL INTAKE AND RELAPSE IN ANIMALS Andrey Ryabinin, Dept. of Behavioral Neuroscience, Oregon Health and Science Univ., Portland, OR Jon Morgenstern, Columbia Univ. Medical Center, New York, NY ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
MONDAY, JUNE 23
MONDAY, JUNE 23
SYMPOSIUM
***BYPASSING SWEETS FOR ALCOHOL: A TRANSLATIONAL PERSPECTIVE
ON WEIGHT-LOSS SURGERIES AND INCREASED ALCOHOL ADDICTION
Organizers/Chairs: M. Yanina Pepino, School of Medicine, Washington Univ., St. Louis, MO
and Andras Hajnal, College of Medicine, Penn State Univ., Hershey, PA
2:00 INTRODUCTION M. Yanina Pepino, School of Medicine, Washington Univ., St. Louis, MO ALCOHOL REWARD AFTER ROUX-EN-Y GASTRIC BYPASS IN DIET-INDUCED OBESE RATS Andras Hajnal, College of Medicine, Penn State Univ., Hershey, PA ALCOHOL METABOLISM AND THE SUBJECTIVE RESPONSE TO ALCOHOL AFTER BARIATRIC SURGERY IN WOMEN M. Yanina Pepino, School of Medicine, Washington Univ., St. Louis, MO ALCOHOL USE FOLLOWING BARIATRIC WEIGHT LOSS SURGERY Allan Geliebter, St. Luke's Roosevelt Hospital Center, New York, NY ROUX-en-Y GASTRIC BYPASS SURGERY AND ADDICTION TRANSFER Karen Saules, Eastern Michigan Univ., Ypsilanti, MI Kathleen Bucholz, School of Medicine, Washington Univ., St. Louis, MO SYMPOSIUM
***IMPACT OF FETAL ETHANOL EXPOSURE ON SOCIO-EMOTIONAL DEVELOPMENT IN HUMANS AND RODENTS
Organizers/Chairs: C. Fernando Valenzuela, Dept. of Neurosciences, Univ. of New Mexico, Albuquerque, NM
and Marvin Diaz, Dept. of Neurosciences, Univ. of New Mexico, Albuquerque, NM
2:00 INTRODUCTION C. Fernando Valenzuela, Univ. of New Mexico School of Medicine, Albuquerque, NM SLEEP, SELF-REGULATION, AND BEHAVIOUR IN CHILDREN WITH FETAL ALCOHOL SPECTRUM DISORDER (FASD) Ana Hanlon-Dearman, Pediatrics and Child Health, Univ. of Manitoba, Winnipeg, Canada SEX, AGE, AND TIMING OF ALCOHOL EXPOSURE DEFINE BEHAVIORAL AND MOLECULAR OUTCOMES Sandra Mooney, Dept. of Pediatrics, Univ. of Maryland School of Medicine, Baltimore, MD LOW DOSE PRENATAL ETHANOL EXPOSURE INDUCES ANXIETY-LIKE BEHAVIOUR BUT DOES NOT AFFECT LEARNING AND MEMORY IN RAT OFFSPRING Karen Moritz, School of Biomedical Sciences, Univ. of Queensland, Queensland, Australia ALCOHOL EXPOSURE DURING THE 3RD TRIMESTER-EQUIVALENT DISRUPTS DOPAMINE MODULATION OF GABA TRANSMISSION IN THE BASOLATERAL AMYGDALA DURING ADOLESCENCE Marvin Diaz, Univ. of New Mexico School of Medicine, Albuquerque, NM C. Fernando Valenzuela, Univ. of New Mexico School of Medicine, Albuquerque, NM ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
MONDAY, JUNE 23
MONDAY, JUNE 23
SYMPOSIUM
***FRONT AND CENTER: ALCOHOL AND THE FRONTAL CORTEX:
RESULTS FROM ANIMAL MODELS AND HUMAN SUBJECTS
Organizers/Chairs: John Woodward, Medical Univ. of South Carolina, Charleston, SC
and Patrick Mulholland, Medical Univ. of South Carolina, Charleston, SC
2:00 INTRODUCTION Antoine Bechara, Dept. of Psychiatry and Brain and Creativity Institute, Univ. of Southern California, Los Angeles, CA ELECTROPHYSIOLOGICAL AND BEHAVIORAL ACTIONS OF ALCOHOL ON ORBITOFRONTAL CORTEX John Woodward, Dept. of Neurosciences, Medical Univ. of South Carolina, Charleston, SC HUMAN STUDIES OF IMPULSIVE CHOICE: ALCOHOL USE DISORDERS AND THE FRONTAL CORTEX Charlotte Boettiger, Dept. of Psychology and Biomedical Research Imaging Ctr., Univ. of North Carolina, Chapel Hill, NC MECHANISMS UNDERLYING ETHANOL INDUCED DYSFUNCTIONAL CORTICAL BASED BEHAVIORS Fulton Crews, Depts. Of Pharmacology and Psychiatry, Univ. of North Carolina, Chapel Hill, NC CHRONIC ALCOHOL-INDUCED NEUROADAPTATIONS IN TRIPARTITE SYNAPSES IN THE ORBITOFRONTAL CORTEX IDENTIFIED BY DUAL QUANTITATIVE PROTEOMICS Patrick Mulholland, Dept. of Neurosciences, Medical Univ. of South Carolina, Charleston, SC Peter Dodd, School of Chemistry and Molecular Biosciences, Univ. of Queensland, Brisbane, Queensland, Australia SYMPOSIUM
PERSONALIZED TREATMENT OF ALCOHOL USE DISORDER
Organizer/Chair: Henry Kranzler, Univ. of Pennsylvania, Philadelphia, PA
Chair: Raymond Anton, Medical Univ. of South Carolina, Charleston, SC
2:00 INTRODUCTION Lara Ray, Univ. of South California, Los Angeles, CA PHAMRACOGENETIC TREATMENT OF ALCOHOL DEPENDENCE WITH ONDANSETRON Bankole Johnson, Univ. of Maryland, Baltimore, MD PROSPECTIVE STUDY OF ASN40ASP AS A MODERATOR OF NALTREXONE TREATMENT OF ALCOHOL DEPENDENCE David Oslin, Pereleman School of Medicine, Univ. of Pennsylvania and Philadelphia VAMC, Philadelphia, PA 5-HTTLPR MODERATES NALTREXONE AND PSYCHOSOCIAL TREATMENT RESPONSES IN HEAVY DRINKERS Andrew Chen, Dept. of Psychiatry, Columbia Univ., New York, NY GRIK1 MODERATES THE RESPONSE TO TOPIRAMATE IN HEAVY DRINKERS Henry Kranzler, Dept. of Psychiatry, Univ. of Pennsylvania, Philadelphia, PA David Goldman, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD POSTER SESSION II
POSTER NUMBERS: 1-291 / ABSTRACT NUMBERS: 293-583
two 1-hour manning periods - Number 1 fi rst hour; number 2 second hour, fi nal 30 minutes unmanned period (light refreshments) ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
MONDAY, JUNE 23
MONDAY, JUNE 23
PAPER SESSION
ENOCH GORDIS AWARD FINALISTS - POSTDOCS
MODERATOR: Donita Robinson
Robinson INTRODUCTION Jacqueline Barker ENHANCED MGLUR2 SIGNALING RESCUES DEPENDENCE-INDUCED DEFICITS IN FLEXIBLE ALCOHOL- COMBINING LINKAGE ANALYSIS AND EXOME SEQUENCING IDENTIFIES A NOVEL GENE ASSOCIATED WITH RISK OF ALCOHOL DEPENDENCE IN LARGE COGA FAMILIES ASSOCIATION AND ANCESTRY ANALYSIS OF ADH AND ALDH VARIANTS WITH ALCOHOL-RELATED PHENOTYPES IN A NATIVE AMERICAN COMMUNITY SAMPLE PREDICTION AND VALIDATION OF ALCOHOL DEPENDENCE SEVERITY FROM NEURAL FUNCTIONAL CONNECTIVITY DURING ALCOHOL CUE EXPOSURE ETHANOL ENHANCES GLUTAMATERGIC TRANSMISSION IN THE CENTRAL AMYGDALA VIA A CRF RECEPTOR DEPENDENT MECHANISM Petra Suchankova GENETIC VARIATION AT THE GLUCAGON-LIKE PEPTIDE-1 RECEPTOR GENE LOCUS IS ASSOCIATED WITH ALCOHOL USE DISORDER CLIENT SPEECH AS A BIOMARKER FOR CHANGE IN ALCOHOL AND DRUG USE
Organizer/Chair: Jon Houck, Univ. of New Mexico, Albuquerque, NM
Organizer: Lisa Glynn, Univ. of New Mexico and VA Puget Sound Health Care System, Seattle, WA
6:30 INTRODUCTION Lisa Glynn, Univ. of New Mexico and VA Puget Sound Health Care System, Seattle, WA WITHIN-SESSION COMMUNICATION PATTERNS PREDICT ALCOHOL TREATMENT OUTCOMES Jon Houck, Center on Alcoholism, Substance Abuse, and Addictions, Univ. of New Mexico, Albuquerque, NM CHANGE TALK DURING BRIEF MOTIVATIONAL INTERVENTION WITH YOUNG MEN WITH HAZARDOUS ALCOHOL USE: STRENGTH MATTERS Jacques Gaume, Dept. of Comm. Health, Med. & Alcohol Treatment Ctr., Lausanne Univ. Hosp., Lausanne, Switzerland CHANGE TALK AND COUNTER-CHANGE TALK AS MARKERS OF BEHAVIORAL CHANGE IN ALCOHOL BEHAVIORAL COUPLES THERAPY Adrienne Borders, Center on Alcoholism, Substance Abuse, and Addictions, Univ. of New Mexico, Albuquerque, NM ARE CHANGE TALK AND SUSTAIN TALK "CONTAGIOUS" IN GROUPS? SEQUENTIAL PROBABILITIES AND SAFER-SEX OUTCOMES IN ALCOHOL- AND MARIJUANA-USING ADOLESCENTS. Lisa Glynn, Univ. of New Mexico and VA Puget Sound Health Care System, Seattle, WA Paul Amrhein, Therapeutic Language Laboratory, Columbia Univ., New York, NY ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
MONDAY, JUNE 23
MONDAY, JUNE 23
NEUROENDOCRINE MECHANISMS OF STRESS: INFLUENCES ON
ETHANOL AND DRUG SELF-ADMINISTRATION IN ANIMAL MODELS
Organizer/Chair: Christa Helms, Oregon National Primate Research Center, Beaverton, OR
6:30 INTRODUCTION Kathleen Grant, Dept. of Behavioral Neuroscience, Oregon Health & Science Univ., Portland, OR ALDOSTERONE RESPONSE TO MILD STRESS AND ETHANOL SELF-ADMINISTRATION AMONG RHESUS MACAQUES Christa Helms, Div. of Neuroscience, Oregon Nation Primate Research Center, Beaverton, OR PRENATAL ALCOHOL EXPOSURE INCREASES SENSITIVITY TO AMPHETAMINE SENSITIZATION AND CROSS-SENSITIZATION WITH STRESS IN THE RAT Joanne Weinberg, Dept. of Cellular and Physiological Sciences, Univ. of British Columbia, Vancouver, Canada BLUNTED SENSITIVITY TO ALCOHOL INTEROCEPTIVE CUES FOLLOWING CORTICOSTERONE EXPOSURE IN RATS Joyce Besheer, Dept. of Psychiatry, Bowles Center for Alcohol Studies, Univ. of North Carolina, Chapel Hill, NC DIFFERENT SOCIAL STRESSORS ESCALATE PSYCHOMOTOR STIMULANT AND ALCOHOL SELF-ADMINISTRATION: ROLE OF CRF MODULATION OF ACCUMBAL DOPAMINE Klaus Miczek, Dept. of Psychology, Tufts Univ., Medford, MA Kathleen Grant, Dept. of Behavioral Neuroscience, Oregon Health & Science Univ., Portland, OR ***TRIBUTE TO DR. RONALD ALKANA: RECENT PROGRESS & CHALLENGES IN DRUG DISCOVERY
& DRUG DEVELOPMENT FOR ALCOHOL USE DISORDERS IN THE UNIVERSITY SETTING
Organizer/Chair: Daryl Davies, School of Pharmacy, Univ. of Southern California, Los Angeles, CA
Chair: Bo Soderpalm, Addiction Biology Unit, Univ. of Gothenburg, Goteborg, Sweden
TRIBUTE TO DR. RONALD ALKANA James Trudell, Stanford University, Dept. of Anesthesia, Stanford, CA 6:32 INTRODUCTION Mia Ericson, Addiction Biology Unit, Sec. of Psychiatry, Univ. of Gothenburg, Gothenburg, Sweden HUMAN LABORATORY MODELS IN MEDICATION DEVELOPMENT FOR ALCOHOL USE DISORDERS: OPPORTUNITIES, CHALLENGES, AND RECENT FINDINGS Daniel Roche, Dept. of Psychology, Univ. of California, Los Angeles, CA WILL INQUIRIES INTO THE PATHOPHYSIOLOGY OF ALCOHOLISM BE MORE REWARDING THAN STUDIES OF THE PHARMACOLOGY OF ETHANOL? Bo Soderpalm, Addiction Biology Unit, Univ. of Gothenburg, Goteborg, Sweden DEVELOPMENT OF NOVEL COMPOUNDS FOR THE TREATMENT OF ALCOHOL USE DISORDERS Daryl Davies, School of Pharmacy, Univ. of Southern California, Los Angeles, CA RSA MEMORIAL AWARDEE - EXAMINATION OF COMPOUNDS ACTIVE AT GABA RECEPTORS FOR EFFECTS ON ETHANOL INTAKE AND ETHANOL SEEKING IN MICE Marcia Ramaker, VA Medical Research and Dept. of Behavioral Neuroscience, Oregon Health & Science Univ., Portland, OR Deborah Finn, VA Medical Center and Dept. of Behavioral Neuroscience, Oregon Health & Science Univ., Portland, OR ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
TUESDAY, JUNE 24
TUESDAY, JUNE 24
CONTINENTAL BREAKFAST - Nametag required.
RSA/ISBRA REGISTRATION DESK - Open
PLENARY SESSION III
UNDERSTANDING FIREWATER: RISK FACTORS FOR ALCOHOLISM IN NATIVE AMERICANS
RSA DISTINGUISHED RESEARCHER AWARDEE (2014)
Cindy Ehlers, Ph.D., Professor, The Scripps Research Institute, Molecular and Cellular Neurosciences Department and Molecular and Experimental Medicine, La Jolla, CA Dr. Cindy L. Ehlers received her Ph.D. in Physiology with a minor in Pharmacology from the University of California, Davis (1973-1977). Dr. Ehlers then studied as a Giannini Foundation Fellow in the Department of Anatomy and Brain Research Institute at the University of California, Los Angeles (1977-1979) and then fi nished her postdoctoral studies at The Salk Institute for Biological Studies (1979-1983). Dr. Ehlers joined the Molecular and Integrative Neurosciences Department at The Scripps Research Institute as faculty in 1983. Dr. Ehlers is also an Adjunct Professor of Psychiatry at the University of California, San Diego, CA and at the University of Pittsburgh, Pittsburgh, PA. Dr. Ehlers has published extensively with over 250 journal articles. She has received the Ronald Thurman Lectureship Award and the Wendy and Stanley Marsh endowed lectureship award. She has been funded continuously from NIAAA since 1983 for her translational studies of risk factors for alcoholism. She is currently a co-director of a NIAAA-supported Alcohol Research Center. Although tribes differ with regard to the use of alcohol and drugs, alcohol dependence is one of the most important sources of health problems facing Native Americans. Our studies have focused on identifying genetic and social/environmental risk factors for alcohol dependence in a group of reservation dwelling Native Americans that have high lifetime rates of alcohol dependence. Our studies suggest that the high rates of substance dependence seen in these tribes is likely a combination of a lack of genetic protective factors such as the alcohol metabolizing enzyme variants that are seen in Asian and African Americans, combined with genetically mediated risk factors such as externalizing traits, EEG variants, and a low level of response to alcohol. There are also key environmental/social factors such as: early age of onset of alcohol use, trauma exposure, historical trauma, and environmental hardship/contingencies that contribute to an overall increased risk for the disorder. COFFEE BREAK
9:30am - 11:30am SYMPOSIUM
INTERPLAY BETWEEN APPETITIVE BIAS AND INHIBITORY CONTROL IN ADDICTIVE BEHAVIORS
Organizer: Jessica Weafer, Psychiatry and Behavioral Neuroscience, Univ. of Chicago, Chicago, IL
Organizer/Chair: Mark Fillmore, Univ. of Kentucky, Lexington, KY
9:30 INTRODUCTION Bruce Bartholow, Univ. of Missouri, Columbia, MO 9:40 DRUG-RELATED POTENTIATE ALCOHOL IMPAIRMENT OF BEHAVIORAL CONTROL IN ALCOHOL AND COCAINE ABUSERS Jessica Weafer, Psychiatry and Behavioral Neuroscience, Univ. of Chicago, Chicago, IL RSA MEMORIAL AWARDEE - LOW SENSITIVITY TO ALCOHOL IS CHARACTERIZED BY IMPLICIT APPROACH AND IMPAIRED Kimberly Fleming, Dept. of Psychological Sciences, Univ. of Missouri, Columbia, MO PREDICTING DYSCONTROLLED DRINKING IN THE LAB WITH AN IMPLICIT MEASURE OF ALCOHOL MOTIVATION AND Ostafi n, Dept. of Psychology, Univ. of Groningen, Groningen, The Netherlands INHIBITION OF AUTOMATICALLY TRIGGERED APPROACH-TENDENCIES Reinout Wiers, Dept. of Psychology, Univ. of Amsterdam, Amsterdam, The Netherlands Kenneth Sher, Dept. of Psychology, Univ. of Missouri, Columbia, MO ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
TUESDAY, JUNE 24
TUESDAY, JUNE 24
9:30am - 11:30am SYMPOSIUM
ALCOHOL'S ROLE IN SEXUAL ASSAULT PERPETRATION: INNOVATIONS IN RESEARCH METHODS
Organizers/Chairs: Rhiana Wegner, Dept. of Psychology, Wayne State Univ., Detroit, MI
and Antonia Abbey, Dept. of Psychology, Wayne State Univ., Detroit, MI
9:30 INTRODUCTION Antonia Abbey, Dept. of Psychology, Wayne State Univ., Detroit, MI THE ROLES OF ALCOHOL CONSUMPTION AND EXPECTANCIES IN SEXUAL AGGRESSION INCIDENTS Kelly Cue Davis, School of Social Work, Univ. of Washington, Seattle, WA THE TEMPORAL ASSOCIATION BETWEEN DRINKING AND SEXUAL AGGRESSION IN COLLEGE MEN Maria Testa, Research Institute on Addictions, Univ. at Buffalo, Buffalo, NY THE EFFECT OF ACUTE ALCOHOL INTOXICATION ON MEN'S PERCEPTIONS OF A WOMAN'S SEXUAL INTENT AND POST- Rhiana Wegner, Dept. of Psychology, Wayne State Univ., Detroit, MI DEVELOPMENT OF VIRTUAL REALITY DATING SIMULATION TO ASSESS SEXUAL AGGRESSION IN ALCOHOL ADMINISTRATION STUDIES Antonia Abbey, Dept. of Psychology, Wayne State Univ., Detroit, MI Robert Freeman, Division of Epidemiology and Prevention Research, NIAAA, Bethesda, MD 9:30am - 11:30am PSYCHOSIS AND CO-OCCURRING SUBSTANCE USE DISORDER:
NEURAL CIRCUITRY, MODELS AND NEW TREATMENT DEVELOPMENT
Organizer/Chair: Alan Green, Dept. of Psychiatry, Geisel School of Medicine, Dartmouth, Lebanon, NH
Organizer: Jerome Jeanblanc, Univ. de Picardie Jules Vern, Amiens, France
Chair: Mickael Naassila, Univ. de Picardie Jules Verne, Amiens, France
9:30 INTRODUCTION Jibran Khokhar, Depts. of Psychiatry and Pharmacology & Toxicology, Geisel School of Medicine, Dartmouth, Lebanon, NH ALCOHOLISM IN PATIENTS WITH SCHIZOPHRENIA: A UNIFYING HYPOTHESIS? Alan Green, Dept. of Psychiatry, Geisel School of Medicine, Dartmouth, Lebanon, NH ALCOHOL INTAKE DURING ADOLESCENCE INDUCES ALCOHOL ADDICTION IN AN ANIMAL MODEL OF SCHIZOPHRENIA Jerome Jeanblanc, Research Group on Alcohol & Pharmacodependences, Univ. de Picardie Jules Verne, Amiens, France THE ROLE OF CLOCK IN ETHANOL-RELATED BEHAVIOURS: IMPLICATIONS FOR BIPOLAR DISORDER AND ALCOHOLISM. Colleen McClung, Psychiatry Dept., Univ. of Pittsburgh School of Medicine, Pittsburgh, PA LESSONS FROM CLOZAPINE: TOWARD TREATMENT DEVELOPMENT FOR ALCOHOL USE DISORDER AND SCHIZOPHRENIA Jibran Khokhar, Depts. of Psychiatry and Pharmacology & Toxicology, Geisel School of Medicine, Dartmouth, Lebanon, NH Mickael Naassila, Research Group on Alcohol and Pharmacodependences, Univ. de Picardie Jules Verne, Amiens, France ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
TUESDAY, JUNE 24
TUESDAY, JUNE 24
9:30am - 11:30am SYMPOSIUM
ETHANOL ON BRAIN CHOLESTEROL AND CHOLESTEROL-RICH STRUCTURES (MYELIN,
LIPID RAFTS, AND LIPOPROTEINS): MECHANISMS AND FUNCTIONAL CONSEQUENCES
Organizers/Chairs: Marina Guizzetti, Univ. of Illinois and Jesse Brown VA Medical Center, Chicago, IL
and Cynthia Bearer, Div. of Neonatology, Univ. of Maryland School of Medicine, Baltimore, MD
9:30 INTRODUCTION Marina Guizzetti, Dept. of Psychiatry, Univ. of Illinois and Jesse Brown VA Medical Center, Chicago, IL CHOLINE PARTIALLY PREVENTS ETHANOL DISRUPTION OF LIPID RAFT DEPENDENT FUNCTIONS OF L1 CELL ADHESION Cynthia Bearer, Div. of Neonatology, Univ. of Maryland School of Medicine, Baltimore, MD CHOLESTEROL MODULATION OF BK CHANNEL GATING: MANY DISTINCT SITES TOWARDS A COMMON GOAL Alejandro Dopico, Dept. of Pharmacology, Univ. of Tennessee Health Science Center, Memphis TN ETHANOL PROMOTES TLR4 SIGNALING AND MYELIN DISRUPTION BY INTERACTING WITH MEMBRANE "LIPID RAFTS" Consuelo Guerri, Centro de Investigacion Principe Felipe, Valencia, Spain ALCOHOL EFFECTS ON CHOLESTEROL TRANSPORTERS, LIPOPROTEINS, AND CHOLESTEROL LEVELS IN BRAIN CELLS Marina Guizzetti, Dept. of Psychiatry, Univ. of Illinois and Jesse Brown VA Medical Center, Chicago, IL Cynthia Bearer, Div. of Neonatology, Univ. of Maryland School of Medicine, Baltimore, MD 9:30am - 11:30am SYMPOSIUM
NEUROENDOCRINE MECHANISMS OF STRESS AND ADDICTION
Organizer/Chair: Annie Whitaker, Louisiana State Univ. Health Science Center, New Orleans, LA
Chair: Rajita Sinha, Yale Univ., New Haven, CT
9:30 INTRODUCTION Annie Whitaker, Louisiana State Univ. Health Science Center, New Orleans, LA STRESS IN THE DEVELOPMENT, MAINTENANCE, AND REINSTATEMENT OF ADDICTIVE BEHAVIORS James Herman, Dept. of Psychiatry and Behavioral Neuroscience, Univ. of Cincinnati, Cincinnati, OH SYSTEMIC OR INTRA-CENTRAL AMYGDALA GLUCOCORTICOID RECEPTOR ANTAGONISM BLOCKS COMPULSIVE ALCOHOL DRINKING IN RATS Leandro Vendruscolo, The Scripps Research Institute, La Jolla, CA ADRENERGIC RECEPTORS MEDIATE ANXIETY-LIKE BEHAVIORS IN HIGH AND LOW STRESS REACTIVE RODENTS Annie Whitaker, Louisiana State Univ. Health Science Center, New Orleans, LA POST TRAUMATIC STRESS DISORDER (PTSD) AND ALCOHOL USE DISORDERS: NEUROBIOLOGY, CLINICAL MANIFESTATIONS AND TREATMENT STRATEGIES Ismene Petrakis, Dept. of Psychiatry, Yale Univ. School of Medicine, & VA Connecticut Healthcare System, West Haven, CT Rajita Sinha, Dept. of Psychiatry, Yale Univ., Cincinnati, OH ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
TUESDAY, JUNE 24
TUESDAY, JUNE 24
9:30am - 11:30am SYMPOSIUM
BIOLOGICAL AND ENVIRONMENTAL RISK FACTORS FOR ALCOHOL USE DISORDER:
LONGITUDINAL TRAJECTORIES, AN INTERNATIONAL PERSPECTIVE
Organizers/Chairs: Michie Hesselbrock, Dept. of Psychiatry, Univ. of Connecticut School of Med., Farmington, CT
and Susumu Higuchi, National Hospital Organization, Kurihama Alcoholism Center, Yokosuka, Japan
9:30 INTRODUCTION Michie Hesselbrock, Dept. of Psychiatry, Univ. of Connecticut School of Medicine, Farmington, CT TRAJECTORIES OF BRAIN DEVELOPMENT IN ADOLESCENTS AND THEIR MODERATION BY SUBSTANCE USE. Gunter Schumann, Biological Psychiatry, King's College, London, England LEVEL OF RESPONSE TO ALCOHOL AND ALCOHOL RELATED PROBLEMS IN YOUNG JAPANESE ADULTS Sachio Matsushita, National Hospital Organization, Kurihama Alcoholism Center, Yokosuka, Japan A LONGITUDINAL STUDY OF GENETIC AND ENVIRONMENTAL INFLUENCES ON SUBSTANCE USE AMONG COLLEGE Danielle Dick, Dept. of Psychiatry, Virginia Commonwealth Univ., Richmond, VA DEVELOPMENTAL TRAJECTORIES OF ALCOHOL AND SUBSTANCE USE DISORDERS IN A HIGH RISK SAMPLE Victor Hesselbrock, Dept. of Psychiatry, Univ. of Connecticut School of Medicine, Farmington, CT Maria Formigoni, Sociologia do Abuso de Drogas de Psicobiologia-Escola Paulista de Medicina Univ., Sao Paulo, Brazil 9:30am - 11:30am SYMPOSIUM
***SEQUENCE AND EXPRESSION VARIATION DEFINING NEUROBIOLOGY AND PSYCHIATRIC DISEASE IN PRIMATES
Organizer/Chair: R. Dayne Mayfi eld, Univ. of Texas, Austin, TX
Organizer: Sean Farris, Waggoner Center for Alcohol and Addiction Research, Univ. of Texas, Austin, TX
9:30 INTRODUCTION R. Dayne Mayfi eld, Univ. of Texas, Austin, TX SEQUENCING THE TRANSCRIPTOME IN ETHANOL CONSUMING RHESUS MACAQUES Robert Hitzemann, Oregon Health & Science Univ. & VA Research Service, Portland, OR GWAS OF ALCOHOL DEPENDENCE TRAITS IN AMERICAN POPULATIONS Joel Gelernter, Psychiatry, Genetics, and Neurobiology, Yale School of Medicine, West Haven, CT DEFINING GENETIC NETWORKS FROM HUMAN POSTMORTEM BRAIN TISSUE Sean Farris, Waggoner Center for Alcohol and Addiction Research, Univ. of Texas, Austin, TX LARGE SCALE DIGITAL ATLASES IN NEUROSCIENCE Michael Hawrylycz, Allen Institute for Brain Science, Seattle, WA John Krystal, Psychiatry and Neurobiology, Yale School of Medicine, West Haven, CT ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
TUESDAY,
TUESDAY,
9:30am - 11:30am SYMPOSIUM
***FINDING THE ROADS TO ALCOHOLISM TREATMENT AND RELAPSE PREVENTION
Organizer/Chair: Boris Tabakoff, Skaggs Sch. of Pharm. & Pharmaceutical Sciences, Univ. of Colorado, Aurora, CO
Chair: Barbara Mason, The Scripps Research Institute, La Jolla, CA
9:30 INTRODUCTION Barbara Mason, The Scripps Research Institute, La Jolla, CA MGLUR2 AGONISTS FOR RELAPSE PREVENTION Rainer Spanagel, Dept. of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany NETWORK PHARMACOLOGY APPROACH TO TREATMENT OF ALCOHOLISM Boris Tabakoff, Skaggs School of Pharmacy and Pharmaceutical Sciences, Univ. of Colorado, Aurora, CO DUAL MECHANISM FOR NEUROKININ 1 (NK1) RECEPTOR ANTAGONISM AS A THERAPEUTIC TARGET IN ADDICTIVE DISORDERS Markus Heilig, National Institute of Health, NIAAA, Bethesda, MD CLINICAL VALIDATION OF CENTRAL STRESS SYSTEMS AS A PHARMACOLOGICAL TARGET IN TREATING ALCOHOLISM: A RANDOMIZED CONTROLLED TRIAL OF GABAPENTIN Barbara Mason, The Scripps Research Institute, La Jolla, CA Boris Taabakoff, Skaggs School of Pharmacy and Pharmaceutical Sciences, Univ. of Colorado, Aurora, CO 11:40am - 12:20pm RSA BUSINESS (MEMBERSHIP) MEETING - open to RSA members GRAND
11:40am - 1:50pm ALCOHOL AND ALCOHOLISM Editorial Board Meeting / Lunch - closed
12:30pm - 1:50pm ACER: ALCOHOLISM: CLINICAL AND EXPERIMENTAL RESEARCH - closed
Board of Field Editors Meeting / Luncheon 12:30pm - 1:50pm NIAAA-SUPPORTED RESEARCH: A GRANTSMANSHIP WORKSHOP - open GRAND
Organized by the RSA Education Committee Chair: Robert Miranda, Jr.
Everyone Welcome - Light Lunch available for those who RSVP'd in advance - ticket required 12:30pm - 1:50pm ANIMAL RESEARCH UNDER ATTACK: WHY YOU SHOULD CARE - open GRAND
Organized by the RSA Animal Research and Ethics Committee Chairs: Jeff Weiner and Christa Helms Everyone Welcome - Light Lunch available for those who RSVP'd in advance - ticket required 12:30pm - 1:50pm LGBT NETWORKING WORKSHOP - open LAUREL
Organized by Paul Gilbert and Amelia Talley Bring your lunch and join us!! ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
TUESDAY,
TUESDAY,
SYMPOSIUM
ALCOHOL USE BEYOND YOUNG ADULTHOOD: PREDICTORS, PATTERNS, AND CONSEQUENCES
Organizers/Chairs: Deborah Capaldi, Oregon Social Learning Center, Eugene, OR
and Helene White, Rutgers Center of Alcohol Studies, Piscataway, NJ
2:00 INTRODUCTION Deborah Capaldi, Oregon Social Learning Center, Eugene, OR PROFILES OF ALCOHOL USE IN EARLY MID-ADULTHOOD AND ASSOCIATION TO USE PATTERNS IN YOUNG ADULTHOOD Deborah Capaldi, Oregon Social Learning Center, Eugene, OR CHILDHOOD & ADOLESCENT PREDICTORS OF ADULT ALCOHOL PROBLEMS: GENERAL & ALCOHOL-SPECIFIC CUMULATIVE RISK FACTORS IN FAMILY, PEER, & SCHOOL CONTEXTS Jungeon Olivia Lee, Social Development Research Group, School of Social Work, Univ. of Washington, Seattle, WA THE ROLE OF ALCOHOL AND DRUGS IN PERSISTENCE OF SERIOUS VIOLENT OFFENDING FROM YOUNG ADULTHOOD TO EARLY MID-ADULTHOOD Helene White, Rutgers Center of Alcohol Studies, Piscataway, NJ ASSOCIATIONS BETWEEN EXPOSURE TO LIFE STRESS AND ALCOHOL USE DISORDER IN A LONGITUDINAL BIRTH COHORT STUDIED TO AGE 30 Joseph Boden, Christchurch Health and Development Study, Univ. of Otago, Christchurch, New Zealand Kenneth Leonard, Research Institute on Addictions, Univ. at Buffalo, Buffalo, NY SYMPOSIUM
PHARMACOKINETICS AND HUMAN ALCOHOL RESPONSES: UNCOVERING DYNAMIC
PROCESSES ASSOCIATED WITH RISK FOR ALCOHOL-RELATED PROBLEMS
Organizers/Chairs: William Corbin, Arizona State Univ., Tempe, AZ
and Caitlin Scott, Arizona State Univ., Tempe, AZ
2:00 INTRODUCTION William Corbin, Arizona State Univ., Tempe, AZ FASTER METABOLISM PREDICTS GREATER SUBJECTIVE STIMULATION Stephen Boyd, Dept. of Psychology, Arizona State Univ., Tempe, AZ DIFFERENCES AMONG BEHAVIORS IN THE TIME NEEDED TO RECOVER FROM IMPAIRMENT FOLLOWING A DOSE OF ALCOHOL: HOW SUCH DIFFERENCES CONTRIBUTE TO RISKY DRINKING. Mark Fillmore, Dept. of Psychology, Univ. of Kentucky, Lexington, KY SUBJECTIVE RESPONSE AND ASSOCIATED CRAVING IN HEAVY DRINKERS AND ALCOHOL DEPENDENTS: A TRANSLATIONAL EXAMINATION OF KOOB'S ALLOSTATIC MODEL IN HUMANS Spencer Bujarski, Dept. of Psychology, Univ. of California, Los Angeles, CA DEMOGRAPHIC CHARACTERISTICS DIFFERENTIALLY PREDICT INACCURATE ALCOHOL EXPECTANCIES ASSOCIATED WITH ALCOHOL-RELATED RISK OR PROTECTION Meghan Morean, Dept. of Psychology, Yale Univ. School of Medicine, New Haven, CT Kim Fromme, Dept. of Psychology, Univ. of Texas, Austin, TX ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
TUESDAY, JUNE 24
TUESDAY, JUNE 24
SYMPOSIUM
WHAT'S NEW IN ANIMAL MODELS OF CHRONIC ETHANOL?
Organizer/Chair: Richard Olsen, Geffen School of Medicine, Univ. of California, Los Angeles, CA
Chair: A. Leslie Morrow, Bowles Center for Alcohol Studies, Univ. of North Carolina, Chapel Hill, NC
2:00 INTRODUCTION Richard Olsen, Geffen School of Medicine, Univ. of California, Los Angeles, CA THE RAT CIE MODEL; GABA AND GLUTAMATE RECEPTOR PLASTICITY IN THE REWARD AND STRESS PATHWAYS Igor Spigelman, Div. of Oral Biology and Medicine, Univ. of California School of Dentistry, Los Angeles, CA ADAPTATIONS IN STRIATAL GLUTAMATE NEUROTRANSMISSION IN RELATION TO ALCOHOL DEPENDENCE AND DRINKING Griffi n, Charleston Alcohol Research Center, Medical Univ. of South Carolina, Charleston, SC 3:00 NEUROADAPTATIONS -THP IMMUNOSTAINING IN RESPONSE TO CHRONIC INTERMITTENT ETHANOL EXPOSURE AND FORCED SWIM STRESS IN C57BL/6J MICE Leslie Morrow, Bowles Center for Alcohol Studies, Univ. of North Carolina School of Medicine, Chapel Hill, NC THE RODENT CIE MODEL: GABA RECEPTOR SUBUNIT SWITCHES CONTRIBUTE TO DEPENDENCE Jing Liang, Geffen School of Medicine, Univ. of California, Los Angeles, CA Leslie Morrow, Bowles Center for Alcohol Studies, Univ. of North Carolina, Chapel Hill, NC ROUNDTABLE
TRANSLATIONAL RESEARCH ON ALCOHOLIC HEPATITIS IN NIAAA SUPPORTED CONSORTIUM
Organizers: H. Joe Wang, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
and Andras Orosz, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
Chair: Svetlana Radaeva, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
2:00 INTRODUCTION Sam Zakhari, Distilled Spirits Council, Washington D.C.
OBESITY AND PATTERNS OF ALCOHOL CONSUMPTION ARE ASSOCIATED WITH DISTINCT LIPIDOMIC READOUTS OF Arun Sanyal, Virginia Commonwealth Univ., Richmond, VA NOVEL THERAPIES IN ALCOHOLIC HEPATITIS - UO1 UMMS CONSORTIUM Gyongyi Szabo, Univ. of Massachusetts Memorial Medical Center, Worcester, MA INTEAM CONSORTIUM: TOWARDS A MOLECULAR CLASSIFICATION OF ALCOHOLIC HEPATITIS Ramon Bataller, Univ. of North Carolina, Chapel Hill, NC A RANDOMIZED, CLINICAL TRIAL TO EVALUATE TWO THERAPIES, MYCOPHENOLATE AND RILONACEPT, IN SUBJECTS WITH BIOPSY-PROVEN ALCOHOLIC HEPATITIS Timothy Morgan, Southern California Institute for Research and Education, Long Beach, CA OPEN DISCUSSION MODERATOR Gary Murray, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
TUESDAY, JUNE 24
TUESDAY, JUNE 24
SYMPOSIUM
BRIEF INTERVENTIONS TO REDUCE AT-RISK ALCOHOL USE
IN WOMEN: OUTCOMES IN RANDOMIZED TRIALS
Organizer/Chair: Tatiana Balachova, Univ. of Oklahoma Health Sciences Center, Oklahoma City, OK
Chair: Margaret Murray, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD
2:00 INTRODUCTION Margaret Murray, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD A BRIEF INTERVENTION TO REDUCE THE RISK FOR AN ALCOHOL-EXPOSED PREGNANCY: OUTCOMES OF A RANDOMIZED CLINICAL TRIAL IN RUSSIA Tatiana Balachova, Dept. of Pediatrics, Univ. of Oklahoma Health Sciences Center, Oklahoma City, OK A PILOT RANDOMIZED TRIAL OF COMPUTER-DELIVERED SBIRT FOR ALCOHOL USE DURING PREGNANCY Steven Ondersma, Dept. of Psychiatry and Behavioral Neurosciences, Wayne State Univ., Detroit, MI TELEPHONE VS. IN-PERSON BRIEF INTERVENTION: RESULTS FROM A CLINICAL TRIAL TO REDUCE ALCOHOL-EXPOSED Georgiana Wilton, Dept. of Family Medicine, Univ. of Wisconsin, Madison, WI PREVENTING ALCOHOL AND TOBACCO-EXPOSED PREGNANCIES IN PRIMARY CARE SETTINGS: RESULTS OF A RANDOMIZED CONTROLLED TRIAL Mary Velasquez, Health Behavior Research and Training Institute, Univ. of Texas, Austin, TX John Saunders, Univ. of Queensland & Univ. of Sydney, Sydney, Australia SYMPOSIUM
***TRAUMATIC BRAIN INJURY AND UNHEALTHY ALCOHOL USE: BASIC SCIENCE, CLINICAL
EPIDEMIOLOGY AND INTERVENTION DEVELOPMENT AND IMPLEMENTATION
Organizer/Chair: Rachel Sayko Adams, Heller School for Social Policy & Mgmt., Brandeis Univ., Waltham, MA
Chair: Douglas Zatzick, Dept. of Psychiatry and Behavioral Sciences, Univ. of Washington, Seattle, WA
2:00 INTRODUCTION Rachel Sayko Adams, Inst. for Behavioral Health, Heller School for Social Policy & Mgmt., Brandeis Univ., Waltham, MA EFFECTS OF EXPERIMENTAL TRAUMATIC BRAIN INJURY ON ETHANOL CONSUMPTION, SENSITIVITY AND SYNAPTIC PLASTICITY Alana Conti, Dept. of Neurosurgery, Wayne State Univ. School of Medicine, Detroit, MI TRAUMATIC BRAIN INJURY AND POSTDEPLOYMENT UNHEALTHY DRINKING AMONG ARMY ACTIVE DUTY SERVICE MEMBERS RETURNING FROM OEF/OIF Rachel Sayko Adams, Inst. for Behavioral Health, Heller School for Social Policy & Mgmt., Brandeis Univ., Waltham, MA IN-SESSION THERAPIST AND CLIENT BEHAVIORS IN BRIEF MOTIVATIONAL INTERVENTIONS WITH EMERGENCY DEPARTMENT PATIENTS WITH HEAD TRAUMA Brian Borsari, Center for Alcohol and Addiction Studies, Warren Alpert Medical School of Brown Univ., Providence, RI TRAUMATIC BRAIN INJURY AS A MODERATOR OF ALCOHOL SCREENING AND BRIEF INTERVENTION TREATMENT EFFECTS: RESULTS FROM A MULTISITE PRAGMATIC RANDOMIZED CLINICAL TRIAL Douglas Zatzick, Dept. of Psychiatry and Behavioral Sciences, Univ. of Washington, Seattle, WA Dennis Donovan, Alcohol & Drug Abuse Institute, Univ. of Washington, Seattle, WA ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
TUESDAY, JUNE 24
TUESDAY, JUNE 24
SYMPOSIUM
***TRANSLATIONAL STUDIES ON THE ENDOGENOUS OPIOID SYSTEM IN ALCOHOL DEPENDENCE
Organizer/Chair: Anita Hansson, Inst. Psychopharmacology, Central Inst. Of Mental Health, Mannheim, Germany
Chair: Rainer Spanagel, Dept. of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
2:00 INTRODUCTION Anita Hansson, Inst. Psychopharmacology, Central Inst. Of Mental Health, Mannheim, Germany IMPACT OF KAPPA-OPIOID / DYNORPHIN SYSTEMS AT SPECIFIC STAGES IN ADDICTION TRAJECTORY: TOWARD Eduardo Butelman, Laboratory of the Biology of Addictive Diseases, The Rockefeller Univ., New York, NY BRAIN AREA-SPECIFIC DYSREGULATION OF THE DYNORPHIN / KAPPA-OPIOID RECEPTOR SYSTEM IN HUMAN ALCOHOLICS: IMPLICATIONS FOR PATHOGENESIS. Georgy Bakalkin, Dept. of Pharmaceutical Biosciences, Uppsala Univ., Uppsala, Sweden RSA MEMORIAL AWARDEE - A HUMANIZED MOUSE MODEL OF THE MU-OPIOID RECEPTOR (OPRM1) GENE A118G POLYMORPHISM: DEMONSTRATION OF ALTERED ALCOHOL AND OPIOID RESPONSES Elliott Robinson, Lab. of Developmental Neuropharmacology, Univ. of North Carolina School of Medicine, Chapel Hill, NC TRANSLATIONAL STUDIES ON MU-OPIOID RECEPTOR IN ALCOHOL DEPENDENCE Anita Hansson, Inst. Psychopharmacology, Central Inst. of Mental Health, Mannheim, Germany Rainer Spanagel, Dept. of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany SYMPOSIUM
***IS NEBODY THERE? TRANSLATIONAL ADVANCES IN THE STUDY OF
NOREPINEPHRINE AND THE PATHOPHYSIOLOGY OF ALCOHOLISM
Organizer/Chair: Jeff Weiner, Wake Forest School of Medicine, Winston-Salem, NC
2:00 INTRODUCTION Jeff Weiner, Dept. of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC THE ROLE OF ADRENERGIC AGENTS FOR ALCOHOL AND COCAINE DEPENDENCE Helen Fox, Yale Univ. School of Medicine, The Connecticut Mental Health Center, New Haven, CT MANIPULATING ETHANOL-MOTIVATED BEHAVIORS WITH NORADRENERGIC AGENTS IN RATS SELECTIVELY BRED FOR Cristine Czachowski, Dept. of Psychology, IUPUI, Indianapolis, IN NORADRENERGIC CONTROL OF ETHANOL SENSITIVE CORTICOTROPIN RELEASING FACTOR SIGNALING IN THE BED NUCLEUS OF THE STRIA TERMINALIS Yuval Silberman, Molecular Physiology and Biophysics, Vanderbilt Univ., Nashville, TN 3-ADRENOCEPTORS IN THE BASOLATERAL AMYGDALA REGULATE FEAR LEARNING AND APPETITIVE ETHANOL DRINKING BEHAVIORS Jeff Weiner, Dept. of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC Thomas Kash, Bowles Center for Alcohol Studies, Univ. of North Carolina, Chapel Hill, NC ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
TUESDAY, JUNE 24
TUESDAY, JUNE 24
POSTER SESSION III
POSTER NUMBERS: 1-293 / ABSTRACT NUMBERS: 584-876
two 1-hour manning periods - Number 1 fi rst hour; number 2 second hour, fi nal 30 minutes unmanned period (light refreshments) INTERNATIONAL PERSPECTIVES ON ETIOLOGY AND PREVENTION
OF YOUNG ADULT ALCOHOL AND OTHER SUBSTANCE USE
Organizers/Chairs: Mary Larimer, Univ. of Washington, Seattle, WA
and Mats Berglund, Malmo Univ., Malmo, Sweden
6:30 INTRODUCTION Mary Larimer, Univ. of Washington, Seattle, WA SOCIO-ECONOMIC STATUS AND SUBSTANCE USE AMONG YOUNG MEN Eleni Charitonidi, Alcohol Treatment Center, Lausanne Univ. Hospital, Lausanne, Switzerland PERCEIVED RISK FOR CANNABIS, TOBACCO, AND ALCOHOL: COMPARISON OF US AND SWEDISH HIGH SCHOOL Mats Berglund, Dept. of Health and Welfare, Malmö University, Sweden DRINKING TRAJECTORIES IN US AND SWEDEN YOUNG ADULTS: PATTERNS AND PREDICTORS Katie Witkiewitz, Univ. of New Mexico, Albuquerque, NM ALCOHOL ASSESSMENT & FEEDBACK BY E-MAIL FOR UNIVERSITY STUDENTS: THE AMADEUS TRIALS Jim McCambridge, Faculty of Public Health and Policy, London, England Rob Turrisi, Pennsylvania State, Univ., University Park, PA WORKSHOP
***THE COGNITIVE NEUROSCIENCE OF HABIT: A WINDOW ON ALCOHOL MISUSE
Organizer/Chair: Philip Corlett, Dept. of Psychiatry, Yale Univ., New Haven, CT
6:30 INTRODUCTION Philip Corlett, Dept. of Psychiatry, Yale Univ., New Haven, CT DEPENDENCE-INDUCED ALTERATIONS IN CORTICOSTRIATAL CIRCUITS MEDIATING HABIT FORMATION Jacqui Barker, Center for Drug and Alcohol Programs, Medical Univ. of South Carolina, Charleston, SC ETHANOL INDUCED HABIT FORMATION IN MICE AND MONKEYS: ROLE OF STRIATAL GABAERGIC TRANSMISSION David Lovinger, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD ROLE OF STRESS AND STRESS HORMONES ACROSS DEVELOPMENT IN THE FORMATION OF ALCOHOL SEEKING HABITS Mary Torregrossa, Dept. of Psychiatry, Univ. of Pittsburgh, Pittsburgh, PA Philip Corlett, Dept. of Psychiatry, Yale Univ., New Haven, CT ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
TUESDAY, JUNE 24
TUESDAY, JUNE 24
***PPARS: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS
OR POTENTIAL PROMOTERS OF ALCOHOLISM REDUCTION?
Organizer/Chair: Therese Kosten, Univ. of Houston, Houston, TX
Chair: R. Adron Harris, Waggoner Center for Alcohol and Addiction Research, Univ. of Texas, Austin, TX
6:30 INTRODUCTION Laura Ferguson, Institute for Neuroscience, Univ. of Texas, Austin, TX ROLE OF PPARS IN REGULATION OF BEHAVIORAL EFFECTS OF ETHANOL Yuri Blednov, Waggoner Center for Alcohol and Addiction Research, Univ. of Texas, Austin, TX ARE PPARALPHA AGONISTS POTENTIAL TREATMENT AGENTS FOR ALCOHOLISM AND OTHER ADDICTIONS? Therese Kosten, Univ. of Houston, Houston, TX ACTIVATION OF PPARGAMMA AS A TREATMENT TARGET FOR ALCOHOLISM Roberto Ciccocioppo, Univ. of Camerino, Camerino, Italy PPARS AND THEIR ROLE IN ALCOHOL-RELATED PHENOTYPES IN THE COGA STUDY Tatiana Foroud, Indiana Univ. School of Medicine, Indianapolis, IN R. Adron Harris, Waggoner Center for Alcohol and Addiction Research, Univ. of Texas, Austin, TX ROUNDTABLE
***TRANSLATIONAL RESEARCH ON ALCOHOLIC HEPATITIS IN NIAAA SUPPORTED
CONSORTIUM SESSION II: BENCH-TO-BEDSIDE RESEARCH UPDATE
Organizers: Svetlana Radaeva, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
Gary Murray, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
and Andras Orosz, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
Chair: H. Joe Wang, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
6:30 INTRODUCTION Svetlana Radaeva, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD CASPASE ACTIVATION AS A TARGET FOR ALCOHOL INDUCED HEPATIC INFLAMMATION Vijay Shah, Gastroenterology Research Unit, Dept. of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN HEPATIC PROGENITOR CELL AS A TARGET TO TREAT ALCOHOLIC HEPATITIS Gemma Odena, Univ. of North Carolina, Chapel Hill, NC PATHOGENIC ROLE OF PDE4 IN THE DEVELOPMENT OF ALCOHOLIC LIVER INJURY Leila Gobejishvili, Dept. of Medicine, Univ. of Louisville Medical Center, Louisville, KY HEPATOCYTE-DERIVED DANGER SIGNALS ARE THERAPUETIC TARGETS IN ALCOHOLIC LIVER DISEASE Arvin Iracheta-Vellve, Univ. of Massachusetts Medical School, Worcester, MA PROFILING THE IMMUNE SYSTEM IN THE PATIENTS WITH SEVERE ALCOHOLIC HEPATITIS Zhang-Xu Liu, Research Center for Liver Diseases, Keck School of Medicine, Univ. of Southern California, Los Angeles, CA CHRONIC ETHANOL INGESTION INDUCES KIDNEY OXIDATIVE INJURY THROUGH TAURINE-INHIBITABLE INFLAMMATION C. Latchoumycandane, Cleveland Clinic, Lerner College of Medicine, Cleveland, OH OPEN DISCUSSION MODERATOR Bin Gao, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
WEDNESDAY, JUNE 25
WEDNESDAY, JUNE 25
CONTINENTAL BREAKFAST - Nametag Required
RSA/ISBRA REGISTRATION DESK - Open
PLENARY SESSION IV
JAMES B. ISAACSON AWARDEE (2014)
GENETICS OF ALCOHOL DEPENDENCE: ADVANCING FROM CANDIDATE GENES TO GENOMEWIDE APPROACHES
Joel Gelernter, M.D., Professor of Psychiatry, Genetics and Neurobiology, Yale University School of Medicine, VAMC, West Haven CT Dr. Joel Gelernter is Professor of Psychiatry, Genetics, and Neurobiology at the Yale University School of Medicine; and has a psychiatry ap-pointment at the VA CT Healthcare Center. His research is focused on two related subjects: complex trait genetics – especially concerning ad-diction and anxiety disorders - and basic population genetics, particularly as it relates to gene mapping for complex traits. His work in alcohol dependence genetics has spanned the transition from the candidate gene era to linkage mapping to genomewide association and sequencing studies. Recent publications include GWAS studies for alcohol, cocaine, and opioid dependence, each of which identifi ed novel risk alleles.
Although understudied compared to major psychiatric traits such as schizophrenia and bipolar affective disorder, alcohol dependence genetics has been a productive – and sometimes controversial - research area for decades. And while the former traits have required large sample sizes for unequivocal gene mapping progress, some of the earliest candidate gene fi ndings in alcohol dependence, especially those involving alcohol metabolizing enzyme gene variants, have held up well. This refl ects several basic distinctive facts about alcohol dependence, including its nature as a pharmacogenetic trait, and the existence of risk loci that have large effects (for complex traits) in some populations. Linkage followed by fi ne mapping yielded additional replicable risk variants. Going beyond these in the GWAS era is proving to be diffi cult. In this lecture Dr Gelern-ter will discuss these issues, including approaches to identify novel risk alleles and pathways relevant to alcohol dependence and related traits.
PLENARY SESSION V
RSA YOUNG INVESTIGATOR AWARDEE (2013)
MODULATION OF EMOTIONAL NEURONAL CIRCUITS: IMPLICATIONS FOR ALCOHOL ABUSE
Thomas Kash, Ph.D., Bowles Center for Alcohol Studies at the University of North Carolina at Chapel Hill, Chapel Hill, NC Dr. Thomas Kash earned his BS in Chemistry at the State University of New York College of Environmental Science and Forestryin 1999. Following this, Dr. Kash worked briefl y at the medical department at Brookhaven National Labs under the guidance of Dr. Andrew Gifford before joining Dr. Neil Harrison's lab at Cornell University Graduate College of Biomedical Science in New York City. While a student in Dr. Harrison's lab Dr. Kash worked on understanding the structure and function of ligand-gated ion channels, in particular GABA-A receptors. In 2004, Dr. Kash moved to Dr. Danny Winder's lab at Vanderbilt University in Nashville, TN and began working on understanding how alcohol and peptides can modulate function in the extended amygdala. In 2009, Dr. Kash started his lab at the Bowles Center for Alcohol Studies at the University of North Carolina at Chapel Hill where he has continued his efforts to understand how modulation of neuronal circuits can alter behavior.
Research in my lab has focused on understanding how stress and alcohol abuse can alter neuronal function in brain regions that regulate emo-tional behavior. This is performed using a multidisciplinary approach, ranging from behavioral analysis to detailed mechanistic signaling analysis. The major drive in my work has been to understand how modulation of neuronal circuits can ameliorate pathological behavior associated with neuropsychiatric conditions.
COFFEE BREAK
***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
WEDNESDAY, JUNE 25
WEDNESDAY, JUNE 25
9:30am - 11:30am SYMPOSIUM
WEB-BASED INTERVENTIONS FOR HAZARDOUS AND HARMFUL DRINKING IN THE
INTERNATIONAL CONTEXT: FEASIBILITY UTILITY AND ASSESSMENT OF EFFECTIVENESS
Organizer: Roseli Boerngen de Lacerda, Univ. Federal do Parana, Curitiba, Brazil
Chair: Maria L.O. Souza Formigoni, Univ. Federal de Sao Paulo, Sao Paulo, Brazil
9:30 INTRODUCTION Roseli Boerngen-Lacerda, Univ. Federal do Parana, Curitiba, Brazil WEB-BASED INTERVENTIONS FOR HAZARDOUS AND HARMFUL DRINKING IN THE INTERNATIONAL CONTEXT Dag Rekve, World Health Organization Dept. of Mental Health and Substance Abuse, Geneva, Switzerland BACKGROUND AND OVERVIEW OF A WEB PORTAL ON HARMFUL / HAZARDOUS DRINKING Atul Ambekar, National Drug Dependence Treatment Center, New Delhi, India ADAPTATION OF E-MENTAL HEALTH RESOURCES TO ADDRESS ALCOHOL ABUSE IN MEXICO Marcela Tiburcio, Instituto Nacional de Psiquiatria Ramon de la Fuenta, Mexico D.F., Mexico THE BRAZILIAN PORTAL INFORMALCOOL /BEBERMENOS: AN ONLINE TOOL TO DISSEMINATE INFORMATION AND PROVIDE BRIEF INTERVENTION FOR ALCOHOL RISK USERS Maria L.O. Souza Formigoni, Univ. Federal de Sao Paulo, Sao Paulo, Brazil Maria L.O. Souza Formigoni, Univ. Federal de Sao Paulo, Sao Paulo, Brazil 9:30am - 11:30am SYMPOSIUM
DISPLAYS OF ALCOHOL-RELATED CONTENT ON SOCIAL NETWORKING SITES:
INFLUENCE, INFODEMIOLOGY, AND INTERVENTION OPPORTUNITIES
Organizer: Jennifer Whitehill, Dept. of Public Health, Univ. of Massachusetts, Amherst, MA
Chair: Megan Moreno, Seattle Children's Research Institute, Seattle, WA
9:30 INTRODUCTION Megan Moreno, Center for Child Health Behavior and Development, Seattle Children's Research Institute, Seattle, WA SOCIAL NORMS AND SOCIAL NETWORKING SITES: THE ROLE OF FACEBOOK IN PREDICTING ALCOHOL USE AMONG FIRST-YEAR UNDERGRADUATE STUDENTS Allison Grant, Dept. of Psychology, Colorado State Univ., Fort Collins, CO PEER INFLUENCE ON UNDERGRADUATES' INTENTION TO GET DRUNK BY COMMUNICATION FORMATS Alina Arseniev-Koehler, Dept. of Sociology, Univ. of Washington, Seattle, WA PATTERNS IN DRUNK-DRIVING REFERENCES ON TWITTER: A CONTENT ANALYSIS Jennifer Whitehill, Dept. of Public Health, Univ. of Massachusetts, Amherst, MA COLLEGE STUDENTS' DISPLAY OF FACEBOOK ALCOHOL REFERENCES AND DIGITAL COMMUNICATION TO PARENTS Bradley Kerr, Center for Child Health Behavior and Development, Seattle Children's Research Institute, Seattle, WA Robert Freeman, Div. of Epidemiology and Prevention Research, NIAAA, Bethesda, MD ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
WEDNESDAY, JUNE 25
WEDNESDAY, JUNE 25
9:30am - 11:30am SYMPOSIUM
BEHAVIORAL MANIPULATION AND ALCOHOL MISUSE
Organizer/Chair: Peter Dodd, Univ. of Queensland, Brisbane, Australia
Organizer: Andrew Lawrence, The Florey Institute of Neuroscience, Melbourne, Australia
Chair: Anthony Hannan, The Florey Institute of Neuroscience, Melbourne, Australia
9:30 INTRODUCTION Anthony Hannan, The Florey Institute of Neuroscience, Melbourne, Australia BEHAVIORAL INTERVENTIONS TO AMELIORATE THE OUTCOMES OF FASD: LESSONS FROM ANIMAL MODEL Anna Klintsova, Univ. of Delaware, Newark, DE ENVIRONMENTAL ENRICHMENT ATTENUATES BEHAVIOURAL AND NEUROCHEMICAL EFFECTS OF ETHANOL: A MODEL OF EUSTRESS Rosana Camarini, Univ. de Sao Paulo, Sao Paulo, Brazil ENVIRONMENTAL MODIFICATION DURING ABSTINENCE PREVENTS MANIFESTATION OF DEPRESSIVE PHENOTYPE IN A MOUSE MODEL OF CHRONIC ALCOHOL CONSUMPTION Terence Pang, The Florey Institute of Neuroscience, Melbourne, Australia ENVIRONMENTAL STRESSORS, DYNORPHIN, AND CRF IN ALCOHOL-SEEKING AND REINSTATEMENT Anh Dzung Le, Dept. of Pharmacology and Toxicology, Univ. of Toronto, Toronto, Canada Anthony Hannan, The Florey Institute of Neuroscience, Melbourne, Australia 9:30am - 11:30am SYMPOSIUM
INDIVIDUAL DIFFERENCES IN ALCOHOLISM? A MULTIDISCIPLINARY APPROACH
Organizer/Chair: Heidi Lesscher, Dept. of Animals in Science and Society, Utrecht Univ., Utrecht, The Netherlands
9:30 INTRODUCTION Heidi Lesscher, Dept. of Animals in Science & Society, Div. of Beh. Neuroscience, Utrecht Univ., Utrecht, The Netherlands INTRAPERSONAL REWARD-RELATED FACTORS IN THE LONGITUDINAL PREDICTION OF ADOLESCENT SUBSTANCE USE Tim Janssen, Univ. of Amsterdam, Amsterdam, The Netherlands BEHAVIORAL AND MOLECULAR CHARACTERISTICS OF MICE ‘AT-RISK' FOR BINGE-LIKE DRINKING Amanda Barkley-Levenson, Portland Alcohol Research Center, Oregon Health and Science Univ., Portland, OR INDIVIDUAL VULNERABILITY TO ALCOHOL INTAKE IN RELATION TO DECISION MAKING AND PAVLOVIAN APPROACH Marcia Spoelder, Dept. of Animals in Sci. & Society, Div. of Beh. Neuroscience, Utrecht Univ., Utrecht, The Netherlands HIGH TRAUMATIC STRESS REACTIVITY ESCALATES ALCOHOL DRINKING AND RECRUITS CRF IN PREFRONTAL-AMYGDALA CIRCUITRY Nicholas Gilpin, Dept. of Physiology, Louisiana State Univ. Health Science Center, New Orleans, LA John Crabbe, Portland Alcohol Research Center, Oregon Health and Science Univ., Portland, OR ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
WEDNESDAY, JUNE 25
WEDNESDAY, JUNE 25
9:30am - 11:30am SYMPOSIUM
***EARLY LIFE STRESS AND ALCOHOL: TRANSLATIONAL APPROACHES TO
EXAMINATION OF RISK FACTORS AND BEHAVIORAL AND BIOLOGICAL OUTCOMES
Organizer/Chair: Vijay Ramchandani, Section on Human Psychopharmacology, NIAAA, Bethesda, MD
Chair: Mary-Anne Enoch, Laboratory of Neurogenetics, NIAAA, Rockville, MD
9:30 INTRODUCTION Mary-Anne Enoch, Laboratory of Neurogenetics, NIAAA, Rockville, MD EARLY LIFE STRESS AND TRAUMA: PREVALENCE IN ALCOHOL DEPENDENT AND NON-DEPENDENT DRINKERS, AND ASSOCIATIONS WITH ALCOHOL-RELATED PHENOTYPES Melanie Schwandt, Laboratory of Clinical and Translational Studies, NIAAA, Bethesda, MD EARLY LIFE STRESS, ALCOHOL DEPENDENCE, AND POST-TRAUMATIC STRESS DISORDER: EVIDENCE FOR DISRUPTIONS IN PHYSIOLOGIC OUTCOMES Laura Kwako, Laboratory of Clinical and Translational Studies, NIAAA, Bethesda, MD EARLY LIFE STRESS CAUSES LONG TERM EFFECTS ON NEUROPEPTIDES, ALCOHOL CONSUMPTION AND BEHAVIOUR: RESULTS FROM A TRANSLATIONAL INITIATIVE Ingrid Nylander, Dept. of Pharmaceutical Biosciences, Uppsala Univ., Uppsala, Sweden LIFETIME ADVERSITY HAS A DISPROPORTIONATE IMPACT IN PERSONS WITH A FAMILY HISTORY OF ALCOHOLISM: THE OKLAHOMA FAMILY HEALTH PATTERNS PROJECT William Lovallo, Dept. of Psychiatry, Oklahoma Univ. Health Sciences Center and VA Medical Center, Oklahoma City, OK Michael De Bellis, Dept. of Psychiatry and Behavioral Sciences, Duke Univ. School of Medicine, Durham, NC 9:30am - 11:30am SYMPOSIUM
***TRANSLATIONAL NEUROIMAGING IN ALCOHOLISM: NEURAL EFFECTS OF ABSTINENCE AND NALTREXONE
Organizer/Chair: Wolfgang Sommer, Central Institute of Mental Health, Univ. of Heidelberg, Mannheim, Germany
Chair: Natalie Zahr, Stanford Univ. School of Medicine, Stanford, CA
9:30 INTRODUCTION Wolfgang Sommer, Central Institute of Mental Health, Univ. of Heidelberg, Mannheim, Germany MANGANESE-ENHANCED MRI REVEALS GENETICALLY DETERMINED BRAIN NETWORKS UNDERLYING HIGH ALCOHOL CONSUMPTION AND NALTREXONE RESPONSE IN RATS Petri Hyytia, Institute of Biomedicine and Pharmacology, Univ. of Helsinki, Helsinki, Finland ALTERED MRI RESPONSES DURING PROTRACTED ABSTINENCE AS A PREDICTOR FOR RELAPSE BEHAVIOUR IN ALCOHOL DEPENDENT PATIENTS AND RATS Wolfgang Sommer, Central Institute of Mental Health, Univ. of Heidelberg, Mannheim, Germany IN VIVO DIFFUSION TENSOR IMAGING EVIDENCE FOR REVERSIBLE WHITE MATTER MICROSTRUCTURAL INTEGRITY DISRUPTION: EFFECTS OF ABSTINENCE IN RAT AND MAN Natalie Zahr, Stanford Univ. School of Medicine, Stanford, CA RELATIONSHIPS BETWEEN MR BRAIN IMAGING CONNECTIVITY MEASURES AND RECOVERY FROM ALCOHOL DEPENDENCE Matthew Brown, Dept. of Psychiatry, Univ. of Alberta, Edmonton, Canada Friedbert Weiss, Dept. of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
WEDNESDAY, JUNE 25
WEDNESDAY, JUNE 25
9:30am - 11:30am SYMPOSIUM
CIFASD STUDIES OF GENETIC SUSCEPTIBILITY TO FETAL ALCOHOL SPECTRUM DISORDERS
Organizer/Chair: Michael Charness, Harvard Medical Sch., Boston Univ. Sch. of Medicine, West Roxbury, MA
9:30 INTRODUCTION Michael Charness, Harvard Medical Sch., Boston Univ. Sch. of Medicine & VA Boston Healthcare System, West Roxbury, MA USING GENETIC SCREENS IN ZEBRAFISH TO IDENTIFY ETHANOL-SENSITIVE LOCI Johann Eberhart, Molecular Biosciences, Univ. of Texas, Austin, TX IDENTIFICATION OF CANDIDATE FASD SUSCEPTIBILITY GENES IN L1 TRANSFECTED FIBROBLASTS AND MOUSE EMBRYOS Xiaowei Dou, Harvard Medical School, West Roxbury, MA ANALYSING GENETIC AND TERATOGENIC EFFECTS OF ALCOHOL ON FACIAL FORM Peter Hammond, Univ. College London, Institute of Child Health, London, England GENE X PRENATAL ALCOHOL EXPOSURE: PRELIMINARY RESULTS IN SRC FAMILY KINASE AND PDGF PATHWAYS Leah Wetherill, Indiana Univ. School of Medicine, Indianapolis, IN Michael Charness, Harvard Medical Sch., Boston Univ. Sch. of Medicine & VA Boston Healthcare System, West Roxbury, MA 9:30am - 11:30am SYMPOSIUM
REDUCING UNSAFE DRINKING AND OTHER RISK BEHAVIORS IN THOSE WITH HIV:
BEHAVIORAL, PHARAMACOLOGIC AND TECHNOLOGY-ENHANCED APPROACHES
Organizers/Chairs: Deborah Hasin, Columbia Univ. and New York State Psychiatric Institute, New York, NY
and Kendall Bryant, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD
9:30 INTRODUCTION Deborah Hasin, Columbia Univ. and New York State Psychiatric Institute, New York, NY ALCOHOL AND HIV MEDICATION ADHERENCE: TAKING AN INTERVENTION FROM EFFICACY TO EFFECTIVENESS Jeffrey Parsons, Hunter College and the Graduate Center of the City Univ. of New York, New York, NY ADAPTING MOTIVATIONAL INTERVIEWING TO ADDRESS HEAVY DRINKING WITHIN THE CONTEXT OF HIV CLINICAL CARE AMONG MEN WHO HAVE SEX WITH MEN Christopher Kahler, Center for Alcohol and Addiction Studies, Brown Univ. School of Public Health, Providence, RI HEALTHCALL: TECHNOLOGY-BASED EXTENSION OF BRIEF INTERVENTION FOR HEAVY DRINKING OR DRUG USE IN HIV PRIMARY CARE PATIENTS Deborah Hasin, Columbia Univ. and New York State Psychiatric Institute, New York, NY TRIALS OF INTEGRATED STEPPED CARE AND INJECTABLE NALTREXONE FOR UNHEALTHY ALCOHOL USE IN HIV-INFECTED PATIENTS David Fiellin, Yale Univ. School of Medicine, New Haven, CT Kendall Bryant, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 11:45am - 1:15pm SPECIAL SESSION
WORKSHOP: RESEARCH AND CLINICAL COMMUNITIES WORKING TOGETHER: AN INTERNATIONAL PERSPECTIVE
Organized by: RSA and NCADD Bring your lunch and join us!!!
***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
RSA/ISBRA 2014 DAILY SCHEDULE
WEDNESDAY, JUNE 25
WEDNESDAY, JUNE 25
11:45am - 12:45pm SPECIAL SESSION
"The John and Patricia O'Neill Addiction Science Education Award"
Organized by Carlton Erickson on behalf of the Texas Research Society on Alcoholism
CHARACTERISTICS OF FAMILY MEMBERS WHO RECEIVE OVERDOSE EDUCATION IN THE COMMUNITY
SPEAKER: Sarah Bagley, M.D., Boston Medical Center, Boston, MA 11:45am - 12:45pm RSA 2015 PROGRAM COMMITTEE MEETING - closed
11:45am - 12:45pm RSA EDUCATION COMMITTEE MEETING - closed
11:45am - 12:40pm ISBRA GENERAL ASSEMBLY BUSINESS MEETING - open to ISBRA members
12:40pm - 1:15pm SPECIAL LECTURE: HIROMASA ISHII MEMORIAL AWARD (2014)
Dr. Yedy Israel presented by Dr. Yoshinorie Horie POSTER SESSION IV
POSTER NUMBERS: 1-292 / ABSTRACT NUMBERS: 877-1168
two 1-hour manning periods - Number 1 fi rst hour; number 2 second hour, fi nal 30 minutes unmanned period (light refreshments) COGA STEERING COMMITTEE - closed
7:00pm - Midnight 2014 RSA/ISBRA CLOSING CEREMONY AND AWARDS PRESENTATIONS
Dinner/Presentations: 7:00pm followed by Dancing ISBRA President's Junior Investigator Awards - to be announced 2014-2018 ISBRA Board of Directors Announcement ISBRA International Service Recognition Award - DR. KENNETH WARREN 2014 James B. Isaacson Award - DR. JOEL GELERNTER Hiromasa Ishii Memorial Award - DR. YEDY ISRAEL ISBRA President Acknowledgement - DR. EDWARD RILEY RSA Young Investigator Award - DRS. JAMES MACKILLOP and LARA RAY RSA Distinguished Researcher Award - DR. CINDY EHLERS RSA Henri Begleiter Excellence in Research Award - DR. GEORGE FEIN RSA Lifetime Achievement Award - DR. KENNETH WARREN RSA Marlatt Mentorship Award - DR. SANDRA BROWN RSA Seixas Award - to be announced RSA Media Award - MS. ANN DOWSETT JOHNSTON Enoch Gordis Awardees - to be announced 2014 RSA New Offi cers Announcement RSA / ISBRA MEETING ADJOURNED
RSA: "Funding for this conference was made possible (in part) by 2R13AA18227-03 from the National Institute on Alcohol Abuse and Alcoholism. The views expressed in written conference materials or publications and by speakers and moderators do not neces-sarily refl ect the offi cial policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government." ISBRA: "Funding for this Congress was made possible (in part) by grant 1 R13 AA022578-01 from the National Institute on Alcohol Abuse and Alcoholism. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily refl ect the offi cial policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government." ***Indicates a translational symposium. We strongly encouraged proposals that bridge different types of research (e.g., preclinical and clinical), to provide the opportunity for society members with different interests to interact.
Source: http://www.rsoa.org/2014meet-2-RSA-ISBRA-DAILY-SCHEDULE.pdf
specsavers.co.uk
Optical training 12082_Healthcall_Training Doc_MASTER.indd 1-2 Promoting eye health and maximising independence for all Code of Practice for Domiciliary Eyecare September 2009 The Domiciliary Eyecare Committee is grateful for the comments of the UK Departments of Health on this Code • NHS eye examinations will be provided on request to those who cannot access
Pervasive spine
Fakultät Technik und InformatikStudiendepartment Informatik Hamburg, den 28.Februar 2008 1. Einleitung und Motivation 2.2. Pervasive Gaming Computing . . . . . . . . . . . . . 3. Projekt 3.2. Aufgabenverteilung . . . . . . . . . . . . . . . . 3.4.1. PS Community Manager . . . . . . . . . . . . 3.4.2. PS Orientierungseinheit 3.5.1. Fachliche Anforderungen . . . . . . . . . . . .