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Thinner #12
Hazard Alert Code: HIGH
Altex Coatings Limited GHS Safety Data Sheet (REVIEW)
Issue Date: 31-May-2012
ALTEX COATINGS LIMITED 9-36064
Version No:1
Page 1 of 12
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
Thinner #12
PROPER SHIPPING NAME
9-36064
PAINT RELATED MATERIAL
PRODUCT USE
■ Used according to manufacturer's directions.
Thinner
Company: Altex Coatings Ltd ALTEX COATINGS LIMITED 91-111 Oropi Road, Tauranga, New Zealand, 3112 - +64 7 5411221, Fax +64 7 5411310 91- 111 Oropi Road, Tauranga, NEW ZEALAND RESENE PAINTS (AUSTRALIA) LIMITED; T/A ALTEX COATINGS 7 Production Avenue, Molendinar, QLD 4214, Australia - +61 7 32870222, Fax +61 7 32870226 Telephone: +64 7 5411974Fax: +64 7 5411310 Section 2 - HAZARDS IDENTIFICATION
GHS Classification
Acute Toxicity Category 5
Eye Irritation Category 2A
Flammable Liquid Category 2
Reproductive Toxicity Category 2
Skin Corrosion/Irritation Category 2
STOT - SE Category 3
Determined by Chemwatch using GHS criteriaH225 Highly flammable liquid and vapour.
May be harmful if swallowed Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Suspected of damaging fertility or the unborn child.
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Keep container tightly closed.
Ground/bond container and receiving equipment.
Thinner #12
Hazard Alert Code: HIGH
Altex Coatings Limited GHS Safety Data Sheet (REVIEW)
Issue Date: 31-May-2012
ALTEX COATINGS LIMITED 9-36064
Version No:1
Page 2 of 12
Section 2 - HAZARDS IDENTIFICATION
Use explosion- proof electrical/ventilating/lighting/ . /equipment Use only non- sparking tools.
Take precautionary measures against static discharge.
Wash . thoroughly after handling.
Use only outdoors or in a well- ventilated area.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
IF ON SKIN (or hair): Remove/Take off immediately all contaminatedclothing. Rinse skin with water/shower.
IF INHALED: Remove victim to fresh air and keep at rest in a positioncomfortable for breathing.
IF IN EYES: Rinse cautiously with water for several minutes. Removecontact lenses, if present and easy to do. Continue rinsing.
IF exposed or concerned: Get medical advice/attention.
Call a POISON CENTER or doctor/physician if you feel unwell.
If eye irritation persists: Get medical advice/attention.
Store in a well- ventilated place. Keep container tightly closed.
Store in a well- ventilated place. Keep cool.
Store locked up.
Dispose of contents/container to .
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
methyl isobutyl ketone Section 4 - FIRST AID MEASURES
SWALLOWED
• If swallowed do NOT induce vomiting.
• If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain open airway and
prevent aspiration.
• Observe the patient carefully.
• Never give liquid to a person showing signs of being sleepy or with reduced awareness; i.e. becoming unconscious.
• Avoid giving milk or oils.
• Avoid giving alcohol.
• If spontaneous vomiting appears imminent or occurs, hold patient's head down, lower than their hips to help avoid possible
aspiration of vomitus.
EYE
■ If this product comes in contact with the eyes:
• Wash out immediately with fresh running water.
• Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting
the upper and lower lids.
• Seek medical attention without delay; if pain persists or recurs seek medical attention.
• Removal of contact lenses after an eye injury should only be undertaken by skilled personnel.
SKIN
■ If skin contact occurs:
• Immediately remove all contaminated clothing, including footwear.
• Flush skin and hair with running water (and soap if available).
Thinner #12
Hazard Alert Code: HIGH
Altex Coatings Limited GHS Safety Data Sheet (REVIEW)
Issue Date: 31-May-2012
ALTEX COATINGS LIMITED 9-36064
Version No:1
Page 3 of 12
Section 4 - FIRST AID MEASURES
• Seek medical attention in event of irritation.
INHALED
• If fumes or combustion products are inhaled remove from contaminated area.
• Lay patient down. Keep warm and rested.
• Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating first aid
procedures.
• Apply artificial respiration if not breathing, preferably with a demand valve resuscitator, bag-valve mask device, or pocket
mask as trained. Perform CPR if necessary.
NOTES TO PHYSICIAN
■ Any material aspirated during vomiting may produce lung injury. Therefore emesis should not be induced mechanically or
pharmacologically.
for simple ketones:
--------------------------------------------------------------
BASIC TREATMENT
--------------------------------------------------------------
• Establish a patent airway with suction where necessary.
• Watch for signs of respiratory insufficiency and assist ventilation as necessary.
• Administer oxygen by non-rebreather mask at 10 to 15 l/min.
• Monitor and treat, where necessary, for pulmonary oedema .
For acute or short term repeated exposures to isopropanol:
• Rapid onset respiratory depression and hypotension indicates serious ingestions that require careful cardiac and respiratory
monitoring together with immediate intravenous access.
• Rapid absorption precludes the usefulness of emesis or lavage 2 hours post-ingestion. Activated charcoal and cathartics are not clinically useful. Ipecac is most useful when given 30 mins. post-ingestion.
• There are no antidotes.
• Management is supportive. Treat hypotension with fluids followed by vasopressors.
For acute or short term repeated exposures to xylene:• Gastro-intestinal absorption is significant with ingestions. For ingestions exceeding 1-2 ml (xylene)/kg, intubation and lavage with cuffed endotracheal tube is recommended. The use of charcoal and cathartics is equivocal.
• Pulmonary absorption is rapid with about 60-65% retained at rest.
• Primary threat to life from ingestion and/or inhalation, is respiratory failure.
• Patients should be quickly evaluated for signs of respiratory distress (e.g. cyanosis, tachypnoea, intercostal retraction, obtundation) and given oxygen. Patients with inadequate tidal volumes or poor arterial blood gases (pO2 < 50 mm Hg or pCO2 > 50mm Hg) should be intubated.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
• Alcohol stable foam.
• Dry chemical powder.
• BCF (where regulations permit).
• Carbon dioxide.
FIRE FIGHTING
• Alert Fire Brigade and tell them location and nature of hazard.
• May be violently or explosively reactive.
• Wear breathing apparatus plus protective gloves in the event of a fire.
• Prevent, by any means available, spillage from entering drains or water course.
When any large container (including road and rail tankers) is involved in a fire,
consider evacuation by 500 metres in all directions.
FIRE/EXPLOSION HAZARD
• Liquid and vapour are highly flammable.
• Severe fire hazard when exposed to heat, flame and/or oxidisers.
• Vapour may travel a considerable distance to source of ignition.
• Heating may cause expansion or decomposition leading to violent rupture of containers.
Combustion products include: carbon dioxide (CO2), formaldehyde, other pyrolysis products typical of burning organic material.
WARNING: Long standing in contact with air and light may result in the formation
of potentially explosive peroxides.
Thinner #12
Hazard Alert Code: HIGH
Altex Coatings Limited GHS Safety Data Sheet (REVIEW)
Issue Date: 31-May-2012
ALTEX COATINGS LIMITED 9-36064
Version No:1
Page 4 of 12
Section 5 - FIRE FIGHTING MEASURES
FIRE INCOMPATIBILITY
• Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as ignition may
Section 6 - ACCIDENTAL RELEASE MEASURES
MINOR SPILLS
• Remove all ignition sources.
• Clean up all spills immediately.
• Avoid breathing vapours and contact with skin and eyes.
• Control personal contact with the substance, by using protective equipment.
MAJOR SPILLS
■ Chemical Class: ketones
For release onto land: recommended sorbents listed in order of priority.
.
• Clear area of personnel and move upwind.
• Alert Fire Brigade and tell them location and nature of hazard.
• May be violently or explosively reactive.
• Wear breathing apparatus plus protective gloves.
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
• Containers, even those that have been emptied, may contain explosive vapours.
• Do NOT cut, drill, grind, weld or perform similar operations on or near containers.
• DO NOT allow clothing wet with material to stay in contact with skin.
• Electrostatic discharge may be generated during pumping - this may result in fire.
• Ensure electrical continuity by bonding and grounding (earthing) all equipment.
• Restrict line velocity during pumping in order to avoid generation of electrostatic discharge (<=1 m/sec until fill pipe
submerged to twice its diameter, then <= 7 m/sec).
• Avoid splash filling.
The substance accumulates peroxides which may become hazardous only if it evaporates or is distilled or otherwise treated to
concentrate the peroxides. The substance may concentrate around the container opening for example.
Purchases of peroxidisable chemicals should be restricted to ensure that the chemical is used completely before it can become
peroxidised.
• A responsible person should maintain an inventory of peroxidisable chemicals or annotate the general chemical inventory to
indicate which chemicals are subject to peroxidation. An expiration date should be determined. The chemical should either be
treated to remove peroxides or disposed of before this date.
• Avoid all personal contact, including inhalation.
• Wear protective clothing when risk of exposure occurs.
• Use in a well-ventilated area.
• Prevent concentration in hollows and sumps.
SUITABLE CONTAINER
• Packing as supplied by manufacturer.
• Plastic containers may only be used if approved for flammable liquid.
• Check that containers are clearly labelled and free from leaks.
• For low viscosity materials (i) : Drums and jerry cans must be of the non-removable head type. (ii) : Where a can is to be used
as an inner package, the can must have a screwed enclosure.
• For materials with a viscosity of at least 2680 cSt. (23 deg. C)
• For manufactured product having a viscosity of at least 250 cSt. (23 deg. C)
• Manufactured product that requires stirring before use and having a viscosity of at least 20 cSt (25 deg. C).
Thinner #12
Hazard Alert Code: HIGH
Altex Coatings Limited GHS Safety Data Sheet (REVIEW)
Issue Date: 31-May-2012
ALTEX COATINGS LIMITED 9-36064
Version No:1
Page 5 of 12
Section 7 - HANDLING AND STORAGE
• may ignite or explode in contact with strong oxidisers, 1,3-dichloro-5,5-dimethylhydantoin, uranium fluoride• attack some plastics, rubber and coatings• may generate electrostatic charges on flow or agitation due to low conductivity.
Isopropanol (syn: isopropyl alcohol, IPA):• forms ketones and unstable peroxides on contact with air or oxygen; the presence of ketones especially methyl ethyl ketone (MEK, 2-butanone) will accelerate the rate of peroxidation• reacts violently with strong oxidisers, powdered aluminium (exothermic), crotonaldehyde, diethyl aluminium bromide (ignition), dioxygenyl tetrafluoroborate (ignition/ ambient temperature), chromium trioxide (ignition), potassium-tert-butoxide (ignition), nitroform (possible explosion), oleum (pressure increased in closed container), cobalt chloride, aluminium triisopropoxide, hydrogen plus palladium dust (ignition), oxygen gas, phosgene, phosgene plus iron salts (possible explosion), sodium dichromate plus sulfuric acid (exothermic/ incandescence), triisobutyl aluminium• reacts with phosphorus trichloride forming hydrogen chloride gas• reacts, possibly violently, with alkaline earth and alkali metals, strong acids, strong caustics, acid anhydrides, halogens, aliphatic amines, aluminium isopropoxide, isocyanates, acetaldehyde, barium perchlorate (forms highly explosive perchloric ester compound), benzoyl peroxide, chromic acid, dialkylzincs, dichlorine oxide, ethylene oxide (possible explosion), hexamethylene diisocyanate (possible explosion), hydrogen peroxide (forms explosive compound), hypochlorous acid, isopropyl chlorocarbonate, lithium aluminium hydride, lithium tetrahydroaluminate, nitric acid, nitrogen dioxide, nitrogen tetraoxide (possible explosion), pentafluoroguanidine, perchloric acid (especially hot), permonosulfuric acid, phosphorus pentasulfide, tangerine oil, triethylaluminium, triisobutylaluminium, trinitromethane.
Methyl isobutyl ketone (MIBK)• forms unstable and explosive peroxides on contact with air and/ or when in contact with hydrogen peroxide• reacts violently with strong oxidisers, aldehydes, aliphatic amines, nitric acid, perchloric acid, potassium tert-butoxide, strong acids, reducing agents• dissolves some plastics, resins and rubber.
• Vigorous reactions, sometimes amounting to explosions, can result from the contact between aromatic rings and strong oxidising agents.
• Aromatics can react exothermically with bases and with diazo compounds.
Alcohols• are incompatible with strong acids, acid chlorides, acid anhydrides, oxidising and reducing agents.
• reacts, possibly violently, with alkaline metals and alkaline earth metals to produce hydrogen• react with strong acids, strong caustics, aliphatic amines, isocyanates, acetaldehyde, benzoyl peroxide, chromic acid, chromium oxide, dialkylzincs, dichlorine oxide, ethylene oxide, hypochlorous acid, isopropyl chlorocarbonate, lithium tetrahydroaluminate, nitrogen dioxide, pentafluoroguanidine, phosphorus halides, phosphorus pentasulfide, tangerine oil, triethylaluminium, triisobutylaluminium• should not be heated above 49 deg. C. when in contact with aluminium equipment.
Ketones in this group:• are reactive with many acids and bases liberating heat and flammable gases (e.g., H2).
• react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat.
• are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides.
• react violently with aldehydes, HNO3 (nitric acid), HNO3 + H2O2 (mixture of nitric acid and hydrogen peroxide), and HClO4 (perchloric acid).
Secondary alcohols and some branched primary alcohols may produce potentially explosive peroxides after exposure to light and/ or heat.
STORAGE REQUIREMENTS
• Store in original containers in approved flame-proof area.
• No smoking, naked lights, heat or ignition sources.
• DO NOT store in pits, depressions, basements or areas where vapours may be trapped.
• Keep containers securely sealed.
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
The following materials had no OELs on our records
• xylene:
• methyl isobutyl ketone: Thinner #12
Hazard Alert Code: HIGH
Altex Coatings Limited GHS Safety Data Sheet (REVIEW)
Issue Date: 31-May-2012
ALTEX COATINGS LIMITED 9-36064
Version No:1
Page 6 of 12
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
IDLH Level: 900 ppmOdour Threshold Value: 20 ppm (detection), 40 ppm (recognition)NOTE: Detector tubes for o-xylene, measuring in excess of 10 ppm, are available commercially. (m-xylene and p-xylene give almost the same response).<</>.
METHYL ISOBUTYL KETONE:THINNER #12: ■ for methyl isobutyl ketone (MIBK):Unfatigued, odour recognition threshold (100% test panel) is 0.3 - 0.5 ppm.
Distinct odour at 15 ppm.
Odour is objectionable and vapours are irritating to eyes at 200 ppm.
NOTE: Detector tubes for methyl isobutyl ketone, measuring in excess of 50 ppm, are commercially available.
ISOPROPANOL:THINNER #12: ■ Odour Threshold Value: 3.3 ppm (detection), 7.6 ppm (recognition)Exposure at or below the recommended isopropanol TLV-TWA and STEL is thought to minimise the potential for inducing narcotic effects or significant irritation of the eyes or upper respiratory tract. It is believed, in the absence of hard evidence, thatthis limit also provides protection against the development of chronic health effects.
■ Exposure limits with "skin" notation indicate that vapour and liquid may be absorbed through intact skin. Absorption by skin may readily exceed vapour inhalation exposure.
METHYL ISOBUTYL KETONE: ■ Exposed individuals are reasonably expected to be warned, by smell, that the Exposure Standard is being exceeded.
Odour Safety Factor (OSF) is determined to fall into either Class A or B.
The Odour Safety Factor (OSF) is defined as:OSF= Exposure Standard (TWA) ppm/ Odour Threshold Value (OTV) ppmClassification into classes follows: Over 90% of exposed individualsare aware by smell that theExposure Standard (TLV- TWA forexample) is being reached, evenwhen distracted by workingactivities As " A" for 50- 90% of personsbeing distracted As " A" for less than 50% ofpersons being distracted 10- 50% of persons aware ofbeing tested perceive by smellthat the Exposure Standard isbeing reached As " D" for less than 10% ofpersons aware of being tested RESPIRATOR
•Type A Filter of sufficient capacity. (AS/NZS 1716 & 1715, EN 143:2000 & 149:2001, ANSI Z88 or national equivalent)
EYE
• Safety glasses with side shields.
• Chemical goggles.
• Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy document,
describing the wearing of lens or restrictions on use, should be created for each workplace or task. This should include areview of lens absorption and adsorption for the class of chemicals in use and an account of injury experience. Medical andfirst-aid personnel should be trained in their removal and suitable equipment should be readily available. In the event ofchemical exposure, begin eye irrigation immediately and remove contact lens as soon as practicable. Lens should be removed atthe first signs of eye redness or irritation - lens should be removed in a clean environment only after workers have washedhands thoroughly. [CDC NIOSH Current Intelligence Bulletin 59], [AS/NZS 1336 or national equivalent].
Thinner #12
Hazard Alert Code: HIGH
Altex Coatings Limited GHS Safety Data Sheet (REVIEW)
Issue Date: 31-May-2012
ALTEX COATINGS LIMITED 9-36064
Version No:1
Page 7 of 12
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
HANDS/FEET
• Wear chemical protective gloves, eg. PVC.
• Wear safety footwear or safety gumboots, eg. Rubber.
Suitability and durability of glove type is dependent on usage. Important factors in the selection of gloves include:
• frequency and duration of contact,
• chemical resistance of glove material,
• glove thickness and
• dexterity.
OTHER
• Overalls.
• PVC Apron.
• PVC protective suit may be required if exposure severe.
• Eyewash unit.
• Some plastic personal protective equipment (PPE) (e.g. gloves, aprons, overshoes) are not recommended as they may produce
static electricity.
For large scale or continuous use wear tight-weave non-static clothing (no metallic fasteners, cuffs or pockets), non sparking safety footwear.
ENGINEERING CONTROLS
■ CARE: Use of a quantity of this material in confined space or poorly ventilated area, where rapid build up of concentrated
atmosphere may occur, could require increased ventilation and/or protective gear.
Engineering controls are used to remove a hazard or place a barrier between the worker and the hazard. Well-designed engineering
controls can be highly effective in protecting workers and will typically be independent of worker interactions to provide this
high level of protection.
The basic types of engineering controls are:
Process controls which involve changing the way a job activity or process is done to reduce the risk.
Enclosure and/or isolation of emission source which keeps a selected hazard "physically" away from the worker and ventilation
that strategically "adds" and "removes" air in the work environment.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Clear Colour with Characteristic Odour
PHYSICAL PROPERTIES
Liquid.
Does not mix with water.
Floats on water.
Melting Range (°C) Boiling Range (°C) Solubility in water (g/L) Flash Point (°C) Decomposition Temp (°C) Autoignition Temp (°C) Vapour Pressure (kPa) Upper Explosive Limit (%) Specific Gravity (water=1) Lower Explosive Limit (%) Relative Vapour Density Volatile Component (%vol) Thinner #12
Hazard Alert Code: HIGH
Altex Coatings Limited GHS Safety Data Sheet (REVIEW)
Issue Date: 31-May-2012
ALTEX COATINGS LIMITED 9-36064
Version No:1
Page 8 of 12
Section 10 - CHEMICAL STABILITY
CONDITIONS CONTRIBUTING TO INSTABILITY
• Presence of incompatible materials.
• Product is considered stable.
• Hazardous polymerisation will not occur.
For incompatible materials - refer to Section 7 - Handling and Storage.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
■ Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be
fatal or may produce serious damage to the health of the individual.
■ Swallowing of the liquid may cause aspiration of vomit into the lungs with the risk of haemorrhaging, pulmonary oedema,
progressing to chemical pneumonitis; serious consequences may result.
Signs and symptoms of chemical (aspiration) pneumonitis may include coughing, gasping, choking, burning of the mouth, difficult
breathing, and bluish coloured skin (cyanosis).
■ Following ingestion, a single exposure to isopropyl alcohol produced lethargy and non-specific effects such as weight loss and
irritation. Ingestion of near-lethal doses of isopropanol produces histopathological changes of the stomach, lungs and kidneys,
incoordination, lethargy, gastrointestinal tract irritation, and inactivity or anaesthesia.<</>.
■ Considered an unlikely route of entry in commercial/industrial environments The liquid may produce considerable
gastrointestinal discomfort and may be harmful or toxic if swallowed. Ingestion may result in nausea, pain and vomiting.
■ Effects on the nervous system characterise over-exposure to higher aliphatic alcohols. These include headache, muscle weakness,
giddiness, ataxia, (loss of muscle coordination), confusion, delirium and coma.
EYE
■ Evidence exists, or practical experience predicts, that the material may cause severe eye irritation in a substantial number of
individuals and/or may produce significant ocular lesions which are present twenty-four hours or more after instillation into the
eye(s) of experimental animals. Eye contact may cause significant inflammation with pain.
■ At concentrations of 100-200 ppm MIBK, the vapour may irritate the eyes and respiratory tract.
■ Isopropanol vapour may cause mild eye irritation at 400 ppm. Splashes may cause severe eye irritation, possible corneal burns
and eye damage.
■ The liquid produces a high level of eye discomfort and is capable of causing pain and severe conjunctivitis. Corneal injury may
develop, with possible permanent impairment of vision, if not promptly and adequately treated.
SKIN
■ The material produces moderate skin irritation; evidence exists, or practical experience predicts, that the material either
•
produces moderate inflammation of the skin in a substantial number of individuals following direct contact, and/or • produces significant, but moderate, inflammation when applied to the healthy intact skin of animals (for up to four hours), such inflammation being present twenty-four hours or more after the end of the exposure period. <</>.
■ Most liquid alcohols appear to act as primary skin irritants in humans. Significant percutaneous absorption occurs in rabbitsbut not apparently in man.
■ Open cuts, abraded or irritated skin should not be exposed to this material.
■ Toxic effects may result from skin absorption.
■ Entry into the blood-stream through, for example, cuts, abrasions, puncture wounds or lesions, may produce systemic injury withharmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
INHALED
■ Evidence shows, or practical experience predicts, that the material produces irritation of the respiratory system, in a
substantial number of individuals, following inhalation. In contrast to most organs, the lung is able to respond to a chemical
insult by first removing or neutralising the irritant and then repairing the damage.
■ Exposure to aliphatic alcohols with more than 3 carbons may produce central nervous system effects such as headache, dizziness,
drowsiness, muscle weakness, delirium, CNS depression, coma, seizure, and neurobehavioural changes. Symptoms are more acute with
higher alcohols.
■ Inhalation hazard is increased at higher temperatures.
■ Acute effects from inhalation of high concentrations of vapour are pulmonary irritation, including coughing, with nausea;
central nervous system depression - characterised by headache and dizziness, increased reaction time, fatigue and loss of co-
ordination.
■ Human overexposure to MIBK vapour may produce weakness, loss of appetite, headache, a burning sensation to the eyes, stomach-
Thinner #12
Hazard Alert Code: HIGH
Altex Coatings Limited GHS Safety Data Sheet (REVIEW)
Issue Date: 31-May-2012
ALTEX COATINGS LIMITED 9-36064
Version No:1
Page 9 of 12
Section 11 - TOXICOLOGICAL INFORMATION
ache, nausea and vomiting. Sore throat, insomnia, somnolence, heartburn and intestinal pain have been reported by some workers.
Exposure to high concentrations (>1000 ppm) can produce central nervous system depression and narcosis.
■ Headache, fatigue, lassitude, irritability and gastrointestinal disturbances (e.g., nausea, anorexia and flatulence) are themost common symptoms of xylene overexposure. Injury to the heart, liver, kidneys and nervous system has also been noted amongstworkers.
■ The odour of isopropanol may give some warning of exposure, but odour fatigue may occur. Inhalation of isopropanol may produceirritation of the nose and throat with sneezing, sore throat and runny nose.
■ Xylene is a central nervous system depressant. Central nervous system (CNS) depression may include nonspecific discomfort,symptoms of giddiness, headache, dizziness, nausea, anaesthetic effects, slowed reaction time, slurred speech and may progress tounconsciousness.
■ Exposure to ketone vapours may produce nose, throat and mucous membrane irritation. High concentrations of vapour may producecentral nervous system depression characterised by headache, vertigo, loss of coordination, narcosis and cardiorespiratoryfailure.
CHRONIC HEALTH EFFECTS
■ Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related
systemic problems.
Exposure to the material may cause concerns for human fertility, generally on the basis that results in animal studies provide
sufficient evidence to cause a strong suspicion of impaired fertility in the absence of toxic effects, or evidence of impaired
fertility occurring at around the same dose levels as other toxic effects, but which are not a secondary non-specific consequence
of other toxic effects.
On the basis, primarily, of animal experiments, concern has been expressed by at least one classification body that the material
may produce carcinogenic or mutagenic effects; in respect of the available information, however, there presently exists
inadequate data for making a satisfactory assessment.
Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs
or biochemical systems.
Experiments with rats exposed to MIBK have shown nerve changes characteristic of neuropathy (disease of the peripheral nerves
usually causing weakness and numbness).
Chronic occupational exposure to 500 ppm MIBK in air (20-30 mins/day, and 80 ppm for the remainder of the workday resulted in
nausea, headache, burning eyes, and weakness in over half the workers.
Prolonged or repeated contact with xylenes may cause defatting dermatitis with drying and cracking. Chronic inhalation of xylenes
has been associated with central nervous system effects, loss of appetite, nausea, ringing in the ears, irritability, thirst
anaemia, mucosal bleeding, enlarged liver and hyperplasia.
Long term or repeated ingestion exposure of isopropanol may produce incoordination, lethargy and reduced weight gain.
Repeated inhalation exposure to isopropanol may produce narcosis, incoordination and liver degeneration.
Chronic solvent inhalation exposures may result in nervous system impairment and liver and blood changes. [PATTYS].
TOXICITY AND IRRITATION
OTHER
■ Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may be due to a non-
allergenic condition known as reactive airways dysfunction syndrome (RADS) which can occur following exposure to high levels of
highly irritating compound.
The material may produce severe irritation to the eye causing pronounced inflammation. Repeated or prolonged exposure to
irritants may produce conjunctivitis.
The material may cause skin irritation after prolonged or repeated exposure and may produce a contact dermatitis (nonallergic).
This form of dermatitis is often characterised by skin redness (erythema) and swelling the epidermis.
For methyl isobutyl ketone (MIBK):
MIBK is primarily absorbed by the lungs in animals and humans; it can however be absorbed by the gastrointestinal system and
through skin.
In two cases involving individuals exposed to the vapour MIBK was found in the brain, liver, lung, vitreous fluid, kidney and
blood.<</>.
International Agency for Research on Cancer (IARC) -Agents Reviewed by the IARCMonographs International Agency for Research on Cancer (IARC) -Agents Reviewed by the IARCMonographs Thinner #12
Hazard Alert Code: HIGH
Altex Coatings Limited GHS Safety Data Sheet (REVIEW)
Issue Date: 31-May-2012
ALTEX COATINGS LIMITED 9-36064
Version No:1
Page 10 of 12
Section 11 - TOXICOLOGICAL INFORMATION
Isopropyl alcohol International Agency for Research on Cancer (IARC) -Agents Reviewed by the IARCMonographs Isopropyl alcohol International Agency for manufacture using Research on Cancer (IARC) - Agents Reviewed by the IARCMonographs ILO Chemicals in the electronics industry Reduced fertility or that have toxic effects on reproduction Section 12 - ECOLOGICAL INFORMATION
This material and its container must be disposed of as hazardous waste.
methyl isobutyl ketone Section 13 - DISPOSAL CONSIDERATIONS
• Containers may still present a chemical hazard/ danger when empty.
• Return to supplier for reuse/ recycling if possible.
Otherwise:• If container can not be cleaned sufficiently well to ensure that residuals do not remain or if the container cannot be used to store the same product, then puncture containers, to prevent re-use, and bury at an authorised landfill.
• Where possible retain label warnings and MSDS and observe all notices pertaining to the product.
Legislation addressing waste disposal requirements may differ by country, state and/ or territory. Each user must refer to laws operating in their area.
A Hierarchy of Controls seems to be common - the user should investigate:• Reduction.
• DO NOT allow wash water from cleaning or process equipment to enter drains.
• It may be necessary to collect all wash water for treatment before disposal.
• In all cases disposal to sewer may be subject to local laws and regulations and these should be considered first.
• Where in doubt contact the responsible authority.
• Recycle wherever possible.
• Consult manufacturer for recycling options or consult local or regional waste management authority for disposal if no suitable treatment or disposal facility can be identified.
• Dispose of by: burial in a land-fill specifically licenced to accept chemical and / or pharmaceutical wastes or Incineration in a licenced apparatus (after admixture with suitable combustible material).
• Decontaminate empty containers. Observe all label safeguards until containers are cleaned and destroyed.
Section 14 - TRANSPORTATION INFORMATION
Labels Required: FLAMMABLE LIQUID Thinner #12
Hazard Alert Code: HIGH
Altex Coatings Limited GHS Safety Data Sheet (REVIEW)
Issue Date: 31-May-2012
ALTEX COATINGS LIMITED 9-36064
Version No:1
Page 11 of 12
Section 14 - TRANSPORTATION INFORMATION
Land Transport UNDG:Class or division: UN packing group: Shipping Name:PAINT RELATED MATERIAL (including paint thinning or reducing compound) Air Transport IATA:
ICAO/IATA Class:
ICAO/IATA Subrisk: Special provisions: Cargo OnlyPacking Instructions: Maximum Qty/Pack: Passenger and Cargo Passenger and Cargo Packing Instructions: Maximum Qty/Pack: Passenger and Cargo Limited Quantity Passenger and Cargo Limited Quantity Packing Instructions: Maximum Qty/Pack: Shipping name:PAINT RELATED MATERIAL Maritime Transport IMDG:
IMDG Class:
Special provisions: Limited Quantities: Shipping name:PAINT RELATED MATERIAL Section 15 - REGULATORY INFORMATION
Thinner #12 (CAS: ) is found on the following regulatory lists;
"GESAMP/EHS Composite List - GESAMP Hazard Profiles", "IMO IBC Code Chapter 17: Summary of minimum requirements", "IMO MARPOL
73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk", "IMO Provisional Categorization of Liquid Substances -
List 3: (Trade-named) mixtures containing at least 99% by weight of components already assessed by IMO, presenting safety
hazards", "International Agency for Research on Cancer (IARC) - Agents Reviewed by the IARC Monographs", "International Fragrance
Association (IFRA) Survey: Transparency List", "OECD List of High Production Volume (HPV) Chemicals", "WHO Guidelines for
Drinking-water Quality - Guideline values for chemicals that are of health significance in drinking-water"
Regulations for ingredients
xylene (CAS: 1330-20-7) is found on the following regulatory lists;
"GESAMP/EHS Composite List - GESAMP Hazard Profiles", "IMO IBC Code Chapter 17: Summary of minimum requirements", "IMO MARPOL
73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk", "IMO Provisional Categorization of Liquid Substances -
List 3: (Trade-named) mixtures containing at least 99% by weight of components already assessed by IMO, presenting safety
hazards", "International Agency for Research on Cancer (IARC) - Agents Reviewed by the IARC Monographs", "International Council
of Chemical Associations (ICCA) - High Production Volume List", "International Fragrance Association (IFRA) Survey: Transparency
List", "OECD List of High Production Volume (HPV) Chemicals", "OSPAR List of Chemicals for Priority Action", "WHO Guidelines for
Drinking-water Quality - Guideline values for chemicals that are of health significance in drinking-water"
methyl isobutyl ketone (CAS: 108-10-1) is found on the following regulatory lists;
"GESAMP/EHS Composite List - GESAMP Hazard Profiles", "IMO IBC Code Chapter 17: Summary of minimum requirements", "IMO MARPOL
73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk", "International Agency for Research on Cancer (IARC) -
Agents Reviewed by the IARC Monographs", "International Fragrance Association (IFRA) Survey: Transparency List", "OECD List of
High Production Volume (HPV) Chemicals", "OSPAR National List of Candidates for Substitution – Norway"
isopropanol (CAS: 67-63-0) is found on the following regulatory lists;
"GESAMP/EHS Composite List - GESAMP Hazard Profiles", "IMO IBC Code Chapter 17: Summary of minimum requirements", "IMO IBC Code
Chapter 18: List of products to which the Code does not apply", "IMO MARPOL 73/78 (Annex II) - List of Other Liquid Substances",
"IMO Provisional Categorization of Liquid Substances - List 2: Pollutant only mixtures containing at least 99% by weight of
Thinner #12
Hazard Alert Code: HIGH
Altex Coatings Limited GHS Safety Data Sheet (REVIEW)
Issue Date: 31-May-2012
ALTEX COATINGS LIMITED 9-36064
Version No:1
Page 12 of 12
Section 15 - REGULATORY INFORMATION
components already assessed by IMO", "International Agency for Research on Cancer (IARC) - Agents Reviewed by the IARC Monographs", "International Fragrance Association (IFRA) Survey: Transparency List", "OECD List of High Production Volume (HPV) Chemicals", "OSPAR National List of Candidates for Substitution – Norway" Section 16 - OTHER INFORMATION
■ Classification of the preparation and its individual components has drawn on official and authoritative sources using available literature references.
■ The (M)SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards are Risks in the workplace or other settings.
Issue Date: 31-May-2012Print Date: 31-May-2012

Source: http://www.multigard.com.au/wp-content/uploads/2015/12/Thinner-12-AU-SDS-1705.pdf

Prac recommendations on signals adopted at the prac meeting of 8-11 september 2014

25 September 2014 EMA/PRAC/490498/2014 Pharmacovigilance Risk Assessment Committee PRAC recommendations on signals Adopted at the PRAC meeting of 8-11 September 2014 This document provides an overview of the recommendations adopted by the Pharmacovigilance Risk Assessment Committee (PRAC) on the signals discussed during the meeting of 8-11 September 2014 (including the signal European Pharmacovigilance Issues Tracking Tool [EPITT]reference numbers).

06-apsychobiological

A PSYCHOBIOLOGICAL MODEL OF TEMPERAMENT AND CHARACTER: TCI My heart leaps up when I A rainbow in the sky: CLONINGER'IN PSIKOBIYOLOJIK MIZAÇ (HUY) VE KARATER So was it when my life be- So is it now I am a man: So be it when I shall grow Cloninger kiﬂili¤in iki temel bileﬂeni olan mizaç ve karakterdeki normal ve anormal varyas- yonlar› aç›klayan boyutsal bir psikobiyolojik kiﬂilik modeli geliﬂtirmiﬂtir. Cloninger, mizac›n